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Albumin particles for intra-articular delivery of celecoxib to treat osteoarthritic inflammation.

Project description

An albumin-based drug delivery system for osteoarthritis

Treatment of the autoimmune condition osteoarthritis (OA) is mainly symptomatic, with intra-articular (IA) delivery of free corticosteroids and hyaluronic acid being the best available options. However, the rapid clearance of these injected molecules from the joint following IA delivery necessitates multiple injections and renders delivery of these molecules inconvenient and poorly effective. To address this limitation, scientists of the EU-funded IA-NANO project propose to develop albumin particles loaded with the non-steroid anti-inflammatory drug, celecoxib. This long-acting delivery system is biocompatible and biodegradable, and should allow controlled release of the drug in the inflamed joint, thereby reducing the number of injections with free drug and overcoming system toxicity.

Coordinator

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Net EU contribution
€ 196 590,72
Address
Belfield
4 Dublin
Ireland

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Region
Ireland Eastern and Midland Dublin
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00