Project description DEENESFRITPL Memory formation may rely on the brainstem and hippocampus being in sync Structural and functional maps of the brain and brainstem have shed important light on neuronal circuits and their interconnections. When combined with behavioural studies, interconnected activity can be linked to higher functions. While the hippocampus has long been known to play a key role in memory processes, the role of the brainstem in memory remains largely unknown. However, synchronised activity has been linked to memory formation, and the brainstem modulates it during sleep and wakefulness. DREAM is simultaneously recording neuronal activity in the brainstem and hippocampus in mice performing a memory task or asleep mice. Advanced signal processing and machine learning could provide a model of the dynamic interactions between the brainstem and hippocampus and their relation to memory processes. Show the project objective Hide the project objective Objective Storing information and then using it to guide behaviour is one of the most remarkable abilities of the brain. Memory storage relies on network mechanisms in which the hippocampal formation interacts with the rest of the brain during periods of sleep. The neural computations associated with this process correlate with both enduring and transient changes in the excitability of neural circuits. Nuclei located in the brainstem dictate these ‘state changes’, modulating the signalling between groups of forebrain cells. However, the role of the brainstem in memory formation remains unknown. This project aims to determine the role of different sleep stages in memory formation and long-term consolidation, and to elucidate the functional role of the brainstem in these processes. To this end, I will use a battery of experimental techniques, mathematical methods and biophysical models to probe and analyse the neural activity of the brainstem-hippocampal system. Neuronal activity will be recorded concurrently from the pons, thalamus and hippocampus of mice while performing a reference memory task. I will identify specific neural mechanisms that trigger different hippocampal synchrony regimes and memory reactivations mediated by brainstem activity during wakefulness and sleep. For this, I will develop state-of-the-art methods based on signal processing and machine learning. Besides, using optogenetic tools, I will determine the causal role of the brainstem in regulating hippocampal circuits and the animals’ behavioural performance. Finally, I will develop a biophysical model to test how well different network mechanisms explain the dynamics of the interactions between the brainstem and the hippocampus. Understanding the detailed properties of the interactions between these systems of the brain in relation to memory processes will be an important step toward establishing neurophysiological markers that can be preventive targets to ameliorate effects of memory-related pathologies. Fields of science engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsignal processingmedical and health sciencesbasic medicinepathologynatural sciencescomputer and information sciencesartificial intelligencemachine learning Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2018 - Individual Fellowships Call for proposal H2020-MSCA-IF-2018 See other projects for this call Funding Scheme MSCA-IF-EF-ST - Standard EF Coordinator INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA Net EU contribution € 174 167,04 Address Am campus 1 3400 Klosterneuburg Austria See on map Region Ostösterreich Niederösterreich Wiener Umland/Nordteil Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
