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A Single-Molecule Technology for Resolving Chaperone Action in Neurodegenerative Diseases

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Publications

Rapid Structural, Kinetic, and Immunochemical Analysis of Alpha-Synuclein Oligomers in Solution

Author(s): William E. Arter, Catherine K. Xu, Marta Castellana-Cruz, Therese W. Herling, Georg Krainer, Kadi L. Saar, Janet R. Kumita, Christopher M. Dobson, Tuomas P. J. Knowles
Published in: Nano Letters, 20/11, 2020, Page(s) 8163-8169, ISSN 1530-6984
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.0c03260

Microfluidic approaches for the analysis of protein–protein interactions in solution

Author(s): William E. Arter, Aviad Levin, Georg Krainer, Tuomas P. J. Knowles
Published in: Biophysical Reviews, 12/2, 2020, Page(s) 575-585, ISSN 1867-2450
Publisher: Springer Verlag
DOI: 10.1007/s12551-020-00679-4

Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions

Author(s): Georg Krainer, Timothy J. Welsh, Jerelle A. Joseph, Jorge R. Espinosa, Sina Wittmann, Ella de Csilléry, Akshay Sridhar, Zenon Toprakcioglu, Giedre Gudiškytė, Magdalena A. Czekalska, William E. Arter, Jordina Guillén-Boixet, Titus M. Franzmann, Seema Qamar, Peter St George-Hyslop, Anthony A. Hyman, Rosana Collepardo-Guevara, Simon Alberti, Tuomas P. J. Knowles
Published in: Nature Communications, 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-21181-9

Single particle zeta-potential measurements reveal the role of electrostatics in protein condensate stability

Author(s): Welsh, Timothy J.; Krainer, Georg; Espinosa, Jorge R.; Joseph, Jerelle A.; Sridhar, Akshay; Jahnel, Marcus; Arter, William E.; Saar, Kadi L.; Alberti, Simon; Collepardo-Guevara, Rosana; Knowles, Tuomas P.J.
Published in: Biorxiv, 2020
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2020.04.20.047910

The Hsc70 Disaggregation Machinery Removes Monomer Units Directly from α-Synuclein Fibril Ends

Author(s): Matthias M. Schneider, Saurabh Gautam, Therese W. Herling, Ewa Andrzejewska, Georg Krainer, Alyssa M. Miller, Quentin A. E. Peter, Francesco Simone Ruggeri, Michele Vendruscolo, Andreas Bracher, Christopher M. Dobson, F. Ulrich Hartl, Tuomas P. J. Knowles
Published in: Biorxiv, 2020
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2020.11.02.365825