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Dynamic directed functional connectivity of causal learning

Project description

Determining causal learning networks in the brain

Comprehending how we learn causal relations has been an issue dating as far back as antiquity. Even with today’s advances in technology and neuroscience, among other fields, the exact pathway the brain uses to build such beliefs remains elusive. The working hypothesis of the CausalBrain project is that several brain regions are involved through directed interactions in forming networks to help the brain learn. By using magnetoencephalographic data collected during a causal learning task, the project aims to clarify this pathway further, and to test current causal learning theories against behavioral and brain data.

Objective

Humans have an extraordinary capacity to infer cause-effect relations and form beliefs about the causal effect of actions. This ability provides the basis for rational decision-making and allows people to engage in meaningful life and social interactions. In fact, alterations of cognitive processes involved in causal learning have been found in patients affected by psychiatric disorders such as obsessive-compulsive disorder, schizophrenia and addiction. The formation of causal beliefs relies on learning rules determined by the contingency between actions and outcomes. Although fronto-striatal areas are known to be involved in the cogntive architecture of causal beliefs, it is still unknown how these brain regions interact to learn causal structures. This project aims to unravel the link between functional brain networks and causal reasoning. We hypothesize that causal representation are implemented in a dynamic distributed network of directed functional interactions between brain regions and that this network is shaped by learning. We will characterize the modulations of brain circuits involved in learning phases as well as the brain networks responsible of internal representations of contingency values and associated uncertainty. We are going to pursue these two aims by analyzing magneto-encephalografic and intracranial electro-encephalographic data collected during a causal reasoning task. We will use state-of-the-art methods for dynamic directed connectivity estimation. In addition, we will develop machine learning pipelines to found those subnetworks that implement the cognitive architecture of causal learning. Overall, we will be able to understand whether causal learning and the psychological internal variables predicted by rational theories are reflected in dynamically changing directional influences in whole-brain circuits.

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Topic(s)

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Funding Scheme

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MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) H2020-MSCA-IF-2018

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Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 196 707,84
Address
RUE MICHEL ANGE 3
75794 PARIS
France

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Region
Ile-de-France Ile-de-France Paris
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Research Organisations
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 196 707,84
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