Project description
An organ-on-chip model for osteoarthritis
Osteoarthritis (OA) is a degenerative disease of the joints causing significant disability. Existing pharmacological treatments are symptomatic and cannot reverse the pathology. The key objective of the EU-funded uKNEEversal project is to develop an in vitro OA model that can recapitulate the complexity of the disease and can be used to study the OA underlying mechanisms. Researchers will use human organs-on-chips (OOC) that closely and faithfully resemble the function of native organs in a miniaturised and controlled environment. The OOC technology will help generate an in vitro human OA joint model capable of predicting response to specific drugs.
Objective
uKNEEversal aims at generating a comprehensive in vitro human model of Osteoarthritis (OA) to fill lacks of existing pre-clinical tools and open perspectives to investigate OA mechanisms and therapies. Degenerative joint diseases, among which OA is the most prevalent, represent the second cause of disability worldwide. Available pharmacological options are limited and focus on the reduction of symptoms, being unable to factually reverse the pathology. One of the major obstacles towards the development of disease-reversing therapies is the gap of knowledge on OA mechanisms, linked to the lack of reliable OA pre-clinical models. Existing pre-clinical tools are currently not able to dissect OA complexity in terms of cross talks among compartments and molecular pathways affected. Although animal models may offer a complex enough model, they often fail in predicting typical human responses and recent legislation about 3R principle is pushing Pharma towards methods alternative to animals. In this regards, one ground-breaking goal in the field is the generation of an OA model able to reflect the complexity of the disease in vitro. To date, most in vitro OA models, based on traditional 2D and macroscale culture systems, are affected by sampling sites, poor scalability, and are too simplistic to recapitulate joint 3D architecture. As an alternative, human organs-on-chips (OOC) have been claimed able to transform many areas of basic research and drug development. OOC are in vitro tools that can recapitulate a human organ’s function better than traditional culture systems, in a miniaturized environment. Miniaturization has indeed showed an enhanced control leading to in vitro models recapitulating the native organ functions with accuracy hardly achievable at the macroscale.
In this scenario, uKNEEversal aims at filling the gap of existing poorly predictive pre-clinical models generating an in vitro human osteoarthritic joint model through organs-on-chip technology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology
- medical and health sciences clinical medicine rheumatology
- engineering and technology other engineering and technologies microtechnology organ on a chip
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2018
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
20133 Milano
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.