Structural and functional studies of enterovirus 2C proteins: promising targets for antiviral therapy.

Project Information

EV-2C

Grant agreement ID: 842333

DOI

10.3030/842333

Project closed

EC signature date 22 March 2019

Start date 1 April 2019

End date 31 March 2021

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 175 572,48

EU contribution

€ 175 572,48

Coordinated by

UNIVERSITEIT UTRECHT
Netherlands

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Other (2)

Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes the hexameric complex

Author(s): Daniel L. Hurdiss, Priscila El Kazzi, Lisa Bauer, Nicolas Papageorgiou, François P. Ferron, Tim Donselaar, Arno L.W. van Vliet, Bruno Canard, Etienne Decroly, Andrea Brancale, Tzviya Zeev-Ben-Mordehai, Friedrich Förster, Frank J.M van Kuppeveld1, Bruno Coutard
Published in: bioRxiv, 2021
Publisher: Cold Spring Harbor
DOI: 10.1101/2021.04.26.440876

Highly potent anti-SARS-CoV-2 multi-DARPin therapeutic candidates

Author(s): Marcel Walser, Sylvia Rothenberger, Daniel L. Hurdiss, Anja Schlegel, Valérie Calabro, Simon Fontaine, Denis Villemagne, Maria Paladino, Tanja Hospodarsch, Alexandra Neculcea, Andreas Cornelius, Patricia Schildknecht, Mirela Matzner, Martin Hänggi, Marco Franchini, Yvonne Kaufmann, Iris Schlegel, Chloe Iss, Thamar Loser, Susanne Mangold, Christel Herzog, Dieter Schiegg, Christian Reichen, Filip
Published in: bioRxiv, 2020
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2020.08.25.256339

Peer reviewed articles (4)

Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humans

Author(s): Daniel L. Hurdiss, Ieva Drulyte, Yifei Lang, Tatiana M. Shamorkina, Matti F. Pronker, Frank J. M. van Kuppeveld, Joost Snijder, Raoul J. de Groot
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-18440-6

Rational design of highly potent broad-spectrum enterovirus inhibitors targeting the nonstructural protein 2C

Author(s): Lisa Bauer, Roberto Manganaro, Birgit Zonsics, Daniel L. Hurdiss, Marleen Zwaagstra, Tim Donselaar, Naemi G. E. Welter, Regina G. D. M. van Kleef, Moira Lorenzo Lopez, Federica Bevilacqua, Thamidur Raman, Salvatore Ferla, Marcella Bassetto, Johan Neyts, Jeroen R. P. M. Strating, Remco H. S. Westerink, Andrea Brancale, Frank J. M. van Kuppeveld
Published in: PLOS Biology, Issue 18/11, 2020, Page(s) e3000904, ISSN 1545-7885
Publisher: PLOS
DOI: 10.1371/journal.pbio.3000904

Synthesis and antiviral effect of novel fluoxetine analogues as enterovirus 2C inhibitors

Author(s): Roberto Manganaro, Birgit Zonsics, Lisa Bauer, Moira Lorenzo Lopez, Tim Donselaar, Marleen Zwaagstra, Fabiana Saporito, Salvatore Ferla, Jeroen R.P.M. Strating, Bruno Coutard, Daniel L. Hurdiss, Frank J.M. van Kuppeveld, Andrea Brancale
Published in: Antiviral Research, Issue 178, 2020, Page(s) 104781, ISSN 0166-3542
Publisher: Elsevier BV
DOI: 10.1016/j.antiviral.2020.104781

Structural insights into the cross-neutralization of SARS-CoV and SARS-CoV-2 by the human monoclonal antibody 47D11

Author(s): Juliette Fedry, Daniel L. Hurdiss, Chunyan Wang, Wentao Li, Gonzalo Obal, Ieva Drulyte, Wenjuan Du, Stuart C. Howes, Frank J.M. van Kuppeveld, Friedrich Förster, Berend-Jan Bosch
Published in: Science Advances, 2021, Page(s) eabf5632, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.abf5632