Descripción del proyecto DEENESFRITPL Cuidado, hongos: el despliegue rápido de exterminadores está en camino Si bien la mayoría de los hongos no son patógenos vegetales, los pocos que sí lo son provocan daños importantes. Los hongos destruyen anualmente aproximadamente una tercera parte de los cultivos alimentarios del mundo, lo que no solo afecta al suministro de alimentos, sino que también menoscaba las economías y contribuye a la pobreza mundial. El desarrollo de fungicidas hace medio siglo fue esencial para combatir esta amenaza, pero la resistencia a estos y las cepas muy agresivas constituyen un problema cada vez mayor. El proyecto MAHT-FunSST, financiado con fondos europeos, llevará el desarrollo de fungicidas a la era de los laboratorios en un chip gracias a una nueva plataforma microfluídica de cribado de alto rendimiento que ayudará a proteger el suministro mundial de alimentos, que ya lucha por sobrevivir frente al cambio climático. Mostrar el objetivo del proyecto Ocultar el objetivo del proyecto Objetivo Fungicide development and screening is stuck in an innovation gap, in which it incurs staggering expenses and takes many years to get a fungicide to market, furthermore, many pathogens develop resistance against fungicides which necessitates the sensitivity screening and recalled fungicides. The present proposal is conceptualized to bridge the gap for high throughput (HT) screening of fungicides effectively, by designing the novel lab-on-chip device. Specifically, we will assess (i) baseline sensitivity of fungicides against phyto-pathogenic fungi, (ii) response of fungi to different doses of fungicides, (iii) antifungal effects induced on fungal conidia, (iv) specific enzyme inhibition by fungicide. The fungicide screening lab-on-a-chip will address the large and currently unmet need to model fungicide screening device, regarding the spatial and mechanical cues important for conidia. The project will be based on the state-of-the-art technical expertise of ELVESYS in microfluidic chip design and fabrication and will fully integrate the Experienced Researcher’s (ER) strong expertise with agricultural plant pathology, molecular plant-microbe interactions and fungicides design and screening to develop a HT fungicide screening chip. Testing and validation of the product will be by perfusion using a set of candidate fungicides. The development of lab-on-a-chip technology will result in increasing the pre- and in-field HT screening of fungicides for their efficacy, optimal dosing and toxicity. The device will minimize the cost of fungicide development and screening, thus reducing the economic burden in the EU area as well as having large implications on improving the production of food globally. Through this opportunity the ER will be immersed in a richly entrepreneurial environment at ELVESYS and exposed to marketing concepts. Together, these experiences will provide the ER with the optimal environment to become a leader in next generation tools for fungicide screening. Ámbito científico natural sciencesphysical sciencesclassical mechanicsfluid mechanicsmicrofluidicsengineering and technologyother engineering and technologiesmicrotechnologylab on a chipnatural sciencesbiological sciencesmicrobiologymycologymedical and health sciencesbasic medicinepathologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Programa(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Tema(s) MSCA-IF-2018 - Individual Fellowships Convocatoria de propuestas H2020-MSCA-IF-2018 Consulte otros proyectos de esta convocatoria Régimen de financiación MSCA-IF-EF-SE - Society and Enterprise panel Coordinador ELVESYS Aportación neta de la UEn € 196 707,84 Dirección 172 RUE DE CHARONNE B2 2 EME ETAGE 75011 Paris Francia Ver en el mapa Pyme Organización definida por ella misma como pequeña y mediana empresa (pyme) en el momento de la firma del acuerdo de subvención. Sí Región Ile-de-France Ile-de-France Paris Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 196 707,84
