Growth plate cartilage restoration
Growth plate injuries are responsible for growth arrest, formation of a ‘bony bar’ and angular limb deformities in children. New therapeutic methods for preventing bone formation and growth arrest need to integrate cellular grafts, biomaterials, and growth factors to recapitulate the complex zonal organisation of the growth plate. The resting zone of the growth plate represents one endogenous source of cartilage progenitor cells. The EU-funded Grolaries project will classify and detect these cells during postnatal growth and in reaction to trauma. The project aims to understand whether resting zone cells express skeletal stem cells characteristics, are expandable and multipotent, and contribute to the regeneration of the growth plate in a physeal fracture model.
Fields of science
Funding SchemeMSCA-IF-GF - Global Fellowships
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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