Periodic Reporting for period 1 - BioNanoProbes (Bio-Inspired Glycan-NanoProbes as Antimicrobial Pro-Drugs)
Reporting period: 2019-05-01 to 2021-04-30
Owing to the urgent for novel antimicrobials that target specific bacterial populations, objectives of this Marie Sklodowska Curie Action (MSCA) have been to develop of new chemical tools that can be used to label bacteria and/or delivery of antimicrobial drugs. The novelty of this approach lies not only in the synthetic schemes, but also in the approach and their potential biological applications of the proposed bio-inspired glyco-nanoprobes as antimicrobial pro-drugs.
In summary, the proposed work represents an ambitious and wide ranging multi- and interdisciplinary research programme aimed at developing the next generation of antimicrobials to overcome antibiotic resistance.
The final results derived from the implementation of this action could be disseminated at two different levels: 1) via publication in international scientific journals: leading scientific multidisciplinary journals such Science, Nature (including its specific Nature sister journals), or chemistry journals such as ACIE, JACS or Chem. Sci., depending on the novelty of the discovery. In accordance with the principles of H2020, results will be published in open access whenever possible; and 2) the results could also be disseminated to industrial partners. In this context, potential intellectual property arising from BioNanoProbes could be evaluated and managed by the Technology Transfer Unit of University of Bristol. The research results could be disclosed to potentially interested industrial contacts in the context of non-disclosure agreements, and the possibilities for collaboration with additional industrial funding, and for licensing could be explored. This project could significantly streamline the synthesis of new bio-inspired glyco-nanoprobes as diagnostic tools and antimicrobial pro-drugs, and thus, it is likely that important industrial applications will result. The data sets collected during this MSCA will inform and enhance dozens of publications in the coming years.