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Bio-Inspired Glycan-NanoProbes as Antimicrobial Pro-Drugs

Project description

Glycan-based nanoprobes for delivering antibiotics into bacteria

Cell surface carbohydrates play key roles in bacterial adhesion. These interactions exhibit high specificity and weak affinities towards their carbohydrate ligands, compensated by the host presenting the carbohydrate ligands in a multivalent manner or as clusters on the cell or mucosal surface. A disaccharide can act as a carrier on bi-functionalised fluorescent nanoparticles to help the intracellular delivery of other non-internalisable glycan moieties, avoiding the endosomal/lysosomal degradation pathway. Recently developed water-soluble, non-toxic fluorescent carbon-based nanomaterials have shown that they are capable of labelling both gram-negative and gram-positive bacteria. The EU-funded BioNanoProbes project aims to develop a new class of glycan-based nanoprobes for labelling and delivery of antibiotics into bacteria.


Net EU contribution
€ 212 933,76
Beacon House Queens Road
BS8 1QU Bristol
United Kingdom

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South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bristol, City of
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00