Bridging biophysics and cell biology: The role of G protein-coupled receptor conformations in signalling

Project Information

signalling dynamics

Grant agreement ID: 844622

DOI

10.3030/844622

Project closed

EC signature date 12 April 2019

Start date 1 January 2020

End date 31 December 2022

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 271 732,80

EU contribution

€ 271 732,80

Coordinated by

UNITED KINGDOM RESEARCH AND INNOVATION
United Kingdom

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Publications

Peer reviewed articles (4)

Molecular determinants of ligand efficacy and potency in GPCR signaling

Author(s): Franziska M. Heydenreich, Maria Marti-Solano, Manbir Sandhu, Brian K. Kobilka, Michel Bouvier, M. Madan Babu
Published in: Science, 2023, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.adh1859

Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics

Author(s): John Janetzko, Ryoji Kise, Benjamin Barsi-Rhyne, Dirk H. Siepe, Franziska M. Heydenreich, Kouki Kawakami, Matthieu Masureel, Shoji Maeda, K. Christopher Garcia, Mark von Zastro, Asuka Inoue, Brian K. Kobilka
Published in: Cell, 2022, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2022.10.018

The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites

Author(s): Janik B. Hedderich, Margherita Persechino, Katharina Becker, Franziska M. Heydenreich, Torben Gutermuth, Michel Bouvier, Moritz Bünemann, Peter Kolb
Published in: Nature Communications, Issue 13, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-29609-6

Computationally designed GPCR quaternary structures bias signaling pathway activation

Author(s): Justine S. Paradis, Xiang Feng, Brigitte Murat, Robert E. Jefferson, Badr Sokrat, Martyna Szpakowska, Mireille Hogue, Nick D. Bergkamp, Franziska M. Heydenreich, Martine J. Smit, Andy Chevigné, Michel Bouvier & Patrick Barth
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-34382-7