Project description
Gut-on-a-chip for microbiota analysis
The gut microbiota comprise all the microorganisms present in the human intestine, providing nutrients and energy for the host. Evidence from both mouse and human studies, including faecal microbiota transplantation, underscores the role of diverse microbiota in overall health. The key objective of the EU-funded Goc-MM project is to develop an artificial intestine-based assay that can be employed to assess human microbiota composition. Researchers will generate a gut-on-a-chip experimental model of epithelial cells that supports the culture of human microbiota. The system is user friendly and can be implemented in the analysis of human faecal microbiota in transplantation cases.
Objective
Goc-MM consists of minimal functional portion of gut cultured in a microfluidic devices, gut-on-a-chip, that mimics the environment of intestine. The new gut-on-a-chip that we would produce with this project will be advanced from previous model because of the use of non-absorbed materials with a low production cost and easier to industrialize. This study is focused on culturing and studying human gut-microbiota phyla composition from fecal samples of healthy subjects and both obesity and anorexic patients. Gut microbiota provides nutrients and energy for the host through the products of substrate fermentation in Short Chain Fatty Acids. The motivation that leads us to get involved in this project is to provide to scientific community and industries a convenient and standardized methodology of isolation and cultivation of microbiota from human fecal microbiota transplantation. Goc-MM would supply an experimental model that provides epithelial cells and microbiota to be cultured in presence of physiologically relevant flow and peristalsis like mechanical deformations, which promotes formation of epithelial cells of small intestine. Thanks to the clinical approach of Goc-MM, we will evaluate the different characteristic in the obesity on male and female. Targeting microbiota may represent a new perspective to prevent, reverse or treat obesity, anorexia and other metabolic disorders.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules lipids
- engineering and technology other engineering and technologies microtechnology organ on a chip
- medical and health sciences health sciences nutrition obesity
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-SE - Society and Enterprise panel
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2018
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
93100 MONTREUIL
France
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.