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Human gut microbiota on gut-on-a-chip

Project description

Gut-on-a-chip for microbiota analysis

The gut microbiota comprise all the microorganisms present in the human intestine, providing nutrients and energy for the host. Evidence from both mouse and human studies, including faecal microbiota transplantation, underscores the role of diverse microbiota in overall health. The key objective of the EU-funded Goc-MM project is to develop an artificial intestine-based assay that can be employed to assess human microbiota composition. Researchers will generate a gut-on-a-chip experimental model of epithelial cells that supports the culture of human microbiota. The system is user friendly and can be implemented in the analysis of human faecal microbiota in transplantation cases.


Goc-MM consists of minimal functional portion of gut cultured in a microfluidic devices, gut-on-a-chip, that mimics the environment of intestine. The new gut-on-a-chip that we would produce with this project will be advanced from previous model because of the use of non-absorbed materials with a low production cost and easier to industrialize. This study is focused on culturing and studying human gut-microbiota phyla composition from fecal samples of healthy subjects and both obesity and anorexic patients. Gut microbiota provides nutrients and energy for the host through the products of substrate fermentation in Short Chain Fatty Acids. The motivation that leads us to get involved in this project is to provide to scientific community and industries a convenient and standardized methodology of isolation and cultivation of microbiota from human fecal microbiota transplantation. Goc-MM would supply an experimental model that provides epithelial cells and microbiota to be cultured in presence of physiologically relevant flow and peristalsis like mechanical deformations, which promotes formation of epithelial cells of small intestine. Thanks to the clinical approach of Goc-MM, we will evaluate the different characteristic in the obesity on male and female. Targeting microbiota may represent a new perspective to prevent, reverse or treat obesity, anorexia and other metabolic disorders.


Net EU contribution
€ 184 707,84
2eme etage, halls a-b et c14 rue de la beaune
93100 Montreuil

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Ile-de-France Ile-de-France Seine-Saint-Denis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00