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Physiological consequences of Protocadherin-10 sumoylation on neuronal function.

Project description

Molecular insight into synapse elimination

Synapses are the main neurological structures responsible for the formation of neural circuits and the transmission of information between neurons. Under physiological conditions, the formation and elimination of synapses supports neuronal plasticity. The EU-funded SUMO-PCDH10 project aims to dissect the mechanism of synapse elimination and identify the key determinants. Researchers will focus on protocadherin-10 (PCDH10), an autism-related cell adhesion transmembrane protein known to regulate synapse density and function. They will investigate how a specific post-translational modification known as sumoylation is responsible for PCDH10 function. Given that several neurodevelopmental disorders are associated with synapse elimination, results will have profound clinical consequences.

Coordinator

HUMANITAS MIRASOLE SPA
Net EU contribution
€ 171 473,28
Address
Via Manzoni 56
20100 Rozzano (Mi)
Italy

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Region
Nord-Ovest Lombardia Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00