Physiological consequences of Protocadherin-10 sumoylation on neuronal function.

Project description

Molecular insight into synapse elimination

Synapses are the main neurological structures responsible for the formation of neural circuits and the transmission of information between neurons. Under physiological conditions, the formation and elimination of synapses supports neuronal plasticity. The EU-funded SUMO-PCDH10 project aims to dissect the mechanism of synapse elimination and identify the key determinants. Researchers will focus on protocadherin-10 (PCDH10), an autism-related cell adhesion transmembrane protein known to regulate synapse density and function. They will investigate how a specific post-translational modification known as sumoylation is responsible for PCDH10 function. Given that several neurodevelopmental disorders are associated with synapse elimination, results will have profound clinical consequences.

Fields of science

• natural sciences › biological sciences › neurobiology
• natural sciences › biological sciences › cell biology

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2018 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2018

See other projects for this call

Funding Scheme

MSCA-IF-EF-SE - Society and Enterprise panel

Coordinator

HUMANITAS MIRASOLE SPA

Net EU contribution

€ 171 473,28

Address

Via Manzoni 56
20100 Rozzano (Mi)
Italy

Region

Nord-Ovest › Lombardia › Milano

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

Links

Non-EU contribution

€ 0,00