Project description
Genomic surveillance of typhoid fever
Every year, there are millions of typhoid fever cases in the world. With antimicrobial therapy being the only treatment option, emerging drug resistance must be contained and prevented from spreading to other neighbouring countries. For this purpose, the EU-funded TyphiNET project will employ a genomics epidemiology approach to assist sentinel and endemic areas surveillance for Salmonella typhi. The scope is to obtain information on specific strain prevalence, antimicrobial resistance and regional transmission patterns. TyphiNET will share this data through an open-access publicly available platform, improving disease management and guiding antimicrobial choice.
Objective
Globally there are ~20 million typhoid fever cases per year, resulting in ~200,000 deaths from infection with the causative agent, Salmonella Typhi. Antimicrobial therapy is the mainstay of typhoid fever control, and genomic epidemiology studies have revealed that drug resistance emerging in one country can rapidly spread to other neighbouring countries and intercontinentally. Genomic and phenotypic surveillance for typhoid and antimicrobial resistance (AMR) is therefore very important for disease control. TyphiNET aims to develop innovative approaches to bring the benefits of typhoid genomic surveillance to LMICs where the disease is endemic through three main goals: (1) to unlock data from travel-associated typhoid cases in high income countries that are adopting genomics for routine Salmonella surveillance (2) to unlock data from project-based genomic surveillance in endemic areas (beginning with five key collaborative projects across Asia and Africa) and (3) develop an open access publicly available platform for synergising, visualising, and disseminating large scale genomic data sourced from sentinel and endemic area surveillance. Research questions will include inferring genomic epidemiology parameters (prevalence of strain types, resistance to specific antimicrobials, and regional transmission patterns) for different countries/regions using data from sentinel surveillance and from endemic area surveillance; comparison of these to demonstrate the utility of sentinel traveller surveillance for predicting endemic area disease patterns; and comparison of disease dynamics between regions. Outcomes will inform management of both endemic disease in LMICs and travel-associated cases elsewhere, including providing region- and country-specific data to inform empirical antimicrobial choice; and will reveal coverage gaps in endemic area surveillance to be targeted in future studies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- medical and health sciences health sciences public health epidemiology
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance antibiotic resistance
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2018
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
WC1E 7HT LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.