Revealing novel molecular mechanisms linking DNA replication and cell fate decisions

Project description

Understanding what makes cells change their identity

Our cells carry the code for all the proteins our body makes. However, each cell type makes only those proteins required for its function. During normal development or abnormal processes such as cancer, a cell changes its identity during cell division. At this time, chromatin condenses, copies of the code are made, and they are passed on to the daughter cells. The window between chromatin condensation and chromatin reorganisation represents an important opportunity for reprogramming. The RepDiff project plans to compare proteins in undifferentiated cells that remain pluripotent after cell division with those in cells that take on new identities. Insight will have broad-reaching impact on normal and abnormal cell fate transitions.

Fields of science

• natural sciences › biological sciences › biochemistry › biomolecules › proteins › proteomics
• natural sciences › biological sciences › genetics › DNA
• medical and health sciences › medical biotechnology › cells technologies › stem cells
• medical and health sciences › clinical medicine › oncology
• natural sciences › biological sciences › genetics › epigenetics

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2018 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2018

See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

KOBENHAVNS UNIVERSITET

Net EU contribution

€ 219 312,00

Address

Norregade 10
1165 Kobenhavn
Denmark

Region

Danmark › Hovedstaden › Byen København

Activity type

Higher or Secondary Education Establishments

Links

Non-EU contribution

€ 0,00