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Revealing novel molecular mechanisms linking DNA replication and cell fate decisions

Project description

Understanding what makes cells change their identity

Our cells carry the code for all the proteins our body makes. However, each cell type makes only those proteins required for its function. During normal development or abnormal processes such as cancer, a cell changes its identity during cell division. At this time, chromatin condenses, copies of the code are made, and they are passed on to the daughter cells. The window between chromatin condensation and chromatin reorganisation represents an important opportunity for reprogramming. The RepDiff project plans to compare proteins in undifferentiated cells that remain pluripotent after cell division with those in cells that take on new identities. Insight will have broad-reaching impact on normal and abnormal cell fate transitions.

Coordinator

KOBENHAVNS UNIVERSITET
Net EU contribution
€ 219 312,00
Address
Norregade 10
1165 Kobenhavn
Denmark

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Region
Danmark Hovedstaden Byen København
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00