Neoantigenic properties of TP53 variants influence cancer risk in individuals with Li-Fraumeni syndrome
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Author(s):
Emilie Montellier, Olivier Manches, Jonathan Gaucher, Claire Freycon, David Hoyos, Sandrine Blanchet, Murielle Verboom, Christina M. Dutzmann, Sophie Coutant, Jacqueline Bou, Bertrand Fin, Robert Olaso, Jean-François Deleuze, Thierry Frébourg, Benjamin D. Greenbaum, Arnold J. Levine, Christian P. Kratz, Gaëlle Bougeard, Pierre Hainaut
Published in:
eBioMedicine, Issue 123, 2026, Page(s) 106065, ISSN 2352-3964
Publisher:
Elsevier BV
DOI:
10.1016/j.ebiom.2025.106065
Clustering of TP53 variants into functional classes correlates with cancer risk and identifies different phenotypes of Li-Fraumeni syndrome
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Author(s):
Emilie Montellier, Nathanaël Lemonnier, Judith Penkert, Claire Freycon, Sandrine Blanchet, Amina Amadou, Florent Chuffart, Nicholas W. Fischer, Maria-Isabel Achatz, Arnold J. Levine, Catherine Goudie, David Malkin, Gaëlle Bougeard, Christian P. Kratz, Pierre Hainaut
Published in:
iScience, Issue 27, 2024, Page(s) 111296, ISSN 2589-0042
Publisher:
Cell Press
DOI:
10.1016/j.isci.2024.111296