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Health effects of cArdiac fluoRoscopy and MOderN radIotherapy in paediatriCs

Objective

The increasing use of radiation-associated diagnostic and therapeutic procedures have contributed to the improvements of early diagnosis and survival of paediatric patients. While benefits to the patient outweigh the radiation associated risk, the late effects of exposure of children are particularly important to understand in populations with increased survival.
The HARMONIC project builds on close collaboration between scientific and medical communities to contribute to improvements in the understanding of the health effects of medical ionising radiation exposure of paediatric patients, focusing on two distinct and complementary populations: (1) Paediatric patients undergoing modern radiotherapy (including proton therapy); (2) Paediatric patients undergoing interventional cardiology. Our project will provide additional insight into exposure to ionising radiation in childhood, exploring potential effects at very early ages, exposure to a wide range of doses from photons, protons and secondary neutrons radiation.
We aim at building European cohorts and registries for long term follow-up of paediatric patients treated with ionising radiation, both in cardiology and oncology settings, in the context of very rapid technology evolution. The study will use an integrated approach of conventional epidemiology, based on state-of-the art dosimetry, complemented by non-invasive imaging and molecular epidemiology to assess the following outcomes: endocrine dysfunctions, cardio and neurovascular diseases, societal impact and cancer. Complementary to this effort, we propose to investigate radiation-induced cellular responses in samples of blood and saliva, and the mechanisms involved in the processes that may lead to cancer and vascular diseases.
Ultimately, HARMONIC will develop tools and allow definition of guidelines on optimization techniques to guide treatments toward reduction of patient doses in paediatric cardiology and oncology.

Field of science

  • /medical and health sciences/health sciences/epidemiology
  • /medical and health sciences/clinical medicine/paediatrics
  • /medical and health sciences/clinical medicine/angiology/vascular diseases
  • /medical and health sciences/clinical medicine/cardiology/paediatric cardiology
  • /medical and health sciences/clinical medicine/cancer

Call for proposal

NFRP-2018
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA
Address
C Rossello 132 Planta 05
08036 Barcelona
Spain
Activity type
Research Organisations
EU contribution
€ 762 762,50

Participants (23)

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 525 050
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
UNIVERSITAETSKLINIKUM ESSEN
Germany
EU contribution
€ 897 480
Address
Hufelandstrasse 55
45147 Essen
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
EU contribution
€ 439 740
Address
Kings Gate
NE1 7RU Newcastle Upon Tyne
Activity type
Higher or Secondary Education Establishments
INSTITUT DE RADIOPROTECTION ET DE SURETE NUCLEAIRE
France
EU contribution
€ 357 240
Address
Av De La Division Leclerc 31
92260 Fontenay Aux Roses
Activity type
Research Organisations
STUDIECENTRUM VOOR KERNENERGIE / CENTRE D'ETUDE DE L'ENERGIE NUCLEAIRE
Belgium
EU contribution
€ 424 088,75
Address
Avenue Herrmann Debroux 40
1160 Bruxelles
Activity type
Research Organisations
STOCKHOLMS UNIVERSITET
Sweden
EU contribution
€ 239 687,50
Address
Universitetsvagen 10
10691 Stockholm
Activity type
Higher or Secondary Education Establishments
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 171 653,75
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
AARHUS UNIVERSITETSHOSPITAL
Denmark
EU contribution
€ 66 412,50
Address
Palle Juul-jensens Boulevard 99
8200 Aarhus
Activity type
Research Organisations
AARHUS UNIVERSITET
Denmark
EU contribution
€ 241 250
Address
Nordre Ringgade 1
8000 Aarhus C
Activity type
Higher or Secondary Education Establishments
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU contribution
€ 176 215
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
CENTRE REGIONAL FRANCOIS BACLESSE
France
EU contribution
€ 72 750
Address
Avenue Du General Harris 3
14076 Caen Cedex 5
Activity type
Research Organisations
INSTITUT GUSTAVE ROUSSY
France
EU contribution
€ 345 250
Address
Rue Camille Desmoulins 39
94805 Villejuif
Activity type
Research Organisations
LEIBNIZ-INSTITUT FUR PRAVENTIONSFORSCHUNG UND EPIDEMIOLOGIE - BIPS GMBH
Germany
EU contribution
€ 401 625
Address
Achterstrasse 30
28359 Bremen
Activity type
Other
WESTDEUTSCHES PROTONENTHERAPIEZENTRUM ESSEN (WPE) GGMBH
Germany
EU contribution
€ 388 787,50
Address
Hufelandstr. 55
45122 Essen
Activity type
Other
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 295 551,25
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
LUXEMBOURG INSTITUTE OF SCIENCE AND TECHNOLOGY
Luxembourg
EU contribution
€ 324 396,25
Address
5 Avenue Des Hauts Fourneaux
4362 Esch Sur Alzette
Activity type
Research Organisations
PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV
Netherlands
EU contribution
€ 10 000
Address
Heidelberglaan 25
3584CS Utrecht
Activity type
Other
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
EU contribution
€ 10 000
Address
Hanzeplein 1
9713 GZ Groningen
Activity type
Higher or Secondary Education Establishments
OSLO UNIVERSITETSSYKEHUS HF
Norway
EU contribution
€ 148 191,25
Address
Kirkeveien 166 Tarnbygget
0450 Oslo
Activity type
Higher or Secondary Education Establishments
UNIVERSITETET I SOROST-NORGE
Norway
EU contribution
€ 175 572,50
Address
Kjolnes Ring 56
3918 Porsgrunn
Activity type
Higher or Secondary Education Establishments
UNIVERSITAT ZURICH
Switzerland
EU contribution
€ 300 000
Address
Ramistrasse 71
8006 Zurich
Activity type
Higher or Secondary Education Establishments
STATE INSTITUTION RESEARCH CENTER FOR RADIATION MEDICINE OF THE ACADEMY OF MEDICAL SCIENCES OF UKRAINE
Ukraine
EU contribution
€ 148 066,25
Address
Melnikova Street 53
04050 Kyiv
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE CAEN NORMANDIE
France
EU contribution
€ 78 218,75
Address
Esplanade De La Paix
14032 Caen Cedex 5
Activity type
Higher or Secondary Education Establishments