Retinal and cognitive dysfunction in type 2 diabetes: unraveling the common pathways and identification of patients at risk of dementia

Project Information

RECOGNISED

Grant agreement ID: 847749

DOI

10.3030/847749

Project closed

EC signature date 21 November 2019

Start date 1 January 2020

End date 31 December 2024

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 5 998 272,50

EU contribution

€ 5 998 272,50

Coordinated by

FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (1)

Development of the logo and website

Development of the logo and website (Month 3. The website will be updated continuously)

Documents, reports (2)

Communication activities and impact on social media

Report on communication activities and impact on social media (Month 60)

Dissemination and networking activities

Report on dissemination (including publications) and networking activities (Month 24, 36, 60)

Publications

Peer reviewed articles (10)

Aldehyde Dehydrogenase and Aldo-Keto Reductase Enzymes: Basic Concepts and Emerging Roles in Diabetic Retinopathy

Author(s): Burak Mugdat Karan, Karis Little, Josy Augustine, Alan W. Stitt, Tim M. Curtis
Published in: Antioxidants, Issue 12, 2023, Page(s) 1466, ISSN 2076-3921
Publisher: Antioxidants
DOI: 10.3390/antiox12071466

JNK Activation Correlates with Cognitive Impairment and Alteration of the Post-Synaptic Element in the 5xFAD AD Mouse Model

Author(s): Erica Cecilia Priori, Clara Alice Musi, Arianna Giani, Luca Colnaghi, Ivana Milic, Andrew Devitt, Tiziana Borsello, Mariaelena Repici
Published in: Cells, Issue 12, 2023, Page(s) 904, ISSN 2073-4409
Publisher: Cells
DOI: 10.3390/cells12060904

JNK signaling provides a novel therapeutic target for Rett syndrome

Author(s): Clara Alice Musi; Anna Maria Castaldo; Anna Elisa Valsecchi; Sara Cimini; Noemi Morello; Riccardo Pizzo; Alessandra Renieri; Ilaria Meloni; Maurizio Bonati; Maurizio Giustetto; Tiziana Borsello
Published in: BMC Biology, Issue 19, 16.12.2021, 2021, Page(s) 256, ISSN 1741-7007
Publisher: BioMed Central
DOI: 10.1186/s12915-021-01190-2

JNK3 as Therapeutic Target and Biomarker in Neurodegenerative and Neurodevelopmental Brain Diseases

Author(s): Clara Alice Musi; Clara Alice Musi; Graziella Agrò; Francesco Santarella; Erika Iervasi; Erika Iervasi; Tiziana Borsello
Published in: Cells, Issue 9, 28.9.2020, 2020, Page(s) 2190, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells9102190

Common pathways in dementia and diabetic retinopathy: understanding the mechanisms of diabetes-related cognitive decline

Author(s): Karis Little, María Llorián-Salvador, Sarah Scullion, Cristina Hernández, Olga Simó-Servat, Angel del Marco, Esmeralda Bosma, Maria Vargas-Soria, Maria Jose Carranza-Naval, Tine Van Bergen, Silvia Galbiati, Ilaria Viganò, Clara Alice Musi, Reiner Schlingemann, Jean Feyen, Tiziana Borsello, Gianpaolo Zerbini, Ingeborg Klaassen, Monica Garcia-Alloza, Rafael Simó, Alan W. Stitt
Published in: Trends in Endocrinology & Metabolism, Issue 33, 2023, Page(s) 50-71, ISSN 1043-2760
Publisher: Elsevier BV
DOI: 10.1016/j.tem.2021.10.008

Effect of 3D Synthetic Microscaffold Nichoid on the Morphology of Cultured Hippocampal Neurons and Astrocytes

Author(s): Clara Alice Musi; Luca Colnaghi; Arianna Giani; Erica Cecilia Priori; Giacomo Marchini; Matteo Tironi; Claudio Conci; Giulio Cerullo; Roberto Osellame; Manuela Teresa Raimondi; Andrea Remuzzi; Tiziana Borsello
Published in: Cells, Issue 11, 2022, Page(s) 2008, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells11132008

Structural and Metabolic Retinal Changes Associated With Mild Cognitive Impairment in Type 2 Diabetes

Author(s): Frederik N. Pedersen, Lonny Stokholm, Noemi Lois, Dawei Yang, Carol Y. Cheung, Geert Jan Biessels, Lieza Exalto, Rafael Simó, Tunde Peto, Frans Pouwer, Jakob Grauslund
Published in: Diabetes, Issue 72, 2023, Page(s) 1853-1863, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db23-0025

Disruption of cortical cell type composition and function underlies diabetes-associated cognitive decline

Author(s): Karis Little, Aditi Singh, Angel Del Marco, María Llorián-Salvador, Maria Vargas-Soria, Mireia Turch-Anguera, Montse Solé, Noëlle Bakker, Sarah Scullion, Joan X. Comella, Ingeborg Klaassen, Rafael Simó, Monica Garcia-Alloza, Vijay K. Tiwari, Alan W. Stitt, null null
Published in: Diabetologia, Issue 66, 2023, Page(s) 1557-1575, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-023-05935-2

Accelerated amyloid angiopathy and related vascular alterations in a mixed murine model of Alzheimer´s disease and type two diabetes

Author(s): Maria Vargas-Soria; Juan Jose Ramos-Rodriguez; Angel del Marco; Carmen Hierro-Bujalance; Maria Jose Carranza-Naval; Maria Calvo-Rodriguez; Susanne J. van Veluw; Alan W. Stitt; Rafael Simó; Brian J. Bacskai; Carmen Infante-Garcia; Monica Garcia-Alloza
Published in: Fluids and Barriers of the CNS, Issue 19, 7.11.2022, 2022, Page(s) 88, ISSN 2045-8118
Publisher: BioMed Central
DOI: 10.1186/s12987-022-00380-6

Revisiting the Montreal Cognitive Assessment in a European cohort of elderly living with type 2 diabetes

Author(s): Natasa Popovic, Noemi Lois, Santiago Pérez-Hoyos, Rafael Simó, Lieza G Exalto, null null
Published in: Journal of Alzheimer’s Disease, 2025, ISSN 1387-2877
Publisher: IOS Press
DOI: 10.1177/13872877251318029