CORDIS - EU research results
CORDIS

DIGITAL, RISK-BASED SCREENING FOR ATRIAL FIBRILLATION IN THE EUROPEAN COMMUNITY

Deliverables

Comprehensive and systematic review of economic evaluation literature of AF screening

Task 41 The development of a new decision analytic model including a variety of screening technologies with updated parameters of risks effects and costs Partners LIU MAC Duration months 1 24 Deliverables D41 42WP4s economic evaluations of screening programmes will assess the costs and consequences of broad management pathways encompassing the invitation and attendance to the screening tests interpretation of test results decision treatment or surveillance and implementation of chosen treatments In order to provide good value for money the cost of inviting an often large number of individuals to the screening tests must be reasonable in relation to the health benefits gained by treating a limited number of individuals Decisionanalytic modelling will be utilised to analyse this relationship in the costeffectiveness analyses of AFFECTEUs diverse screening programmes parameters will involve screening specific information such as attendance rates test characteristics decisionalteration parameters and the effect of implemented treatments themselves42 43 The decision analytic model will integrate data from WP1 WP2 WP3 which will provide new evidence on the stroke risk equation updated parameters on the prognosis of screendetected AF effectiveness and adherence of OAC treatment actual cost data for the different screening technologiesprocedures medical workup and longterm cost and effects of AF related complications including QoL Our new model will be informed by the finding in AFFECTEU and a systematic literature review and in addition to thromboembolic events also include other preventable AF comorbidities eg heart failure myocardial infarction and dementia The information on QoL available in all studies of the proposal will be integrated into the model improving the estimation of QoL in different screening strategiesWP2 results will permit other testsbiomarkersgenetics to enter the economic modelling which has the potential of improving the prognostic value of the screening strategies as well as the costeffectiveness due to better patient selection

Review of contemporary data sources and the literature for AF screening studies

WP1 will systematically identify all available biomedical AF screening study sources comprehensively characterize them for the research proposed in the consortium Table 11 Data in two outcome trials powered by primary care Danish LOOP SAFER are complemented by five clinical studies with different depth of additional phenotyping 200000 individuals Step 1 AFFECTEU will establish a data inventory by comprehensively characterizing the available data sources for accessibility size of dataset ie availability of risk factorshealth determinants number and type of blood samples spectrum of data collected selfreported data electronic health records clinical lifestyle imaging epigenetic and omics information type and duration of followup Important information will be the type and characteristics of screening the device applied the accuracy of AF diagnosis completeness of rhythm monitoring and additional details related to the screening process itself including barriers to screening Patientreported outcome measures POEMs PatientOriented Evidence that Matters quality of life and potential harms by screening and the inconveniences of the screening procedure itself will be captured A minimum of patientcentred outcomes data comprising patientreported clinicianreported and administrative metrics as well as outcome metrics for POEMs outcomes relevant for providerspayersregulators will be suggested for harmonization All partners will provide an overview of their data collection and variable manuals that will be harmonized and compiled in a central data base Interactive retrieval tools WP 6 will support the exploitation of variables through the established catalogue to get summary information and understand similarities and differences between the diverse studiesStep 2 A working platform for efficient data retrieval and exchange will be established technically supported by WP6

Catalogue detailing the available datasets and associated variables in the consortium

WP1 will systematically identify all available biomedical AF screening study sources comprehensively characterize them for the research proposed in the consortium Table 11 Data in three outcome trials powered for strokeSE 160000 participants in the community STROKESTOP studies and primary care Danish LOOP SAFER are complemented by five clinical studies with different depth of additional phenotyping 200000 individuals Step 1 AFFECTEU will establish a data inventory by comprehensively characterizing the available data sources for accessibility size of dataset ie availability of risk factorshealth determinants number and type of blood samples spectrum of data collected selfreported data electronic health records clinical lifestyle imaging epigenetic and omics information type and duration of followup Important information will be the type and characteristics of screening the device applied the accuracy of AF diagnosis completeness of rhythm monitoring and additional details related to the screening process itself including barriers to screening Patientreported outcome measures POEMs PatientOriented Evidence that Matters quality of life and potential harms by screening and the inconveniences of the screening procedure itself will be captured A minimum of patientcentred outcomes data comprising patientreported clinicianreported and administrative metrics as well as outcome metrics for POEMs outcomes relevant for providerspayersregulators will be suggested for harmonization All partners will provide an overview of their data collection and variable manuals that will be harmonized and compiled in a central data base Interactive retrieval tools WP 6 will support the exploitation of variables through the established catalogue to get summary information and understand similarities and differences between the diverse studiesStep 2 A working platform for efficient data retrieval and exchange will be established technically supported by WP6

Publications

Advancing Research on the Complex Interrelations Between Atrial Fibrillation and Heart Failure

Author(s): Sana M. Al-Khatib, Emelia J. Benjamin, Christine M. Albert, Alvaro Alonso, Cynthia Chauhan, Peng-Sheng Chen, Anne B. Curtis, Patrice Desvigne-Nickens, Jennifer E. Ho, Carolyn S.P. Lam, Mark S. Link, Kristen K. Patton, Margaret M. Redfield, Michiel Rienstra, Yves Rosenberg, Renate Schnabel, John A. Spertus, Lynne Warner Stevenson, Mellanie True Hills, Adriaan A. Voors, Lawton S. Cooper, Alan S. Go
Published in: Circulation, Issue 141/23, 2020, Page(s) 1915-1926, ISSN 0009-7322
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.119.045204

Risk prediction of atrial fibrillation in the community combining biomarkers and genetics

Author(s): Christin S Börschel, Amelie H Ohlrogge, Bastiaan Geelhoed, Teemu Niiranen, Aki S Havulinna, Tarja Palosaari, Pekka Jousilahti, Michiel Rienstra, Pim van der Harst, Stefan Blankenberg, Tanja Zeller, Veikko Salomaa, Renate B Schnabel
Published in: EP Europace, 2021, ISSN 1099-5129
Publisher: Oxford University Press
DOI: 10.1093/europace/euaa334

Temporal relations between atrial fibrillation and ischaemic stroke and their prognostic impact on mortality

Author(s): Stephan Camen, Francisco M Ojeda, Teemu Niiranen, Francesco Gianfagna, Julie K Vishram-Nielsen, Simona Costanzo, Stefan Söderberg, Erkki Vartiainen, Maria Benedetta Donati, Maja-Lisa Løchen, Gerard Pasterkamp, Christina Magnussen, Frank Kee, Pekka Jousilahti, Maria Hughes, Jukka Kontto, Ellisiv B Mathiesen, Wolfgang Koenig, Tarja Palosaari, Stefan Blankenberg, Giovanni de Gaetano, Torben Jørgen
Published in: EP Europace, Issue 22/4, 2019, Page(s) 522-529, ISSN 1099-5129
Publisher: Oxford University Press
DOI: 10.1093/europace/euz312

Why do people take part in atrial fibrillation screening? Qualitative interview study in English primary care

Author(s): Sarah Hoare, Alison Powell, Rakesh Modi, Natalie Armstrong, Simon Griffin, Jonathan Mant, Jenni Burt
Published in: BMJ Open, 2022, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjopen-2021-051703

Effects of systematic atrial fibrillation screening according to N-terminal pro-B-type natriuretic peptide: a secondary analysis of the randomized LOOP study

Author(s): Lucas Yixi Xing, Søren Zöga Diederichsen, Søren Højberg, Derk W Krieger, Claus Graff, Ruth Frikke-Schmidt, Morten S Olesen, Axel Brandes, Lars Køber, Ketil Jørgen Haugan, Jesper Hastrup Svendsen
Published in: Circulation, 2023, ISSN 0009-7322
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.123.064361

Vorhofflimmern und kognitive Störung – Bedeutung für die Geriatrie

Author(s): Alexander Rösler, Renate Schnabel
Published in: Zeitschrift für Gerontologie und Geriatrie, 2020, ISSN 0948-6704
Publisher: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00391-020-01754-x

Diabetes status-related differences in risk factors and mediators of heart failure in the general population: results from the MORGAM/BiomarCaRE consortium

Author(s): Vuori MA, Reinikainen J, Söderberg S, Bergdahl E, Jousilahti P, Tunstall-Pedoe H, Zeller T, Westermann D, Sans S, Linneberg A, Iacoviello L, Costanzo S, Salomaa V, Blankenberg S, Kuulasmaa K, Niiranen TJ.
Published in: Cardiovascular Diabetology, 2021, ISSN 1475-2840
Publisher: BioMed Central
DOI: 10.1186/s12933-021-01378-4

Polygenic Risk Scores for Predicting Adverse Outcomes After Coronary Revascularization.

Author(s): Aittokallio J, Kauko A, Vaura F, Salomaa V, Kiviniemi T; FinnGen; Schnabel RB, Niiranen T.
Published in: Am. J. Cardiol., 2022, ISSN 0002-9149
Publisher: Excerpta Medica, Inc.
DOI: 10.1016/j.amjcard.2021.11.046

Antithrombotic management and outcomes of patients with atrial fibrillation treated with NOACs early at the time of market introduction: Main results from the PREFER in AF Prolongation Registry

Author(s): Giulia Renda, Ladislav Pecen, Giuseppe Patti, Fabrizio Ricci, Dipak Kotecha, Jolanta M. Siller-Matula, Renate B. Schnabel, Rolf Wachter, Jean-Marc Sellal, Miklos Rohla, Markus Lucerna, Kurt Huber, Freek W. A. Verheugt, Jose Luis Zamorano, Bernd Brüggenjürgen, Harald Darius, Mattias Duytschaever, Jean-Yves Le Heuzey, Richard J. Schilling, Paulus Kirchhof, Raffaele De Caterina
Published in: Internal and Emergency Medicine, 2020, ISSN 1828-0447
Publisher: CEPI-AIM Group
DOI: 10.1007/s11739-020-02442-9

Cardiac Troponin I and Incident Stroke in European Cohorts

Author(s): Stephan Camen, Tarja Palosaari, Jaakko Reinikainen, Ngoc Anh Sprünker, Teemu Niiranen, Francesco Gianfagna, Julie K.K. Vishram-Nielsen, Simona Costanzo, Stefan Söderberg, Luigi Palmieri, Marco Ferrario, Annette Peters, Erkki Vartiainen, Maria Benedetta Donati, Chiara Donfrancesco, Rossana Borchini, Christin Susanna Börschel, Simona Giampaoli, Augusto Di Castelnuovo, Christina Magnussen, Frank K
Published in: Stroke, Issue 51/9, 2020, Page(s) 2770-2777, ISSN 0039-2499
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.120.029452

Risk Factors, Subsequent Disease Onset, and Prognostic Impact of Myocardial Infarction and Atrial Fibrillation.

Author(s): Camen S, Csengeri D, Geelhoed B, Niiranen T, Gianfagna F, Vishram-Nielsen JK, Costanzo S, Söderberg S, Vartiainen E, Börschel CS, Donati MB, Løchen ML, Ojeda FM, Kontto J, Mathiesen EB, Jensen S, Koenig W, Kee F, de Gaetano G, Zeller T, Jørgensen T, Tunstall-Pedoe H, Blankenberg S, Kuulasmaa K, Linneberg A, Salomaa V, Iacoviello L, Schnabel RB.
Published in: J. Am. Heart Assoc., 2022, ISSN 2047-9980
Publisher: Wiley-Blackwell
DOI: 10.1161/jaha.121.024299

Assessment of causality of natriuretic peptides and atrial fibrillation and heart failure: a Mendelian randomization study in the FINRISK cohort

Author(s): Bastiaan Geelhoed, Christin S Börschel, Teemu Niiranen, Tarja Palosaari, Aki S Havulinna, Césaire J K Fouodo, Markus O Scheinhardt, Stefan Blankenberg, Pekka Jousilahti, Kari Kuulasmaa, Tanja Zeller, Veikko Salomaa, Renate B Schnabel
Published in: EP Europace, Issue 22/10, 2020, Page(s) 1463-1469, ISSN 1099-5129
Publisher: Oxford University Press
DOI: 10.1093/europace/euaa158

Influence of geographical latitude on vitamin D status: cross-sectional results from the BiomarCaRE consortium

Author(s): Oskarsson V, Eliasson M, Salomaa V, Reinikainen J, Männistö S, Palmieri L, Donfrancesco C, Sans S, Costanzo S, de Gaetano G, Iacoviello L, Veronesi G, Ferrario MM, Padro T, Thorand B, Huth C, Zeller T, Blankenberg S, Anderson AS, Tunstall-Pedoe H, Kuulasmaa K, Söderberg S; BiomarCaRE investigators.
Published in: Br J Nutr, 2022, ISSN 0007-1145
Publisher: CABI Publishing
DOI: 10.1017/s0007114521005080

Consumer-led screening for atrial fibrillation using consumer-facing wearables, devices and apps: A survey of health care professionals by AF-SCREEN international collaboration

Author(s): Giuseppe Boriani, Renate B Schnabel, Jeff S Healey, Renato D Lopes, Nicole Verbiest-van Gurp, Trudie Lobban, John A Camm, Ben Freedman
Published in: European Journal of Internal Medicine, Issue 82, 2020, Page(s) 97-104, ISSN 0953-6205
Publisher: Elsevier BV
DOI: 10.1016/j.ejim.2020.09.005

Risk prediction of atrial fibrillation and its complications in the community using hs troponin I.

Author(s): Börschel CS, Geelhoed B, Niiranen T, Camen S, Donati MB, Havulinna AS, Gianfagna F, Palosaari T, Jousilahti P, Kontto J, Vartiainen E, Ojeda FM, den Ruijter HM, Costanzo S, de Gaetano G, Di Castelnuovo A, Linneberg A, Vishram-Nielsen JK, Løchen ML, Koenig W, Jørgensen T, Kuulasmaa K, Blankenberg S, Iacoviello L, Zeller T, Söderberg S, Salomaa V, Schnabel RB.
Published in: Eur. J. Clin. Invest., 2023, ISSN 0014-2972
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/eci.13950

Neck Circumference and Risk of Incident Atrial Fibrillation in the Framingham Heart Study.

Author(s): Jelena Kornej, Honghuang Lin, Ludovic Trinquart, Corban R Jackson, Darae Ko, Emelia J Benjamin, Sarah R Preis
Published in: J Am Heart Assoc, 2023, ISSN 2047-9980
Publisher: Wiley-Blackwell
DOI: 10.1161/jaha.121.022340

The association between eicosanoids and incident atrial fibrillation in the Framingham Heart Study

Author(s): Jelena Kornej, Maha A Qadan, Mona Alotaibi, David R Van Wagoner, Jeramie D Watrous, Ludovic Trinquart, Sarah R Preis, Darae Ko, Mohit Jain, Emelia J Benjamin, Susan Cheng, Honghuang Lin
Published in: Scientific Reports, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-21786-0

Clinical Factors Associated with Atrial Fibrillation Detection on Single-Time Point Screening Using a Hand-Held Single-Lead ECG Device

Author(s): Giuseppe Boriani, Pietro Palmisano, Vincenzo Livio Malavasi, Elisa Fantecchi, Marco Vitolo, Niccolo’ Bonini, Jacopo F. Imberti, Anna Chiara Valenti, Renate B. Schnabel, Ben Freedman
Published in: Journal of Clinical Medicine, Issue 10/4, 2021, Page(s) 729, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm10040729

Digital, risk-based screening for atrial fibrillation in the European community—the AFFECT-EU project funded by the European Union

Author(s): Daniel Engler, Hein Heidbuchel, Renate B Schnabel
Published in: European Heart Journal, 2021, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehab050

Age-specific atrial fibrillation incidence, attributable risk factors and risk of stroke and mortality: results from the MORGAM Consortium

Author(s): Bente Morseth, Bastiaan Geelhoed, Allan Linneberg, Lars Johansson, Kari Kuulasmaa, Veikko Salomaa, Licia Iacoviello, Simona Costanzo, Stefan Söderberg, Teemu J Niiranen, Julie K K Vishram-Nielsen, Inger Njølstad, Tom Wilsgaard, Ellisiv B Mathiesen, Maja-Lisa Løchen, Tanja Zeller, Stefan Blankenberg, Francisco M Ojeda, Renate B Schnabel
Published in: Open Heart, Issue 8/2, 2021, Page(s) e001624, ISSN 2053-3624
Publisher: BMJ
DOI: 10.1136/openhrt-2021-001624

Exploring the incremental utility of circulating biomarkers for robust risk prediction of incident atrial fibrillation in European cohorts using regressions and modern machine learning methods.

Author(s): Toprak B, Brandt S, Brederecke J, Gianfagna F, Vishram-Nielsen JKK, Ojeda FM, Costanzo S, Börschel CS, Söderberg S, Katsoularis I, Camen S, Vartiainen E, Donati MB, Kontto J, Bobak M, Mathiesen EB, Linneberg A, Koenig W, Løchen ML, Di Castelnuovo A, Blankenberg S, de Gaetano G, Kuulasmaa K, Salomaa V, Iacoviello L, Niiranen T, Zeller T, Schnabel RB.
Published in: Europace, 2023, ISSN 1532-2092
Publisher: Oxford University Press
DOI: 10.1093/europace/euac260

Cognitive impairment in patients with atrial fibrillation: Implications for outcome in a cohort study

Author(s): Vincenzo Livio Malavasi, Cristina Zoccali, Maria Chiara Brandi, Giulia Micali, Marco Vitolo, Jacopo Francesco Imberti, Chiara Mussi, Renate B. Schnabel, Ben Freedman, Giuseppe Boriani
Published in: International Journal of Cardiology, Issue 323, 2021, Page(s) 83-89, ISSN 0167-5273
Publisher: Elsevier BV
DOI: 10.1016/j.ijcard.2020.08.028

Epidemiology of Atrial Fibrillation in the 21st Century

Author(s): Jelena Kornej, Christin S. Börschel, Emelia J. Benjamin, Renate B. Schnabel
Published in: Circulation Research, Issue 127/1, 2020, Page(s) 4-20, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.120.316340

Simple cardiovascular risk stratification by replacing total serum cholesterol with anthropometric measures: The MORGAM prospective cohort project

Author(s): Rosberg V, Vishram-Nielsen JK, Kristensen AMD, Pareek M, Sehested TSG, Nilsson PM, Linneberg A, Palmieri L, Giampaoli S, Donfrancesco C, Kee F, Mancia G, Cesana G, Veronesi G, Grassi G, Kuulasmaa K, Salomaa V, Palosaari T, Sans S, Ferrieres J, Dallongeville J, Söderberg S, Moitry M, Drygas W, Tamosiunas A, Peters A, Brenner H, Schöttker B, Grimsgaard S, Biering-Sørensen T, Olsen MH.
Published in: Prev Med Rep, 2022, ISSN 2211-3355
Publisher: Elsevier BV
DOI: 10.1016/j.pmedr.2022.101700

Natriuretic Peptides and Risk of Type 2 Diabetes: Results From the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) Consortium

Author(s): Sujana C, Salomaa V, Kee F, Costanzo S, Söderberg S, Jordan J, Jousilahti P, Neville C, Iacoviello L, Oskarsson V, Westermann D, Koenig W, Kuulasmaa K, Reinikainen J, Blankenberg S, B; BiomarCaRE Consortium. Zeller T, Herder C, Mansmann U, Peters A, Thorand
Published in: Diabetes Care, 2021, ISSN 0149-5992
Publisher: American Diabetes Association
DOI: 10.2337/dc21-0811

Atrial fibrillation: villain or bystander in vascular brain injury

Author(s): Ben Freedman, Hooman Kamel, Isabelle C Van Gelder, Renate B Schnabel
Published in: European Heart Journal Supplements, Issue 22/Supplement_M, 2020, Page(s) M51-M59, ISSN 1520-765X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/suaa166

How to embed qualitative research in trials: insights from the feasibility study of the SAFER trial programme

Author(s): Alison Powell, Sarah Hoars, Rakesh Modi, Kate Williams, Andrew Dymond, Cheryl Chapman, Simon Griffon, Jonathan Mant, Jenni Burt
Published in: Trials, 2022, ISSN 1745-6215
Publisher: BioMed Central
DOI: 10.1186/s13063-022-06308-7

Diversity 4.0 in the cardiovascular health-care workforce

Author(s): Renate B. Schnabel, Emelia J. Benjamin
Published in: Nature Reviews Cardiology, Issue 17/12, 2020, Page(s) 751-753, ISSN 1759-5002
Publisher: Nature Publishing Group
DOI: 10.1038/s41569-020-00462-8

Refined atrial fibrillation screening and cost-effectiveness in the German population

Author(s): Renate B Schnabel, Christopher Wallenhorst, Daniel Engler, Stefan Blankenberg, Norbert Pfeiffer, Ngoc Anh Spruenker, Matthias Buettner, Matthias Michal, Karl J Lackner, Thomas Münzel, Philipp S Wild, Carlos Martinez, Ben Freedman
Published in: Heart, 2021, Page(s) heartjnl-2020-318882, ISSN 1355-6037
Publisher: BMJ Publishing Group
DOI: 10.1136/heartjnl-2020-318882

Inflammatory proteomics profiling for prediction of incident atrial fibrillation.

Author(s): Börschel CS, Ortega-Alonso A, Havulinna AS, Jousilahti P, Salmi M, Jalkanen S, Veikko S, Niiranen T, Schnabel RB.
Published in: Heart, 2023, ISSN 1355-6037
Publisher: BMJ Publishing Group
DOI: 10.1136/heartjnl-2022-321959

Prediction models for atrial fibrillation applicable in the community: a systematic review and meta-analysis

Author(s): Jelle C L Himmelreich, Lieke Veelers, Wim A M Lucassen, Renate B Schnabel, Michiel Rienstra, Henk C P M van Weert, Ralf E Harskamp
Published in: EP Europace, Issue 22/5, 2020, Page(s) 684-694, ISSN 1099-5129
Publisher: Oxford University Press
DOI: 10.1093/europace/euaa005

Cluster randomised controlled trial of screening for atrial fibrillation in people aged 70 years and over to reduce stroke: protocol for the pilot study for the SAFER trial

Author(s): Kate Williams, Rakesh Modi, Andrew Dymond, Sarah Hoare. Alison Powell, Jenni Burt, Duncan Edwards, Jenny Lund, Rachel Johnson, Trudie Lobban, Mark Lown, Michael Sweeting, H Thom, Stephen Kaptoge, Francesco Fusco, Stephen Morris, Gregory Lip, Natalie Armstrong, Martin Cowie, David Fitzmaurice, Ben Freedman, Simon Griffin, Stephen Sutton, Richard Hobbs, Richard McManus, Jonathan Mant
Published in: BMJ Open, 2022, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjopen-2022-065066

Integrated care in stroke survivors: When and how much?

Author(s): Renate B. Schnabel, Götz Thomalla, Paulus Kirchhof
Published in: EClinicalMedicine, Issue 25, 2020, Page(s) 100489, ISSN 2589-5370
Publisher: spinger
DOI: 10.1016/j.eclinm.2020.100489

Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation: the 8th AFNET/EHRA consensus conference.

Author(s): Schnabel RB, Marinelli EA, Arbelo E, Boriani G, Boveda S, Buckley CM, Camm AJ, Casadei B, Chua W, Dagres N, de Melis M, Desteghe L, Diederichsen SZ, Duncker D, Eckardt L, Eisert C, Engler D, Fabritz L, Freedman B, Gillet L, Goette A, Guasch E, Svendsen JH, Hatem SN, Haeusler KG, Healey JS, Heidbuchel H, Hindricks G, Hobbs FDR, Hübner T, Kotecha D, Krekler M, Leclercq C, Lewalter T, Lin H, Linz D,
Published in: Europace, 2023, ISSN 1099-5129
Publisher: Oxford University Press
DOI: 10.1093/europace/euac062

Systematic monitoring for detection of atrial fibrillation in patients with acute ischaemic stroke (MonDAFIS): a randomised, open-label, multicentre study

Author(s): Karl Georg Haeusler, Paulus Kirchhof, Claudia Kunze, Serdar Tütüncü, Cornelia Fiessler, Carolin Malsch, Manuel C Olma, Muhammad Jawad-Ul-Qamar, Michael Krämer, Rolf Wachter, Dominik Michalski, Andrea Kraft, Timolaos Rizos, Klaus Gröschel, Götz Thomalla, Darius G Nabavi, Joachim Röther, Ulrich Laufs, Roland Veltkamp, Peter U Heuschmann, Matthias Endres, Michael Bauerle, Michael Besselmann, T
Published in: The Lancet Neurology, Issue 20/6, 2021, Page(s) 426-436, ISSN 1474-4422
Publisher: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(21)00067-3

Chronic kidney disease and risk of atrial fibrillation and heart failure in general population-based cohorts: the BiomarCaRE project

Author(s): Rehm M, Rothenbacher D, Iacoviello L, Costanzo S, Tunstall-Pedoe H, Fitton CA, Söderberg S, Hultdin J, Salomaa V, Jousilahti P, Palosaari T, Kuulasmaa K, Waldeyer C, Schnabel RB, Zeller T, Blankenberg S, Koenig W; BiomarCaRE Consortium
Published in: ESC Heart Fail., 2022, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1002/ehf2.13699

Expert opinion paper on cardiac imaging after ischemic stroke

Author(s): Renate B. Schnabel, Stephan Camen, Fabian Knebel, Andreas Hagendorff, Udo Bavendiek, Michael Böhm, Wolfram Doehner, Matthias Endres, Klaus Gröschel, Andreas Goette, Hagen B. Huttner, Christoph Jensen, Paulus Kirchhof, Grigorios Korosoglou, Ulrich Laufs, Jan Liman, Caroline Morbach, Darius Günther Nabavi, Tobias Neumann-Haefelin, Waltraud Pfeilschifter, Sven Poli, Timolaos Rizos, Andreas Rolf, J
Published in: Clinical Research in Cardiology, Issue 110/7, 2021, Page(s) 938-958, ISSN 1861-0684
Publisher: Steinkopff
DOI: 10.1007/s00392-021-01834-x

Mobile health for walking on the tightrope of optimal physical activity to reduce the risk of atrial fibrillation

Author(s): Renate B Schnabel, Larissa Fabritz, Paulus Kirchhof
Published in: European Heart Journal, Issue 42/25, 2021, Page(s) 2484-2486, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehab243

World Heart Federation Roadmap on Atrial Fibrillation – A 2020 Update

Author(s): Ben Freedman, Gerhard Hindricks, Amitava Banerjee, Adrian Baranchuk, Chi Keong Ching, Xin Du, Donna Fitzsimons, Jeff S. Healey, Takanori Ikeda, Trudie C. A. Lobban, Amam Mbakwem, Calambur Narasimhan, Lis Neubeck, Peter Noseworthy, Daniel M. Philbin, Fausto J. Pinto, Joselyn Rwebembera, Renate B. Schnabel, Jesper Hastrup Svendsen, Luis Aguinaga, Elena Arbelo, Michael Böhm, Hasan Ali Farhan, F. D.
Published in: Global Heart, Issue 16/1, 2021, ISSN 2211-8179
Publisher: Global Heart
DOI: 10.5334/gh.1023

Alcohol and atrial fibrillation: dose matters, not so much the type

Author(s): Dora Csengeri, Ngoc-Anh Sprünker, Renate B Schnabel
Published in: European Heart Journal, Issue 42/25, 2021, Page(s) 2507-2508, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehab180

Dynamic risk assessment to improve quality of care in patients with atrial fibrillation: the 7th AFNET/EHRA Consensus Conference

Author(s): Larissa Fabritz, Harry J G M Crijns, Eduard Guasch, Andreas Goette, Karl Georg Häusler, Dipak Kotecha, Thorsten Lewalter, Christian Meyer, Tatjana S Potpara, Michiel Rienstra, Renate B Schnabel, Stephan Willems, Guenter Breithardt, A John Camm, Anthony Chan, Winnie Chua, Mirko de Melis, Christina Dimopoulou, Dobromir Dobrev, Christina Easter, Lars Eckardt, Doreen Haase, Stephane Hatem, Jeff S Hea
Published in: EP Europace, 2021, ISSN 1099-5129
Publisher: Oxford University Press
DOI: 10.1093/europace/euaa279

Research Priorities in Atrial Fibrillation Screening

Author(s): Emelia J. Benjamin, Alan S. Go, Patrice Desvigne-Nickens, Christopher D. Anderson, Barbara Casadei, Lin Y. Chen, Harry J.G.M. Crijns, Ben Freedman, Mellanie True Hills, Jeff S. Healey, Hooman Kamel, Dong-Yun Kim, Mark S. Link, Renato D. Lopes, Steven A. Lubitz, David D. McManus, Peter A. Noseworthy, Marco V. Perez, Jonathan P. Piccini, Renate B. Schnabel, Daniel E. Singer, Robert G. Tieleman, Mint
Published in: Circulation, Issue 143/4, 2021, Page(s) 372-388, ISSN 0009-7322
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.120.047633

P-wave signal-averaged electrocardiography: Reference values, clinical correlates, and heritability in the Framingham Heart Study

Author(s): Jelena Kornej, Jared W Magnani, Sarah R Preis, Elsayed Z Soliman, Ludovic Trinquart, Darae Ko, Emelia J Benjamin, Honghuang Lin
Published in: Heart Rhythm, 2021, ISSN 1547-5271
Publisher: Elsevier BV
DOI: 10.1016/j.hrthm.2021.05.009

New biomarkers from multiomics approaches: improving risk prediction of atrial fibrillation

Author(s): Jelena Kornej, Vanessa A Hanger, Ludovic Trinquart, Darae Ko, Sarah R Preis, Emelia J Benjamin, Honghuang Lin
Published in: Cardiovasc Res, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvab073

Progression of stroke risk in atrial fibrillation: cohort study in general practice

Author(s): Sílvia C Mendonça, Duncan Edwards, Jenny Lund, Catherine Saunders and Jonathan Mant
Published in: British Journal of General Practice, 2023, ISSN 0960-1643
Publisher: Royal College of General Practitioners
DOI: 10.3399/bjgp.2022.0568

Heart and brain interactions

Author(s): Renate B. Schnabel, Gert Hasenfuß, Sylvia Buchmann, Kai G. Kahl, Stefanie Aeschbacher, Stefan Osswald, Christiane E. Angermann
Published in: Herz, 2020, ISSN 0340-9937
Publisher: Urban und Vogel Medien und Medizin Verlagsgesellschaft mbH
DOI: 10.1007/s00059-021-05022-5

Associations of the vasoactive peptides CT-proET-1 and MR-proADM with incident type 2 diabetes: results from the BiomarCaRE Consortium

Author(s): Sujana C, Salomaa V, Kee F, Seissler J, Jousilahti P, Neville C, Then C, Koenig W, Kuulasmaa K, Reinikainen J, Blankenberg S, Zeller T, Herder C, Mansmann U, Peters A, Thorand B; BiomarCaRE Consortium.
Published in: Cardiovascular Diabetology, 2022, ISSN 1475-2840
Publisher: BioMed Central
DOI: 10.1186/s12933-022-01513-9

Comparison of Cardiovascular Risk Factors in European Population Cohorts for Predicting Atrial Fibrillation and Heart Failure, Their Subsequent Onset, and Death

Author(s): Benedikt Schrage, Bastiaan Geelhoed, Teemu J. Niiranen, Francesco Gianfagna, Julie K. K. Vishram‐Nielsen, Simona Costanzo, Stefan Söderberg, Francisco M. Ojeda, Erkki Vartiainen, Maria Benedetta Donati, Christina Magnussen, Augusto Di Castelnuovo, Stephan Camen, Jukka Kontto, Wolfgang Koenig, Stefan Blankenberg, Giovanni de Gaetano, Allan Linneberg, Torben Jørgensen, Tanja Zeller, Kari Kuulasm
Published in: Journal of the American Heart Association, Issue 9/9, 2020, ISSN 2047-9980
Publisher: Wiley-Blackwell
DOI: 10.1161/jaha.119.015218

Gut microbiome and atrial fibrillation – results from a large population-based study

Author(s): Joonatan Palmu, Christin S. Börschel, Alfredo Ortega-Alonso, Lajos Markó, Mike Inouye, Pekka Jousilahti, Rodolfo A. Salido, Karenina Sanders, Caitriona Brennan, Gregory C Humphrey, Jon G Sanders, Friederike Gutmann, Dominik Linz, Veikko Salomaa, Aki S. Havulinna, Sofia K. Forslund, Rob Knight, Leo Lahti, Teemu Niiranen, Renate B. Schnabel
Published in: eBioMedicine, 2023, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2023.104583

Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes

Author(s): Dora Csengeri, Ngoc-Anh Sprünker, Augusto Di Castelnuovo, Teemu Niiranen, Julie Kk Vishram-Nielsen, Simona Costanzo, Stefan Söderberg, Steen M Jensen, Erkki Vartiainen, Maria Benedetta Donati, Christina Magnussen, Stephan Camen, Francesco Gianfagna, Maja-Lisa Løchen, Frank Kee, Jukka Kontto, Ellisiv B Mathiesen, Wolfgang Koenig, Blankenberg Stefan, Giovanni de Gaetano, Torben Jørgensen, Kari K
Published in: European Heart Journal, 2021, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehaa953

AN ARTIFICIAL INTELLIGENCE-BASED MODEL FOR PREDICTION OF ATRIAL FIBRILLATION FROM SINGLE-LEAD SINUS RHYTHM ECGS ENABLING SCREENING

Author(s): Fredrik Viberg, Tove Hygrell, Erik Dahlberg, Peter Charlton, Katrin Kemp Gudmundsdottir, Jonathan Mant, Josef Lindman Hornlund, Emma Svennberg
Published in: Heart Rhythm Society, 2021, ISSN 1547-5271
Publisher: Elsevier B.V.
DOI: 10.1016/j.hrthm.2021.06.1150

Disease awareness and knowledge of stroke- and atrial fibrillation risk factors in cardiovascular patients

Author(s): D Engler, L Bauer, J Brederecke, A Ohlrogge, S Camen, C S Boerschel, S Blankenberg, R B Schnabel
Published in: Europace, 2023, ISSN 1532-2092
Publisher: Oxford University Press
DOI: 10.1093/europace/euad122.032

Prioritising Electrocardiograms for Manual Review to Improve the Efficiency of Atrial Fibrillation Screening

Author(s): Mary Adeniji, James Brimicombe, Martin R Cowie, Andrew Dymond, Hannah Clair Linden, Gregory Y H Lip, Jonathan Mant, Madhumitha Pandiaraja, Kate Williams, Peter H Charlton
Published in: Annu Int Conf IEEE Eng Med Biol Soc, 2022
Publisher: United States
DOI: 10.1109/embc48229.2022.9871092

Electrocardiographic markers of subclinical atrial fibrillation detected by implantable loop recorder

Author(s): LY Xing, SZ Diederichsen, S Hojberg, DW Krieger, C Graff, MS Olesen, JB Nielsen, A Brandes, L Kober, KJ Haugan, JH Svendsen
Published in: europace, 2023, ISSN 1532-2092
Publisher: Oxford University Press
DOI: 10.1093/europace/euad122.616

Atrial fibrillation screening to prevent stroke in patients with high NT-proBNP-a post-hoc analysis of the randomized LOOP study

Author(s): SZ Diederichsen, LY Xing, KJ Haugan, S Hoejberg, D Krieger, A Brandes, L Koeber, R Frikke-Schmidt, JH Svendsen
Published in: 2023, ISSN 1532-2092
Publisher: Oxford University Press
DOI: 10.1093/europace/euad122.061

The association between social network index, atrial fibrillation, and mortality in the Framingham Heart Study.

Author(s): Jelena Kornej, Darae Ko, Honghuang Lin, Joanne M Murabito, Emelia J Benjamin, Ludovic Trinquart, Sarah R Preis
Published in: Scientific Reports, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-07850-9

Rationale kardiale Diagnostik nach ischämischem Schlaganfall oder TIA

Author(s): Renate B. Schnabel, Karl Georg Häusler
Published in: DMW - Deutsche Medizinische Wochenschrift, Issue 146/12, 2021, Page(s) 801-808, ISSN 0012-0472
Publisher: Georg Thieme Verlag
DOI: 10.1055/a-1221-7095

Tissue-specific multiOMICs analysis of atrial fibrillation

Author(s): Ines Assum, Julia Krause, Markus O. Scheinhardt, Christian Müller, Elke Hammer, Christin S. Börschel, Uwe Völker, Lenard Conradi, Bastiaan Geelhoed, Tanja Zeller, Renate B. Schnabel, Matthias Heinig
Published in: 2021
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2020.04.06.021527

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