Immune profiling to guide host-directed interventions to cure HBV infections

Información del proyecto

IP-cure-B

Identificador del acuerdo de subvención: 847939

DOI

10.3030/847939

Proyecto cerrado

Fecha de la firma de la CE 5 Diciembre 2019

Fecha de inicio 1 Enero 2020

Fecha de finalización 31 Diciembre 2025

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total

€ 10 343 030,50

Aportación de la UE

€ 9 983 029,00

Coordinado por

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

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Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (1)

Public website

Public website online

Publicaciones

Peer reviewed articles (24)

HBV-driven host chromatin accessibility changes affect liver metabolic pathways, iron homeostasis and promote a preneoplastic phenotype

Autores: Vincenzo Alfano, Giuseppe Rubens Pascucci, Giacomo Corleone, Massimiliano Cocca, Francesca De Nicola, Océane Floriot, Alexia Paturel, Francesca Casuscelli Di Tocco, Claude Caron de Fromentel, Philippe Merle, Michel Rivoire, Massimo Levrero, Francesca Guerrieri
Publicado en: Journal of Experimental & Clinical Cancer Research, Edición 44, 2025, ISSN 1756-9966
Editor: Springer Science and Business Media LLC
DOI: 10.1186/s13046-025-03414-7

Refining the DC-targeting vaccination for preventing emerging infectious diseases

Autores: Pastor Y, Ghazzaui N, Hammoudi A, Centlivre M, Cardinaud S, Levy Y
Publicado en: Frontiers in Immunology, 2022, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2022.949779

The scientific basis of combination therapy for chronic hepatitis B functional cure.

Autores: Seng Gee Lim, Thomas F Baumert,Carolina Boni, Ed Gane, Massimo Levrero, Anna S Lok, Mala K Maini, Norah A Terrault, Fabien Zoulim.
Publicado en: Nature Reviews Gastroenterology & Hepatology, 2023, ISSN 1759-5053
Editor: Nature Publications Group
DOI: 10.1038/s41575-022-00724-5

Eliminating cccDNA to cure hepatitis B virus infection.

Autores: Fabien Zoulim and Barbara Testoni
Publicado en: Journal of Hepatology - EASL, Edición Vol 1-4, 2023, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2023.01.017

Early intrahepatic recurrence of HBV infection in liver transplant recipients despite antiviral prophylaxis.

Autores: François Villeret, Fanny Lebossé, Sylvie Radenne, Didier Samuel Bruno Roche, Jean-Yves Mabrut, Vincent Leroy, Georges-Philippe Pageaux, Rodolphe Anty, Sylvie Thevenon, Sinafa Si Ahmed, Aaron Hamilton, Marintha Heil, Caroline Scholtès, Massimo Levrero, Barbara Testoni, Fabien Zoulim.
Publicado en: JHEP Reports, 2023, ISSN 2589-5559
Editor: Elsevier
DOI: 10.1016/j.jhepr.2023.100728

The lncRNAs in HBV-Related HCCs: Targeting Chromatin Dynamics and Beyond.

Autores: Vincenzo Alfano; Mirjam B. Zeisel; Massimo Levrero; Francesca Guerrieri
Publicado en: Cancers, Vol 13, Iss 3115, p 3115 (2021), Edición 1, 2021, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13133115

HBV and HBsAg strongly reshape the phenotype, function, and metabolism of DCs according to patients’ clinical stage

Autores: Lucile Dumolard, Theophile Gerster, Florent Chuffart, Thomas Decaens, Marie-Noelle Hilleret, Sylvie Larrat, Philippe Saas, Evelyne Jouvin-Marche, David Durantel, Patrice N. Marche, Zuzana Macek Jilkova, Caroline Aspord
Publicado en: Hepatology Communications, Edición 9, 2025, ISSN 2471-254X
Editor: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/hc9.0000000000000625

Immune checkpoints on T and NK cells in the context of HBV infection: Landscape, pathophysiology and therapeutic exploitation

Autores: Lucile Dumolard; Caroline Aspord; Caroline Aspord; Patrice N. Marche; Zuzana Macek Jilkova; Zuzana Macek Jilkova
Publicado en: Frontiers in Immunology, Edición Vol 14, 2023, ISSN 1664-3224
Editor: Frontiers Media S.A.
DOI: 10.3389/fimmu.2023.1148111

Opportunities and challenges for hepatitis B cure

Autores: Armando Andres Roca Suarez; Fabien Zoulim
Publicado en: Gastroenterology, Edición 8, 2023, ISSN 0016-5085
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1136/egastro-2023-100021

Differences in the intrahepatic expression of immune checkpoint molecules on T cells and natural killer cells in chronic HBV patients

Autores: Lucile Dumolard, Marie-Noelle Hilleret, Charlotte Costentin, Marion Mercey-Ressejac, Nathalie Sturm, Theophile Gerster, Thomas Decaens, Evelyne Jouvin-Marche, Patrice N. Marche, Zuzana Macek Jilkova
Publicado en: Frontiers in Immunology, Edición 15, 2025, ISSN 1664-3224
Editor: Frontiers Media SA
DOI: 10.3389/fimmu.2024.1489770

Long-term quantitative hepatitis B surface antigen (HBsAg) trajectories in persons with and without HBsAg loss on tenofovir-containing antiretroviral therapy.

Autores: Begré L, Boyd A, Salazar-Vizcaya L, Suter-Riniker F, Béguelin C, Rockstroh JK, Günthard HF, Calmy A, Cavassini M, Stöckle M, Schmid P, Bernasconi E, Levrero M, Zoulim F, Wandeler G, Rauch A;
Publicado en: HIV Medicine, 2024, Página(s) 291-298, ISSN 1464-2662
Editor: Blackwell Publishing Inc.
DOI: 10.1111/hiv.13561

Protocol for isolating CD163+ Kupffer cells from human liver resections

Autores: Armando Andres Roca Suarez, Marie-Laure Plissonnier, Maud Michelet, Anaëlle Dubois, Sarah Heintz, Maria Saez-Palma, Marion Delphin, Isabelle Bordes, Jennifer Molle, Audrey Diederichs, Mélanie Rodà, Emmanuel Combe, Léa Mougené, Guillaume Giraud, Xavier Grand, Michel Rivoire, Massimo Levrero, Barbara Testoni, Fabien Zoulim
Publicado en: STAR Protocols, Edición 5, 2025, Página(s) 103359, ISSN 2666-1667
Editor: Elsevier BV
DOI: 10.1016/j.xpro.2024.103359

Circulating HBV RNA and hepatitis B core-related antigen trajectories in persons with HIV/HBV coinfection and HBsAg loss on tenofovir therapy.

Autores: Begré L, Boyd A, Plissonnier ML, Testoni B, Salazar-Vizcaya L, Suter-Riniker F, Scholtès C, Béguelin C, Rockstroh JK, Günthard HF, Calmy A, Cavassini M, Hirsch HH, Schmid P, Bernasconi E, Levrero M, Wandeler G, Zoulim F, Rauch A/
Publicado en: The Journal of Infectious Diseases, 2024, ISSN 1537-6613
Editor: Oxford University Press
DOI: 10.1093/infdis/jiae189

A human immune system (HIS) mouse model that dissociates roles for mouse and human FcR+ cells during antibody-mediated immune responses.

Autores: Thaller, A.L., Jönsson, F., Fiquet, O., Marie, S., Doisne, J.-M., Girelli-Zubani, G., Eri, T., Fernandes, P., Tatirovsky, E., Langa-Vives, F., Bruhns, P., Strick-Marchand, H. and Di Santo, J.P.
Publicado en: European Journal of Immunology, Edición 53: 2350454., 2023, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202350454

Protein tyrosine phosphatase delta is a STAT3-phosphatase and suppressor of metabolic liver disease

Autores: Armando Andres Roca Suarez, Frank Jühling, Julien Moehlin, Laurent Mailly, Alessia Virzì, Nicolas Brignon, Sarah C Durand, Marine A Oudot, Eugenie Schaeffer, Romain Martin, Laura Meiss-Heydmann, Charlotte Bach, Zakaria Boulahtouf, Lea Girard, Emma Osswald, Carole Jamey, Daniel Brumaru, Nassim Dali-Youcef, Atish Mukherji, Maria Saez-Palma, Barbara Testoni, Fabien Zoulim, Bhuvaneswari Koneru, Naot
Publicado en: eGastroenterology, Edición 3, 2025, Página(s) e100159, ISSN 2766-0125
Editor: BMJ
DOI: 10.1136/egastro-2024-100159

OS-091 Precision-cut liver slices as a pre-clinical model for the evaluation of host-targeting agents against hepatitis B virus and hepatitis delta virus infection

Autores: Maud Michelet, Armando Andres Roca Suarez, Anaëlle Dubois, Sarah Heintz, Marie-Laure Plissonnier, Maria Saez-Palma, Simon Fletcher, Michel Rivoire, Sandra Phillips, Elena Palma, Shilpa Chokshi, Barbara Testoni, Fabien Zoulim
Publicado en: Journal of Hepatology, Edición 80, 2024, Página(s) S58, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/s0168-8278(24)00532-4

Functional immune responses induced by a capsid assembly modulator in chronic hepatitis B virus-infected humanized mice

Autores: Priyanka Fernandes, Yidan Wang, Jean-Marc Doisne, Anna Thaller, Oriane Fiquet, Rémy Dailleux, Franck Amblard, Barbara Testoni, Yada Aronthippaitoon, Hugo Mouquet, Camille Sureau, Bastien Reyné, Camilla Tiezzi, Patrick Soussan, Massimo Levrero, Fabien Zoulim, Raymond F. Schinazi, Helene Strick-Marchand
Publicado en: Cell Host & Microbe, Edición 34, 2026, Página(s) 116-130.e7, ISSN 1931-3128
Editor: Cell Press
DOI: 10.1016/j.chom.2025.12.001

Evaluation of the HBV liver reservoir with fine needle aspirates.

Autores: Barbara Testoni , Armando Andres Roca Suarez , Arianna Battisti, Marie-Laure Plissonnier, Marintha Heil, Thierry Fontanges, François Villeret, Yasmina Chouik, Massimo Levrero, Upkar Gill, Patrick Kennedy, Fabien Zoulim.
Publicado en: JHEP reports, Edición Vol. 5, 2023, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhepr.2023.100841

Cytosine base editing inhibits hepatitis B virus replication and reduces HBsAg expression in vitro and in vivo

Autores: Elena M. Smekalova; Maria G. Martinez; Emmanuel Combe; Anuj Kumar; Selam Dejene; Dominique Leboeuf; Chao-Ying Chen; J. Robert Dorkin; Lan Shuan Shuang; Sarah Kieft; Lauren Young; Luis Alberto Barrera; Michael S. Packer; Giuseppe Ciaramella; Barbara Testoni; Francine Gregoire; Fabien Zoulim
Publicado en: Molecular Therapy: Nucleic Acids, Edición Vol. 35, 2024, ISSN 1525-0016
Editor: Nature Publishing Group
DOI: 10.1016/j.omtn.2023.102112

New Perspectives on Development of Curative Strategies for Chronic Hepatitis B

Autores: Jordan J. Feld; Anna S. Lok; Fabien Zoulim
Publicado en: Clinical Gastroenterology and Hepatology, 2023, ISSN 1542-3565
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.cgh.2023.02.032

G-quadruplexes control hepatitis B virus replication by promoting cccDNA transcription and phase separation in hepatocytes.

Autores: Guillaume Giraud, Mélanie Rodà, Pélagie Huchon, Maud Michelet, Sarah Maadadi, Daniel Jutzi, Roland Montserret, Marc-David Ruepp, Romain Parent, Christophe Combet, Fabien Zoulim, Barbara Testoni.
Publicado en: Nucleic Acids Research, 2024, ISSN 1362-4962
Editor: Oxford University Press
DOI: 10.1093/nar/gkad1200

TLR8 agonist selgantolimod regulates Kupffer cell differentiation status and impairs HBV entry into hepatocytes via an IL-6-dependent mechanism.

Autores: Armando Andres Roca Suarez, Marie-Laure Plissonnier, Xavier Grand, Maud Michelet, Guillaume Giraud, Maria Saez-Palma, Anaëlle Dubois, Sarah Heintz, Audrey Diederichs, Nicolaas Van Renne, Thomas Vanwolleghem, Stephane Daffis, Li Li, Abigail Fosdick, Nikita Kolhatkar, Yao-Chun Hsu, Jeffrey J. Wallin, Audrey Lau, Simon P. Fletcher, Michel Rivoire, Massimo Levrero, Barbara Testoni, Fabien Zoulim.
Publicado en: GUT, 2024, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2023-331396

Quantification of circulating HBV RNA expressed from intrahepatic cccDNA in untreated and NUC treated patients with chronic hepatitis B

Autores: Barbara Testoni; Caroline Scholtès; Marie-Laure Plissonnier; Alexia Paturel; Françoise Berby; Floriana Facchetti; François Villeret; Elisabetta Degasperi; Beth Scott; Aaron Hamilton; Marintha Heil; Pietro Lampertico; Massimo Levrero; Fabien Zoulim
Publicado en: GUT, Edición 8, 2023, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2023-330644

Hepatitis B Virus Targets Lipid Transport Pathways to Infect Hepatocytes

Autores: Knud Esser; Xiaoming Cheng; Jochen M. Wettengel; Julie Lucifora; Lea Hansen-Palmus; Katharina Austen; Armando A. Roca Suarez; Sarah Heintz; Barbara Testoni; Firat Nebioglu; Minh Tu Pham; Shangqing Yang; Alma Zernecke; Dirk Wohlleber; Marc Ringelhan; Mathias Broxtermann; Daniel Hartmann; Norbert Hüser; Julia Mergner; Andreas Pichlmair; Wolfgang E. Thasler; Mathias Heikenwalder; Georg Gasteiger; An
Publicado en: Cellular and Molecular Gastroenterology and Hepatology, Edición Vol. 16 Iss 2, 2023, ISSN 2352-345X
Editor: Elsevier Inc.
DOI: 10.1016/j.jcmgh.2023.03.011

Conference proceedings (1)

HBV 2021: New therapeutic strategies against an old foe

Autores: Armando Andres Roca Suarez, Barbara Testoni, Fabien Zoulim
Publicado en: Liver International, Edición vol 41, 2021
Editor: WILEY
DOI: 10.1111/liv.14851

Non-peer reviewed articles (1)

Precision-cut liver slices as a model for the evaluation of host-targeting agents against hepatitis B and delta viruses

Autores: Armando Andres Roca Suarez, Maud Michelet, Anaëlle Dubois, Audrey Diederichs, Marie-Laure Plissonnier, Sarah Heintz, Maria Saez-Palma, Simon P. Fletcher, Michel Rivoire, Sandra Phillips, Elena Palma, Shilpa Chokshi, Fabien Zoulim, Barbara Testoni
Publicado en: BioRxiv, 2025, ISSN 2692-8205
Editor: openRxiv
DOI: 10.64898/2025.12.06.692712