Immune profiling to guide host-directed interventions to cure HBV infections

Información del proyecto

IP-cure-B

Identificador del acuerdo de subvención: 847939

DOI

10.3030/847939

Fecha de la firma de la CE 5 Diciembre 2019

Fecha de inicio 1 Enero 2020

Fecha de finalización 31 Diciembre 2025

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total

€ 10 343 030,50

Aportación de la UE

€ 9 983 029,00

Coordinado por

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (1)

Public website

Public website online

Publicaciones

Peer reviewed articles (17)

Refining the DC-targeting vaccination for preventing emerging infectious diseases

Autores: Pastor Y, Ghazzaui N, Hammoudi A, Centlivre M, Cardinaud S, Levy Y
Publicado en: Frontiers in Immunology, 2022, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2022.949779

The scientific basis of combination therapy for chronic hepatitis B functional cure.

Autores: Seng Gee Lim, Thomas F Baumert,Carolina Boni, Ed Gane, Massimo Levrero, Anna S Lok, Mala K Maini, Norah A Terrault, Fabien Zoulim.
Publicado en: Nature Reviews Gastroenterology & Hepatology, 2023, ISSN 1759-5053
Editor: Nature Publications Group
DOI: 10.1038/s41575-022-00724-5

Eliminating cccDNA to cure hepatitis B virus infection.

Autores: Fabien Zoulim and Barbara Testoni
Publicado en: Journal of Hepatology - EASL, Edición Vol 1-4, 2023, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2023.01.017

Early intrahepatic recurrence of HBV infection in liver transplant recipients despite antiviral prophylaxis.

Autores: François Villeret, Fanny Lebossé, Sylvie Radenne, Didier Samuel Bruno Roche, Jean-Yves Mabrut, Vincent Leroy, Georges-Philippe Pageaux, Rodolphe Anty, Sylvie Thevenon, Sinafa Si Ahmed, Aaron Hamilton, Marintha Heil, Caroline Scholtès, Massimo Levrero, Barbara Testoni, Fabien Zoulim.
Publicado en: JHEP Reports, 2023, ISSN 2589-5559
Editor: Elsevier
DOI: 10.1016/j.jhepr.2023.100728

The lncRNAs in HBV-Related HCCs: Targeting Chromatin Dynamics and Beyond.

Autores: Vincenzo Alfano; Mirjam B. Zeisel; Massimo Levrero; Francesca Guerrieri
Publicado en: Cancers, Vol 13, Iss 3115, p 3115 (2021), Edición 1, 2021, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13133115

Immune checkpoints on T and NK cells in the context of HBV infection: Landscape, pathophysiology and therapeutic exploitation

Autores: Lucile Dumolard; Caroline Aspord; Caroline Aspord; Patrice N. Marche; Zuzana Macek Jilkova; Zuzana Macek Jilkova
Publicado en: Frontiers in Immunology, Edición Vol 14, 2023, ISSN 1664-3224
Editor: Frontiers Media S.A.
DOI: 10.3389/fimmu.2023.1148111

Opportunities and challenges for hepatitis B cure

Autores: Armando Andres Roca Suarez; Fabien Zoulim
Publicado en: Gastroenterology, Edición 8, 2023, ISSN 0016-5085
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1136/egastro-2023-100021

Long-term quantitative hepatitis B surface antigen (HBsAg) trajectories in persons with and without HBsAg loss on tenofovir-containing antiretroviral therapy.

Autores: Begré L, Boyd A, Salazar-Vizcaya L, Suter-Riniker F, Béguelin C, Rockstroh JK, Günthard HF, Calmy A, Cavassini M, Stöckle M, Schmid P, Bernasconi E, Levrero M, Zoulim F, Wandeler G, Rauch A;
Publicado en: HIV Medicine, 2024, Página(s) 291-298, ISSN 1464-2662
Editor: Blackwell Publishing Inc.
DOI: 10.1111/hiv.13561

Circulating HBV RNA and hepatitis B core-related antigen trajectories in persons with HIV/HBV coinfection and HBsAg loss on tenofovir therapy.

Autores: Begré L, Boyd A, Plissonnier ML, Testoni B, Salazar-Vizcaya L, Suter-Riniker F, Scholtès C, Béguelin C, Rockstroh JK, Günthard HF, Calmy A, Cavassini M, Hirsch HH, Schmid P, Bernasconi E, Levrero M, Wandeler G, Zoulim F, Rauch A/
Publicado en: The Journal of Infectious Diseases, 2024, ISSN 1537-6613
Editor: Oxford University Press
DOI: 10.1093/infdis/jiae189

A human immune system (HIS) mouse model that dissociates roles for mouse and human FcR+ cells during antibody-mediated immune responses.

Autores: Thaller, A.L., Jönsson, F., Fiquet, O., Marie, S., Doisne, J.-M., Girelli-Zubani, G., Eri, T., Fernandes, P., Tatirovsky, E., Langa-Vives, F., Bruhns, P., Strick-Marchand, H. and Di Santo, J.P.
Publicado en: European Journal of Immunology, Edición 53: 2350454., 2023, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202350454

Evaluation of the HBV liver reservoir with fine needle aspirates.

Autores: Barbara Testoni , Armando Andres Roca Suarez , Arianna Battisti, Marie-Laure Plissonnier, Marintha Heil, Thierry Fontanges, François Villeret, Yasmina Chouik, Massimo Levrero, Upkar Gill, Patrick Kennedy, Fabien Zoulim.
Publicado en: JHEP reports, Edición Vol. 5, 2023, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhepr.2023.100841

Cytosine base editing inhibits hepatitis B virus replication and reduces HBsAg expression in vitro and in vivo

Autores: Elena M. Smekalova; Maria G. Martinez; Emmanuel Combe; Anuj Kumar; Selam Dejene; Dominique Leboeuf; Chao-Ying Chen; J. Robert Dorkin; Lan Shuan Shuang; Sarah Kieft; Lauren Young; Luis Alberto Barrera; Michael S. Packer; Giuseppe Ciaramella; Barbara Testoni; Francine Gregoire; Fabien Zoulim
Publicado en: Molecular Therapy: Nucleic Acids, Edición Vol. 35, 2024, ISSN 1525-0016
Editor: Nature Publishing Group
DOI: 10.1016/j.omtn.2023.102112

New Perspectives on Development of Curative Strategies for Chronic Hepatitis B

Autores: Jordan J. Feld; Anna S. Lok; Fabien Zoulim
Publicado en: Clinical Gastroenterology and Hepatology, 2023, ISSN 1542-3565
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.cgh.2023.02.032

G-quadruplexes control hepatitis B virus replication by promoting cccDNA transcription and phase separation in hepatocytes.

Autores: Guillaume Giraud, Mélanie Rodà, Pélagie Huchon, Maud Michelet, Sarah Maadadi, Daniel Jutzi, Roland Montserret, Marc-David Ruepp, Romain Parent, Christophe Combet, Fabien Zoulim, Barbara Testoni.
Publicado en: Nucleic Acids Research, 2024, ISSN 1362-4962
Editor: Oxford University Press
DOI: 10.1093/nar/gkad1200

TLR8 agonist selgantolimod regulates Kupffer cell differentiation status and impairs HBV entry into hepatocytes via an IL-6-dependent mechanism.

Autores: Armando Andres Roca Suarez, Marie-Laure Plissonnier, Xavier Grand, Maud Michelet, Guillaume Giraud, Maria Saez-Palma, Anaëlle Dubois, Sarah Heintz, Audrey Diederichs, Nicolaas Van Renne, Thomas Vanwolleghem, Stephane Daffis, Li Li, Abigail Fosdick, Nikita Kolhatkar, Yao-Chun Hsu, Jeffrey J. Wallin, Audrey Lau, Simon P. Fletcher, Michel Rivoire, Massimo Levrero, Barbara Testoni, Fabien Zoulim.
Publicado en: GUT, 2024, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2023-331396

Quantification of circulating HBV RNA expressed from intrahepatic cccDNA in untreated and NUC treated patients with chronic hepatitis B

Autores: Barbara Testoni; Caroline Scholtès; Marie-Laure Plissonnier; Alexia Paturel; Françoise Berby; Floriana Facchetti; François Villeret; Elisabetta Degasperi; Beth Scott; Aaron Hamilton; Marintha Heil; Pietro Lampertico; Massimo Levrero; Fabien Zoulim
Publicado en: GUT, Edición 8, 2023, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2023-330644

Hepatitis B Virus Targets Lipid Transport Pathways to Infect Hepatocytes

Autores: Knud Esser; Xiaoming Cheng; Jochen M. Wettengel; Julie Lucifora; Lea Hansen-Palmus; Katharina Austen; Armando A. Roca Suarez; Sarah Heintz; Barbara Testoni; Firat Nebioglu; Minh Tu Pham; Shangqing Yang; Alma Zernecke; Dirk Wohlleber; Marc Ringelhan; Mathias Broxtermann; Daniel Hartmann; Norbert Hüser; Julia Mergner; Andreas Pichlmair; Wolfgang E. Thasler; Mathias Heikenwalder; Georg Gasteiger; An
Publicado en: Cellular and Molecular Gastroenterology and Hepatology, Edición Vol. 16 Iss 2, 2023, ISSN 2352-345X
Editor: Elsevier Inc.
DOI: 10.1016/j.jcmgh.2023.03.011

Conference proceedings (1)

HBV 2021: New therapeutic strategies against an old foe

Autores: Armando Andres Roca Suarez, Barbara Testoni, Fabien Zoulim
Publicado en: Liver International, Edición vol 41, 2021
Editor: WILEY
DOI: 10.1111/liv.14851