Improved Vaccination Strategies for Older Adults

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Communication report

This deliverable consists of a report listing all ISOLDA communications publications presentations press releases newsletters etc and will be prepared and updated at M16 M32 M46 and M60

Ethics report first reporting period

This deliverable consists of the periodic report by the Ethics Advisory Board for M1M16

Ethics report third reporting period

This deliverable consists of the periodic report by the Ethics Advisory Board for M33-M46.

Composition of the Scientific and Ethics Advisory Boards

This deliverable consists of a report listing the members of the SAB and EAB, as well as their expertise, roles and responsibilities, including the identification of the Ethics Reviewer responsible for the compilation and preparation of the Ethics Reports D5.7-D5.10.

Ethics report second reporting period

This deliverable consists of the periodic report by the Ethics Advisory Board for M17M32

ISOLDA website

This deliverable consists of the online publishing of ISOLDA official website

Publications

Centenarians born before 1919 are resistant to COVID-19

Auteurs: Caruso et al.
Publié dans: Aging Clinical and Experimental Research, 2022, ISSN 1720-8319
Éditeur: Springer
DOI: 10.1007/s40520-022-02287-6

Interaction between SARS-CoV PBM and Cellular PDZ Domains Leading to Virus Virulence

Auteurs: Jose M. Honrubia, Jose R. Valverde, Diego Muñoz-Santos, Jorge Ripoll-Gómez, Nuria de la Blanca, Jorge Izquierdo, Marta Villarejo-Torres, Ana Marchena-Pasero, María Rueda-Huélamo, Ivan Nombela, Mercedes Ruiz-Yuste, Sonia Zuñiga, Isabel Sola, Luis Enjuanes
Publié dans: Viruses, Numéro 16, 2024, Page(s) 1214, ISSN 1999-4915
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v16081214

CAR-T Cells for the Treatment of Lung Cancer

Auteurs: Chocarro, Luisa, Hugo Arasanz, Leticia Fernández-Rubio, Ester Blanco, Miriam Echaide, Ana Bocanegra, Lucía Teijeira, Maider Garnica, Idoia Morilla, Maite Martínez-Aguillo, Sergio Piñeiro-Hermida, Pablo Ramos, Juan José Lasarte, Ruth Vera, Grazyna Kochan, and David Escors
Publié dans: Life, Numéro 20782489, 2022, Page(s) 561, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/life12040561

Avatar Mice Underscore the Role of the T Cell-Dendritic Cell Crosstalk in Ebola Virus Disease and Reveal Mechanisms of Protection in Survivors

Auteurs: Monika Rottstegge, Tom Tipton, Lisa Oestereich, Paula Ruibal, Emily V. Nelson, Catherine Olal, Julia R. Port, Johan Seibel, Elisa Pallasch, Sabrina Bockholt, Fara Raymond Koundouno, Joseph Akoi Boré, Estefanía Rodríguez, Beatriz Escudero-Pérez, Stephan Günther, Miles W. Carroll, César Muñoz-Fontela
Publié dans: Journal of Virology, Numéro 00219193, 2022, ISSN 0021-9193
Éditeur: American Society for Microbiology
DOI: 10.1128/jvi.00574-22

Cutting-Edge CAR Engineering: Beyond T Cells

Auteurs: L. Chocarro et al.
Publié dans: Biomedicines, 2022, ISSN 2227-9059
Éditeur: IDMP
DOI: 10.3390/biomedicines10123035

Understanding LAG-3 Signaling

Auteurs: Luisa Chocarro, Ester Blanco, Miren Zuazo, Hugo Arasanz, Ana Bocanegra, Leticia Fernández-Rubio, Pilar Morente, Gonzalo Fernández-Hinojal, Miriam Echaide, Maider Garnica, Pablo Ramos, Ruth Vera, Grazyna Kochan, David Escors
Publié dans: International Journal of Molecular Sciences, Numéro 22/10, 2021, Page(s) 5282, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22105282

Fractalkine in Health and Disease

Auteurs: Claudia Rodriguez, Luisa Chocarro, Miriam Echaide, Karina Ausin, David Escors, Grazyna Kochan
Publié dans: International Journal of Molecular Sciences, Numéro 25, 2025, Page(s) 8007, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25158007

PD-1/LAG-3 co-signaling profiling uncovers CBL ubiquitin ligases as key immunotherapy targets

Auteurs: Luisa Chocarro, Ester Blanco, Leticia Fernandez-Rubio, Maider Garnica, Miren Zuazo, Maria Jesus Garcia, Ana Bocanegra, Miriam Echaide, Colette Johnston, Carolyn J Edwards, James Legg, Andrew J Pierce, Hugo Arasanz, Gonzalo Fernandez-Hinojal, Ruth Vera, Karina Ausin, Enrique Santamaria, Joaquin Fernandez-Irigoyen, Grazyna Kochan, David Escors
Publié dans: EMBO Molecular Medicine, Numéro 16, 2024, Page(s) 1791-1816, ISSN 1757-4684
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/s44321-024-00098-y

How Can We Improve the Vaccination Response in Older People? Part II: Targeting Immunosenescence of Adaptive Immunity Cells

Auteurs: Garnica, Maider, Anna Aiello, Mattia Emanuela Ligotti, Giulia Accardi, Hugo Arasanz, Ana Bocanegra, Ester Blanco, Anna Calabrò, Luisa Chocarro, Miriam Echaide, Grazyna Kochan, Leticia Fernandez-Rubio, Pablo Ramos, Fanny Pojero, Nahid Zareian, Sergio Piñeiro-Hermida, Farzin Farzaneh, Giuseppina Candore, Calogero Caruso, and David Escors
Publié dans: International Journal of Molecular Sciences, Numéro 20782489, 2022, Page(s) 9797, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23179797

SARS-CoV-2-Mediated Lung Edema and Replication Are Diminished by Cystic Fibrosis Transmembrane Conductance Regulator Modulators

Auteurs: Jose M. Honrubia, et al.
Publié dans: mBio, 2023, ISSN 2150-7511
Éditeur: ASM
DOI: 10.1128/mbio.03136-22

FDA-Approved Inhibitors of RTK/Raf Signaling Potently Impair Multiple Steps of In Vitro and Ex Vivo Influenza A Virus Infections

Auteurs: Meineke, Robert, Sonja Stelz, Maximilian Busch, Christopher Werlein, Mark Kühnel, Danny Jonigk, Guus F. Rimmelzwaan, and Husni Elbahesh
Publié dans: Viruses, Numéro 20782489, 2022, Page(s) 2058, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v14092058

Comparison of two antibody screening systems for SARS-CoV-2 antibody detection in recovered and vaccinated subjects - test performance and possible indicators for immunity

Auteurs: Rebecca Jonczyk a, Nils Stanislawski b, Lisa K. Seiler a, Somayeh Ahani a, Arne Bueltemeier a, Frank Stahl a, Sascha Beutel a, Holger Blume b, Corinna Hauß c, Anette Melk d, Mira Paulsen d, Meike Stiesch e, Andreas Winkel e, Philipp-Cornelius Pott e, Giulietta Saletti f, Mariana González-Hernández f, Franziska Karola Kaiser f, Guus F. Rimmelzwaan f, Albert D.M.E. Osterhaus f, Cornelia Blume a
Publié dans: Journal of Clinical Virology, Numéro Volume 157, 2022, ISSN 1386-6532
Éditeur: Elsevier BV
DOI: 10.1016/j.jcv.2022.105322

Systemic CD4 Immunity and PD-L1/PD-1 Blockade Immunotherapy

Auteurs: David Escors, Ana Bocanegra, Luisa Chocarro, Ester Blanco, Sergio Piñeiro-Hermida, Maider Garnica, Leticia Fernandez-Rubio, Ruth Vera, Hugo Arasanz, Grazyna Kochan
Publié dans: International Journal of Molecular Sciences, Numéro 23, 2025, Page(s) 13241, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms232113241

Immune Profiling Uncovers Memory T-Cell Responses with a Th17 Signature in Cancer Patients with Previous SARS-CoV-2 Infection Followed by mRNA Vaccination

Auteurs: Miriam Echaide, Ibone Labiano, Marina Delgado, Angela Fernández de Lascoiti, Patricia Ochoa, Maider Garnica, Pablo Ramos, Luisa Chocarro, Leticia Fernández, Hugo Arasanz, Ana Bocanegra, Ester Blanco, Sergio Piñeiro-Hermida, Pilar Morente, Ruth Vera, Maria Alsina, David Escors, Grazyna Kochan
Publié dans: Cancers, Numéro 14, 2025, Page(s) 4464, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14184464

SARS-CoV-2 ORF8 accessory protein is a virulence factor

Auteurs: Bello-Perez et al.
Publié dans: Virology, 2023, ISSN 0042-6822
Éditeur: Academic Press
DOI: 10.1128/mbio.00451-23

Geroprotective applications of oleuropein and hydroxytyrosol through the hallmarks of ageing

Auteurs: Anna Calabrò, Anna Aiello, Paula Silva, Calogero Caruso, Giuseppina Candore, Giulia Accardi
Publié dans: GeroScience, 2025, ISSN 2509-2723
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/s11357-025-01697-4

Cell type dependent stability and virulence of a recombinant SARS-CoV-2, and engineering of a propagation deficient RNA replicon to analyze virus RNA synthesis

Auteurs: Li Wang et al.
Publié dans: Front. Cell. Infect. Microbiol., 2023, ISSN 2235-2988
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fcimb.2023.1268227

Aging and Options to Halt Declining Immunity to Virus Infections

Auteurs: Miguel Ángel Palacios-Pedrero, Albert D. M. E. Osterhaus, Tanja Becker, Husni Elbahesh, Guus F. Rimmelzwaan, Giulietta Saletti
Publié dans: Frontiers in Immunology, Numéro 12, 2021, ISSN 1664-3224
Éditeur: IUIS
DOI: 10.3389/fimmu.2021.681449

FDA-approved Abl/EGFR/PDGFR kinase inhibitors show potent efficacy against pandemic and seasonal influenza A virus infections of human lung explants

Auteurs: Robert Meineke et al.
Publié dans: iScience, 2023, ISSN 2589-0042
Éditeur: Elsevier
DOI: 10.1016/j.isci.2023.106309

Middle East Respiratory Syndrome Coronavirus Gene 5 Modulates Pathogenesis in Mice

Auteurs: Javier Gutierrez-Alvarez, Li Wang, Raul Fernandez-Delgado, Kun Li, Paul B. McCray, Stanley Perlman, Isabel Sola, Sonia Zuñiga, Luis Enjuanes
Publié dans: Journal of Virology, Numéro 95, 2022, ISSN 0022-538X
Éditeur: American Society for Microbiology
DOI: 10.1128/jvi.01172-20

mRNA Vaccines against SARS-CoV-2: Advantages and Caveats

Auteurs: Miriam Echaide et al.
Publié dans: Int J Mol Sci, 2023, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24065944

Signs of immunosenescence correlate with poor outcome of mRNA COVID-19 vaccination in older adults

Auteurs: Palacios-Pedrero, M.Á., Jansen, J.M., Blume, C. et al.
Publié dans: Nat Aging, 2022, ISSN 2662-8465
Éditeur: Springer Nature
DOI: 10.1038/s43587-022-00292-y

Canonical and Noncanonical Autophagy as Potential Targets for COVID-19

Auteurs: Melissa Bello-Perez, Isabel Sola, Beatriz Novoa, Daniel J. Klionsky, Alberto Falco
Publié dans: Cells, Numéro 9/7, 2020, Page(s) 1619, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells9071619

Genetically Engineered Live-Attenuated Middle East Respiratory Syndrome Coronavirus Viruses Confer Full Protection against Lethal Infection

Auteurs: Javier Gutiérrez-Álvarez, José M. Honrubia, Raúl Fernández-Delgado, Li Wang, Carlos Castaño-Rodríguez, Sonia Zúñiga, Isabel Sola, Luis Enjuanes
Publié dans: mBio, Numéro 12/2, 2021, ISSN 2150-7511
Éditeur: ASM Journals
DOI: 10.1128/mbio.00103-21

Cutting-Edge: Preclinical and Clinical Development of the First Approved Lag-3 Inhibitor

Auteurs: Chocarro, Luisa, Ana Bocanegra, Ester Blanco, Leticia Fernández-Rubio, Hugo Arasanz, Miriam Echaide, Maider Garnica, Pablo Ramos, Sergio Piñeiro-Hermida, Ruth Vera, David Escors, and Grazyna Kochan
Publié dans: Cells, Numéro 20782489, 2022, Page(s) 2351, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11152351

MERS-CoV ORF4b is a virulence factor involved in the inflammatory pathology induced in the lungs of mice

Auteurs: Bello-Perez M, Hurtado-Tamayo J, Requena-Platek R, Canton J, Sánchez-Cordón PJ, Fernandez-Delgado R, et al
Publié dans: PLoS Pathog, Numéro 19326203, 2022, Page(s) e1010834, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.ppat.1010834

Clinical landscape of LAG-3-targeted therapy

Auteurs: L. Chocarro et al.
Publié dans: Immuno-Oncology and Technology, 2022, ISSN 2590-0188
Éditeur: Elsevier
DOI: 10.1016/j.iotech.2022.100079

A Proteomic Atlas of Lineage and Cancer-Polarized Expression Modules in Myeloid Cells Modeling Immunosuppressive Tumor-Infiltrating Subsets

Auteurs: Ester Blanco, Maria Ibañez-Vea, Carlos Hernandez, Lylia Drici, Xabier Martínez de Morentin, Maria Gato, Karina Ausin, Ana Bocanegra, Miren Zuazo, Luisa Chocarro, Hugo Arasanz, Gonzalo Fernandez-Hinojal, Joaquin Fernandez-Irigoyen, Cristian Smerdou, Maider Garnica, Miriam Echaide, Leticia Fernandez, Pilar Morente, Pablo Ramos-Castellanos, Diana Llopiz, Enrique Santamaria, Martin R. Larsen, David
Publié dans: Journal of Personalized Medicine, Numéro 11/6, 2021, Page(s) 542, ISSN 2075-4426
Éditeur: MDPI
DOI: 10.3390/jpm11060542

Tick-borne encephalitis vaccine breakthrough infections induce aberrant T cell and antibody responses to non-structural proteins

Auteurs: Amare Aregay, Jan Slunečko, Miša Korva, Petra Bogovic, Katarina Resman Rus, Nataša Knap, Jana Beicht, Mareike Kubinski, Giulietta Saletti, Tatjana Avšič-Županc, Imke Steffen, Franc Strle, Albert D. M. E. Osterhaus, Guus F. Rimmelzwaan
Publié dans: npj Vaccines, Numéro 9, 2024, ISSN 2059-0105
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/s41541-024-00936-7

Sicilian semi- and supercentenarians: age-related NK cell immunophenotype and longevity trait definition

Auteurs: Ligotti et al.
Publié dans: Translational Medicine @UniSA, 2023, ISSN 2239-9747
Éditeur: UniSA
DOI: 10.37825/2239-9747.1041

Leading Edge: Intratumor Delivery of Monoclonal Antibodies for the Treatment of Solid Tumors

Auteurs: Esther Blanco et al.
Publié dans: Int J Mol Sci, 2023, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24032676

Contribution to pathogenesis of accessory proteins of deadly human coronaviruses

Auteurs: Jesus Hurtado-Tamayo et al.
Publié dans: Front. Cell. Infect. Microbiol, 2023, ISSN 2235-2988
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fcimb.2023.1166839

The Role of Immunogenetics in COVID-19

Auteurs: Fanny Pojero, Giuseppina Candore, Calogero Caruso, Danilo Di Bona, David A. Groneberg, Mattia E. Ligotti, Giulia Accardi, Anna Aiello
Publié dans: International Journal of Molecular Sciences, Numéro 22/5, 2021, Page(s) 2636, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22052636

Middle East respiratory syndrome coronavirus vaccine based on a propagation-defective RNA replicon elicited sterilizing immunity in mice

Auteurs: J. Gutiérrez-Álvarez, J. M. Honrubia, A. Sanz-Bravo, E. González-Miranda, R. Fernández-Delgado, M. T. Rejas, S. Zúñiga, I. Sola, L. Enjuanes
Publié dans: Proceedings of the National Academy of Sciences, Numéro 118, 2022, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.2111075118

Sicilian semi- and supercentenarians: identification of age-related T-cell immunophenotype to define longevity trait

Auteurs: Mattia Emanuela Ligotti, Giulia Accardi, Anna Aiello, Stefano Aprile, Anna Calabrò, Rosalia Caldarella, Calogero Caruso, Marcello Ciaccio, Anna Maria Corsale, Francesco Dieli, Marta Di Simone, Giovanni Maurizio Giammanco, Chiara Mascarella, Arne N Akbar, Serena Meraviglia, Giuseppina Candore
Publié dans: Clinical and Experimental Immunology, Numéro 214, 2023, Page(s) 61-78, ISSN 0009-9104
Éditeur: Blackwell Publishing Inc.
DOI: 10.1093/cei/uxad074

Influenza Vaccines: Successes and Continuing Challenges

Auteurs: Tanja Becker, Husni Elbahesh, Leslie A Reperant, Guus F Rimmelzwaan, Albert D M E Osterhaus
Publié dans: The Journal of Infectious Diseases, Numéro 224/Supplement_4, 2021, Page(s) S405-S419, ISSN 0022-1899
Éditeur: University of Chicago Press
DOI: 10.1093/infdis/jiab269

Poor virus-specific T-cell responses early after tick-borne encephalitis virus infection correlate with disease severity

Auteurs: Amare Aregay, Jan Slunečko, Petra Bogovic, Miša Korva, Katarina Resman Rus, Nataša Knap, Jana Beicht, Mareike Kubinski, Giulietta Saletti, Imke Steffen, Franc Strle, Tatjana Avšič-Županc, Albert D.M.E. Osterhaus, Guus F. Rimmelzwaan
Publié dans: Emerging Microbes & Infections, Numéro 13, 2024, ISSN 2222-1751
Éditeur: Nature Publishing Group
DOI: 10.1080/22221751.2024.2317909

4P CBL-B inhibition overcomes PD-1/LAG-3 mediated resistance in lung cancer

Auteurs: L.D.E. Chocarro, E. Blanco, L. Fenández-Rubio, M. Garnica, M. Zuazo, M.J. Garcia Granda, A. Bocanegra, M. Echaide, C. Johnston, C.J. Edwards, J. Legg, A. Pierce, H. Arasanz, G. Fernandez-Hinojal, R. Vera, K. Ausin, E. Santamaría, J. Fernández-Irigoyen, G. Kochan, D. Escors
Publié dans: Annals of Oncology, Numéro 35, 2024, Page(s) S216, ISSN 0923-7534
Éditeur: Oxford University Press
DOI: 10.1016/j.annonc.2024.08.014

Longitudinal Immunoprofiling of the CD8+ T-Cell Response in SARS-CoV-2 mRNA Vaccinees and COVID-19 Patients

Auteurs: Jesús Emanuel Brunetti, Beatriz Escudero-Pérez, Fátima Lasala, Gonzalo Rivas, Mikel Mancheño-Losa, David Rial-Crestelo, Jaime Lora-Tamayo, Dániel Cadar, Miles Carroll, Rafael Delgado, César Muñoz-Fontela, Estefanía Rodríguez
Publié dans: Vaccines, Numéro 13, 2025, Page(s) 551, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines13060551

Cytoplasmic ribonucleoprotein complexes, RNA helicases and coronavirus infection

Auteurs: Li Wang, María Guzmán, Isabel Sola, Luis Enjuanes, Sonia Zuñiga
Publié dans: Frontiers in Virology, Numéro 2, 2022, ISSN 2673-818X
Éditeur: Frontiers Media SA
DOI: 10.3389/fviro.2022.1078454

Sex and gender affect immune aging

Auteurs: Calabro et al.
Publié dans: Front Aging, 2023, ISSN 2673-6217
Éditeur: Frontiers
DOI: 10.3389/fragi.2023.1272118

Senotherapeutics to Counteract Senescent Cells Are Prominent Topics in the Context of Anti-Ageing Strategies

Auteurs: Anna Calabrò, Giulia Accardi, Anna Aiello, Calogero Caruso, Damiano Galimberti, Giuseppina Candore
Publié dans: International Journal of Molecular Sciences, Numéro 25, 2024, Page(s) 1792, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25031792

Contribution of Host miRNA-223-3p to SARS-CoV-Induced Lung Inflammatory Pathology

Auteurs: Lucía Morales; Juan Carlos Oliveros; Luis Enjuanes; Isabel Sola
Publié dans: mBio, Numéro 00219193, 2022, ISSN 0021-9193
Éditeur: American Society for Microbiology
DOI: 10.1128/mbio.03135-21

Metabolic dyshomeostasis induced by SARS-CoV-2 structural proteins reveals immunological insights into viral olfactory interactions

Auteurs: Mercedes Lachén-Montes et al.
Publié dans: Front. Immunol., 2022, ISSN 1664-3224
Éditeur: Frontiers Media
DOI: 10.3389/fimmu.2022.866564

SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in cell culture and in mice

Auteurs: Yousef M. Alhammad, et al.
Publié dans: PNAS, 2023, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.2302083120

Role of Sex and Age in Fatal Outcomes of COVID-19: Women and Older Centenarians Are More Resilient

Auteurs: Caruso et al.
Publié dans: Int J Mol Sci, 2023, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24032638

Enhancing flu vaccine responses in older adults: preliminary insights from the ISOLDA study on immunosenescence and antioxidant and anti-inflammatory approaches

Auteurs: Anna Aiello, Anna Calabrò, Mattia Emanuela Ligotti, Giulia Accardi, Mojtaba Shekarkar Azgomi, Nadia Caccamo, Calogero Caruso, Francesco Dieli, Marco Pio La Manna, Antonio Procopio, Giuseppina Candore
Publié dans: Immunity & Ageing, Numéro 22, 2025, ISSN 1742-4933
Éditeur: BioMed Central
DOI: 10.1186/s12979-025-00506-y

The Phenotypic Characterization of the Oldest Italian Man from December 28, 2020, to September 23, 2021, A.T., Strengthens the Idea That the Immune System can Play a Key Role in the Attainment of Extreme Longevity

Auteurs: Giulia Accardi, Anna Aiello, Stefano Aprile, Anna Calabrò, Rosalia Caldarella, Calogero Caruso, Marcello Ciaccio, Francesco Dieli, Mattia Emanuela Ligotti, Serena Meraviglia, Giuseppina Candore
Publié dans: Journal of Clinical Medicine, Numéro 12, 2023, Page(s) 7591, ISSN 2077-0383
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm12247591

Nature of viruses and pandemics: Coronaviruses

Auteurs: Luis Enjuanes, Isabel Sola, Sonia Zúñiga, José M. Honrubia, Melissa Bello-Pérez, Alejandro Sanz-Bravo, Ezequiel González-Miranda, Jesús Hurtado-Tamayo, Ricardo Requena-Platek, Li Wang, Diego Muñoz-Santos, Carlos M. Sánchez, Ana Esteban, Jorge Ripoll-Gómez
Publié dans: Current Research in Immunology, Numéro 3, 2024, Page(s) 151-158, ISSN 2590-2555
Éditeur: Elsevier BV
DOI: 10.1016/j.crimmu.2022.08.003

An immunologist’s guide to immunosenescence and its treatment

Auteurs: Calogero Caruso, Mattia Emanuela Ligotti, Giulia Accardi, Anna Aiello & Giuseppina Candore
Publié dans: Expert Review of Clinical Immunology, Numéro 21547343, 2022, Page(s) 961-981, ISSN 2154-7343
Éditeur: Taylor and Francis
DOI: 10.1080/1744666x.2022.2106217

How Important Are Genes to Achieve Longevity?

Auteurs: Caruso, C.; Ligotti, M.E.; Accardi, G.; Aiello, A.; Duro, G.; Galimberti, D.; Candore, G.
Publié dans: Int. J. Mol. Sci., Numéro 23046775, 2022, Page(s) 5635, ISSN 2304-6775
Éditeur: MDPI
DOI: 10.3390/ijms23105635

Immunopathology and Immunosenescence, the Immunological Key Words of Severe COVID-19. Is There a Role for Stem Cell Transplantation?

Auteurs: Ligotti ME, Pojero F, Accardi G, Aiello A, Caruso C, Duro G and Candore G
Publié dans: Front. Immunol., Numéro 2297198X, 2021, Page(s) 627548, ISSN 2297-198X
Éditeur: Frontiers
DOI: 10.3389/fcell.2021.725606

How Can We Improve Vaccination Response in Old People? Part I: Targeting Immunosenescence of Innate Immunity Cells

Auteurs: Aiello, A.; Ligotti, M.E.; Garnica, M.; Accardi, G.; Calabrò, A.; Pojero, F.; Arasanz, H.; Bocanegra, A.; Blanco, E.; Chocarro, L.; Echaide, M.; Fernandez-Rubio, L.; Ramos, P.; Piñeiro-Hermida, S.; Kochan, G.; Zareian, N.; Farzaneh, F.; Escors, D.; Caruso, C.; Candore, G.
Publié dans: Int. J. Mol. Sci., Numéro 23046775, 2022, Page(s) 9880, ISSN 2304-6775
Éditeur: MDPI
DOI: 10.3390/ijms23179880

Lessons from Sicilian centenarians for anti-ageing medicine. The Oxi-inflammatory status

Auteurs: Caruso, Calogero; Accardi, Giulia; Aiello, Anna; Calabrò, Anna; Ligotti, Mattia Emanuela; and Candore, Giuseppina
Publié dans: Translational Medicine @ UniSa, Numéro 22833838, 2022, ISSN 2283-3838
Éditeur: Centro Nazionale
DOI: 10.37825/2239-9747.1036

Clinical landscape of LAG-3-targeted therapy

Auteurs: L. Chocarro et al.
Publié dans: 2021
Éditeur: Oxford University Press
DOI: 10.1016/j.annonc.2021.08.2051

Identification of a PD-1/LAG-3 co-expression profile in human tumor-infiltrating T cells uncovers a T cell dysfunctionality genetic regulated programme

Auteurs: L. Chocarro et al.
Publié dans: Annals of Oncology, 2022
Éditeur: Oxford University Press
DOI: 10.1016/j.annonc.2022.07.067

15P CBL E3 ubiquitin ligases are key inhibitory regulators in PD-1/LAG-3 co-signaling in human cancers, targeted through bispecific co-blockade

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DOI: 10.1016/j.annonc.2023.09.1518

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Éditeur: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.03.10.23287087

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Éditeur: TiHo

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Publié dans: 2025
Éditeur: UNIPA

Potent clinical predictive and systemic adjuvant therapeutic value of plasma fractalkine in PD-L1/PD-1 blockade immunotherapy for lung cancer

Auteurs: Ana Bocanegra, Gonzalo Fernández, Daniel Ajona, Hugo Arasanz, Ester Blanco, Miren Zuazo, Luisa Chocarro, Sergio Piñeiro-Hermida, Pilar Morente, Leticia Fernández, Maider Garnica, Ana Remirez, Maite Martinez-Aguillo, Idoia Morilla, Beatriz Tavira, Pablo Ramos, Miriam Echaide, Juan José Lasarte, Luis Montuenga, Ruth Vera, Ruben Pio, David Escors, Grazyna Kochan
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Éditeur: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.06.16.22276511

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