Development, dIagnostic and prevention of gender-related Somatic and mental COmorbitiEs in iRritable bowel syndrome In Europe

Informations projet

DISCOvERIE

N° de convention de subvention: 848228

DOI

10.3030/848228

Projet clôturé

Date de signature de la CE 13 Decembre 2019

Date de début 1 Janvier 2020

Date de fin 31 Mai 2025

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total

€ 6 000 000,00

Contribution de l’UE

€ 6 000 000,00

Coordonné par

FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA
Spain

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (13)

Mechanistically-oriented sex-specific molecular signature of IBS comorbidities following animal and human microbiota transfer

Mechanistically-oriented sex-specific molecular signature of IBS comorbidities following animal and human microbiota transfer (M40).

Report on IBS pattern comorbidities in retrospective cohorts

Report on IBS pattern comorbidities in retrospective cohorts (M16).

Report on candidate mechanisms for comorbid development and mechanistic biomarkers from existing data

Report on candidate mechanisms for comorbid development and mechanistic biomarkers from existing data (M18).

Report on candidate mechanisms and biomarkers for comorbid IBS

Report on candidate mechanisms and biomarkers for comorbid IBS (M48).

Report on effect of approved drugs on candidate mechanisms

Report on effect of approved drugs on candidate mechanisms (M48).

To integrate the data provided by ESM app and HumanITcare platform with data from WP2-6 and to feed the repository

To integrate the data provided by ESM app and HumanITcare platform with data from WP2-6 and to feed the repository (M40).

Intestinal mucosal profiling of mechanisms of barrier dysfunction that differentiate IBS from comorbid IBS

Intestinal mucosal profiling of mechanisms of barrier dysfunction that differentiate IBS from comorbid IBS (M36).

Report on fecal sampling and transport of IBS cohorts in the project and the quantitative microbiome profiling

Report on fecal sampling and transport of IBS cohorts in the project and the quantitativemicrobiome profiling (M30).

Report on IBS pattern comorbidities in prospectively deeply phenotyped cohorts

Report on IBS pattern comorbidities in prospectively deeply phenotyped cohorts (M36).

Confirmation of transfer of comorbid IBS phenotypes from animal models and from human samples

Confirmation of transfer of comorbid IBS phenotypes from animal models and from humansamples (M40).

Identification of common genetic variants involved in IBS and comorbidities

Identification of common genetic variants involved in IBS and comorbidities (M36).

"Profiling of ""gut-to-brain"" and ""brain-to-gut"" mechanisms associated with comorbidities development in IBS"

Profiling of “gut-to-brain” and “brain-to-gut” mechanisms associated with comorbiditiesdevelopment in IBS (M36).

Report on microbiome and metabolome profiling in IBS and comorbid IBS

Report on microbiome and metabolome profiling in IBS and comorbid IBS (M31).

Websites, patent fillings, videos etc. (1)

Launch project identity, brochure and public website

Launch project identity, brochure and public website (M6).

Publications

Peer reviewed articles (9)

Gut microbiota composition links to variation in functional domains across psychiatric disorders

Auteurs: Danique Mulder, Babette Jakobi, Yingjie Shi, Peter Mulders, Josina D. Kist, Rose M. Collard, Janna N. Vrijsen, Phillip van Eijndhoven, Indira Tendolkar, Mirjam Bloemendaal, Alejandro Arias Vasquez
Publié dans: Brain, Behavior, and Immunity, Numéro 120, 2024, Page(s) 275-287, ISSN 0889-1591
Éditeur: Academic Press
DOI: 10.1016/j.bbi.2024.05.037

Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new genetic hits

Auteurs: Silvia Alemany; María Soler Artigas; Judit Cabana; Dana Salim Fakhreddine; Natalia Llonga; Laura Vilar-Ribó; Amanda Rodríguez-Urrutia; Judit Palacio; Ana María González-Castro; Beatriz Lobo; Carmen Alonso-Cotoner; Magnus Simrén; Javier Santos; Josep Antoni Ramos-Quiroga; Marta Ribasés
Publié dans: Journal of Transnational Medicine, Numéro 3, 2023, ISSN 1479-5876
Éditeur: BioMed Central
DOI: 10.1101/2023.01.30.23285080

The effect of expectancy versus actual gluten intake on gastrointestinal and extra-intestinal symptoms in non-coeliac gluten sensitivity: a randomised, double-blind, placebo-controlled, international, multicentre study

Auteurs: Marlijne C G de Graaf, Clare L Lawton, Fiona Croden, Agnieszka Smolinska, Bjorn Winkens, Martine A M Hesselink, Gonny van Rooy, Peter L Weegels, Peter R Shewry, Peter D Mooney, Lesley A Houghton, Ben J M Witteman, Daniel Keszthelyi, Fred J P H Brouns, Louise Dye, Daisy M A E Jonkers
Publié dans: The Lancet Gastroenterology & Hepatology, Numéro 9, 2025, Page(s) 110-123, ISSN 2468-1253
Éditeur: Elsevier BV
DOI: 10.1016/s2468-1253(23)00317-5

Sex specific gut-microbiota signatures of resilient and comorbid gut-brain phenotypes induced by early life stress

Auteurs: Lars Wilmes, Valentina Caputi, Thomaz F.S. Bastiaanssen, James M. Collins, Fiona Crispie, Paul D. Cotter, Timothy G. Dinan, John F. Cryan, Gerard Clarke, Siobhain M. O'Mahony
Publié dans: Neurobiology of Stress, Numéro 33, 2024, Page(s) 100686, ISSN 2352-2895
Éditeur: Elsevier BV
DOI: 10.1016/j.ynstr.2024.100686

Refining physical exercise training studies in patients with inflammatory bowel disease: patient selection and assessment of physical fitness changes

Auteurs: Karlijn Demers, Bart C. Bongers, Daisy M. A. E. Jonkers, Marieke J. Pierik, Laurents P. S. Stassen
Publié dans: Trials, Numéro 25, 2024, ISSN 1745-6215
Éditeur: BioMed Central
DOI: 10.1186/s13063-024-08163-0

Of bowels, brain and behavior: A role for the gut microbiota in psychiatric comorbidities in irritable bowel syndrome

Auteurs: Lars Wilmes, James M. Collins, Kenneth J. O'Riordan, Siobhain M. O’Mahony, John F. Cryan, Gerard Clarke
Publié dans: Neurogastroenterology & Motility, Numéro 33/3, 2021, ISSN 1350-1925
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/nmo.14095

Investigating causality with fecal microbiota transplantation in rodents: applications, recommendations and pitfalls.

Auteurs: Cassandra E. Gheorghe; Nathaniel L. Ritz; Jason A. Martin; Hannah R. Wardill; John F. Cryan; Gerard Clarke
Publié dans: Gut Microbes, Vol 13, Iss 1 (2021), Numéro 3, 2021, ISSN 1949-0984
Éditeur: Gut Microbes (Taylor & Francis Group)
DOI: 10.1080/19490976.2021.1941711

Criterion Validity of Screening Tools and Field-Based Tests for Health-Related Physical Fitness in Inflammatory Bowel Disease

Auteurs: Karlijn Demers, Bart C. Bongers, Sander M. J. van Kuijk, Guy Plasqui, Daisy M. A. E. Jonkers, Marieke J. Pierik, Laurents P. S. Stassen
Publié dans: Digestive Diseases and Sciences, Numéro 69, 2024, Page(s) 4072-4088, ISSN 0163-2116
Éditeur: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10620-024-08682-5

A trial‐based economic evaluation of peppermint oil for the treatment of irritable bowel syndrome

Auteurs: Zsa Zsa R. M. Weerts, Brigitte A. B. Essers, Daisy M. A. E. Jonkers, Jeresa I. A. Willems, Deborah J. P. A. Janssen, Ben J. M. Witteman, Cees H. M. Clemens, Audrey Westendorp, Ad A. M. Masclee, Daniel Keszthelyi
Publié dans: United European Gastroenterology Journal, Numéro 9, 2023, Page(s) 997-1006, ISSN 2050-6406
Éditeur: Wiley
DOI: 10.1002/ueg2.12134