Development, dIagnostic and prevention of gender-related Somatic and mental COmorbitiEs in iRritable bowel syndrome In Europe

Información del proyecto

DISCOvERIE

Identificador del acuerdo de subvención: 848228

DOI

10.3030/848228

Proyecto cerrado

Fecha de la firma de la CE 13 Diciembre 2019

Fecha de inicio 1 Enero 2020

Fecha de finalización 31 Mayo 2025

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total

€ 6 000 000,00

Aportación de la UE

€ 6 000 000,00

Coordinado por

FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA
Spain

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (13)

Mechanistically-oriented sex-specific molecular signature of IBS comorbidities following animal and human microbiota transfer

Mechanistically-oriented sex-specific molecular signature of IBS comorbidities following animal and human microbiota transfer (M40).

Report on IBS pattern comorbidities in retrospective cohorts

Report on IBS pattern comorbidities in retrospective cohorts (M16).

Report on candidate mechanisms for comorbid development and mechanistic biomarkers from existing data

Report on candidate mechanisms for comorbid development and mechanistic biomarkers from existing data (M18).

Report on candidate mechanisms and biomarkers for comorbid IBS

Report on candidate mechanisms and biomarkers for comorbid IBS (M48).

Report on effect of approved drugs on candidate mechanisms

Report on effect of approved drugs on candidate mechanisms (M48).

To integrate the data provided by ESM app and HumanITcare platform with data from WP2-6 and to feed the repository

To integrate the data provided by ESM app and HumanITcare platform with data from WP2-6 and to feed the repository (M40).

Intestinal mucosal profiling of mechanisms of barrier dysfunction that differentiate IBS from comorbid IBS

Intestinal mucosal profiling of mechanisms of barrier dysfunction that differentiate IBS from comorbid IBS (M36).

Report on fecal sampling and transport of IBS cohorts in the project and the quantitative microbiome profiling

Report on fecal sampling and transport of IBS cohorts in the project and the quantitativemicrobiome profiling (M30).

Report on IBS pattern comorbidities in prospectively deeply phenotyped cohorts

Report on IBS pattern comorbidities in prospectively deeply phenotyped cohorts (M36).

Confirmation of transfer of comorbid IBS phenotypes from animal models and from human samples

Confirmation of transfer of comorbid IBS phenotypes from animal models and from humansamples (M40).

Identification of common genetic variants involved in IBS and comorbidities

Identification of common genetic variants involved in IBS and comorbidities (M36).

"Profiling of ""gut-to-brain"" and ""brain-to-gut"" mechanisms associated with comorbidities development in IBS"

Profiling of “gut-to-brain” and “brain-to-gut” mechanisms associated with comorbiditiesdevelopment in IBS (M36).

Report on microbiome and metabolome profiling in IBS and comorbid IBS

Report on microbiome and metabolome profiling in IBS and comorbid IBS (M31).

Websites, patent fillings, videos etc. (1)

Launch project identity, brochure and public website

Launch project identity, brochure and public website (M6).

Publicaciones

Peer reviewed articles (9)

Gut microbiota composition links to variation in functional domains across psychiatric disorders

Autores: Danique Mulder, Babette Jakobi, Yingjie Shi, Peter Mulders, Josina D. Kist, Rose M. Collard, Janna N. Vrijsen, Phillip van Eijndhoven, Indira Tendolkar, Mirjam Bloemendaal, Alejandro Arias Vasquez
Publicado en: Brain, Behavior, and Immunity, Edición 120, 2024, Página(s) 275-287, ISSN 0889-1591
Editor: Academic Press
DOI: 10.1016/j.bbi.2024.05.037

Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new genetic hits

Autores: Silvia Alemany; María Soler Artigas; Judit Cabana; Dana Salim Fakhreddine; Natalia Llonga; Laura Vilar-Ribó; Amanda Rodríguez-Urrutia; Judit Palacio; Ana María González-Castro; Beatriz Lobo; Carmen Alonso-Cotoner; Magnus Simrén; Javier Santos; Josep Antoni Ramos-Quiroga; Marta Ribasés
Publicado en: Journal of Transnational Medicine, Edición 3, 2023, ISSN 1479-5876
Editor: BioMed Central
DOI: 10.1101/2023.01.30.23285080

The effect of expectancy versus actual gluten intake on gastrointestinal and extra-intestinal symptoms in non-coeliac gluten sensitivity: a randomised, double-blind, placebo-controlled, international, multicentre study

Autores: Marlijne C G de Graaf, Clare L Lawton, Fiona Croden, Agnieszka Smolinska, Bjorn Winkens, Martine A M Hesselink, Gonny van Rooy, Peter L Weegels, Peter R Shewry, Peter D Mooney, Lesley A Houghton, Ben J M Witteman, Daniel Keszthelyi, Fred J P H Brouns, Louise Dye, Daisy M A E Jonkers
Publicado en: The Lancet Gastroenterology & Hepatology, Edición 9, 2025, Página(s) 110-123, ISSN 2468-1253
Editor: Elsevier BV
DOI: 10.1016/s2468-1253(23)00317-5

Sex specific gut-microbiota signatures of resilient and comorbid gut-brain phenotypes induced by early life stress

Autores: Lars Wilmes, Valentina Caputi, Thomaz F.S. Bastiaanssen, James M. Collins, Fiona Crispie, Paul D. Cotter, Timothy G. Dinan, John F. Cryan, Gerard Clarke, Siobhain M. O'Mahony
Publicado en: Neurobiology of Stress, Edición 33, 2024, Página(s) 100686, ISSN 2352-2895
Editor: Elsevier BV
DOI: 10.1016/j.ynstr.2024.100686

Refining physical exercise training studies in patients with inflammatory bowel disease: patient selection and assessment of physical fitness changes

Autores: Karlijn Demers, Bart C. Bongers, Daisy M. A. E. Jonkers, Marieke J. Pierik, Laurents P. S. Stassen
Publicado en: Trials, Edición 25, 2024, ISSN 1745-6215
Editor: BioMed Central
DOI: 10.1186/s13063-024-08163-0

Of bowels, brain and behavior: A role for the gut microbiota in psychiatric comorbidities in irritable bowel syndrome

Autores: Lars Wilmes, James M. Collins, Kenneth J. O'Riordan, Siobhain M. O’Mahony, John F. Cryan, Gerard Clarke
Publicado en: Neurogastroenterology & Motility, Edición 33/3, 2021, ISSN 1350-1925
Editor: Blackwell Publishing Inc.
DOI: 10.1111/nmo.14095

Investigating causality with fecal microbiota transplantation in rodents: applications, recommendations and pitfalls.

Autores: Cassandra E. Gheorghe; Nathaniel L. Ritz; Jason A. Martin; Hannah R. Wardill; John F. Cryan; Gerard Clarke
Publicado en: Gut Microbes, Vol 13, Iss 1 (2021), Edición 3, 2021, ISSN 1949-0984
Editor: Gut Microbes (Taylor & Francis Group)
DOI: 10.1080/19490976.2021.1941711

Criterion Validity of Screening Tools and Field-Based Tests for Health-Related Physical Fitness in Inflammatory Bowel Disease

Autores: Karlijn Demers, Bart C. Bongers, Sander M. J. van Kuijk, Guy Plasqui, Daisy M. A. E. Jonkers, Marieke J. Pierik, Laurents P. S. Stassen
Publicado en: Digestive Diseases and Sciences, Edición 69, 2024, Página(s) 4072-4088, ISSN 0163-2116
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10620-024-08682-5

A trial‐based economic evaluation of peppermint oil for the treatment of irritable bowel syndrome

Autores: Zsa Zsa R. M. Weerts, Brigitte A. B. Essers, Daisy M. A. E. Jonkers, Jeresa I. A. Willems, Deborah J. P. A. Janssen, Ben J. M. Witteman, Cees H. M. Clemens, Audrey Westendorp, Ad A. M. Masclee, Daniel Keszthelyi
Publicado en: United European Gastroenterology Journal, Edición 9, 2023, Página(s) 997-1006, ISSN 2050-6406
Editor: Wiley
DOI: 10.1002/ueg2.12134