Resilience and Trigger Factors in Cardiac Arrhythmia: Risk Stratification and Drug Design

Project Information

MOLEC ANTI-ARRHYT

Grant agreement ID: 850622

DOI

10.3030/850622

EC signature date 8 October 2019

Start date 1 March 2020

End date 30 November 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 998,00

EU contribution

€ 1 499 998,00

Coordinated by

LINKOPINGS UNIVERSITET
Sweden

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (12)

Mechanistic insights into robust cardiac IKs potassium channel activation by aromatic polyunsaturated fatty acid analogues

Author(s): Bohannon, BM; Jowais, JJ; Nyberg, L; Olivier-Meo, V; Corradi, V; Tieleman, DP; Liin, SI; Larsson HP
Published in: Elife, Issue Jun 23, 2023, Page(s) e85773, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.85773

Rescue of loss‐of‐function long QT syndrome‐associated mutations in K_V7.1/KCNE1 by the endocannabinoid N‐arachidonoyl‐L‐serine (ARA‐S)

Author(s): Irene Hiniesto‐Iñigo, Akshay Sridhar, Julien Louradour, Alicia De la Cruz, Siri Lundholm, Amaia Jauregi‐Miguel, Federica Giannetti, Luca Sala, Katja E. Odening, H. Peter Larsson, Nina E. Ottosson, Sara I. Liin
Published in: British Journal of Pharmacology, 2025, ISSN 0007-1188
Publisher: Wiley-Blackwell
DOI: 10.1111/bph.70008

The endocannabinoid ARA-S facilitates the activation of cardiac Kv7.1/KCNE1 channels from different species

Author(s): Irene Hiniesto-Iñigo, Veronika A. Linhart, Ali S. Kusay, Sara I. Liin
Published in: Channels, Issue 18, 2024, ISSN 1933-6950
Publisher: Landes Bioscience
DOI: 10.1080/19336950.2024.2420651

Pharmacological Screening of Kv7.1 and Kv7.1/KCNE1 Activators as Potential Antiarrhythmic Drugs in the Zebrafish Heart

Author(s): De la Cruz, A; Wu, X; Rainer, QC; Hiniesto-Iñigo, I; Perez ME; Edler, I; Liin, SI; Larsson, HP
Published in: International journal of molecular sciences, Issue 24(15), 2023, Page(s) 12092, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms241512092

Subtype-specific modulation of human KV7 channels by theanticonvulsant cannabidiol through a lipid-exposedpore-domain site

Author(s): Pökl, M; Sridhar, A; Frampton, DFA; Linhart, VA; Delemotte, L; Liin, SI
Published in: British Journal of Pharmacology, Issue Jun 28, 2023, Page(s) 16183, ISSN 0007-1188
Publisher: Wiley-Blackwell
DOI: 10.1111/bph.16183

Faradaic Pixels for Precise Hydrogen Peroxide Delivery toControl M-Type Voltage-Gated Potassium Channels

Author(s): Oliya S. Abdullaeva, Ihor Sahalianov, Malin Silverå Ejneby, Marie Jakešová, Igor Zozoulenko, Sara I. Liin, and Eric Daniel Głowacki
Published in: Advanced Science, Issue 21983844, 2022, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202103132

Polyunsaturated Fatty Acids as Modulators of KV7 Channels

Author(s): Johan E. Larsson, Damon J. A. Frampton, Sara I. Liin
Published in: Frontiers in Physiology, Issue 11, 2020, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.00641

Identification of PUFA interaction sites on the cardiac potassium channel KCNQ1

Author(s): Samira Yazdi, Johan Nikesjö, Williams Miranda, Valentina Corradi, D. Peter Tieleman, Sergei Yu. Noskov, H. Peter Larsson, Sara I. Liin
Published in: Journal of General Physiology, Issue 153/6, 2021, ISSN 0022-1295
Publisher: Rockefeller University Press
DOI: 10.1085/jgp.202012850

Docosahexaenoic acid normalizes QT interval in long QT type 2 transgenic rabbit models in a genotype-specific fashion

Author(s): Alessandro Castiglione, Tibor Hornyik, Eike M Wülfers, Lucilla Giammarino, Iask Edler, Jessica J Jowais, Marina Rieder, Stefanie Perez-Feliz, Gideon Koren, Zsuzsanna Bősze, András Varró, Manfred Zehender, Michael Brunner, Christoph Bode, Sara I. Liin, Hans Peter Larsson, István Baczkó, Katja E Odening
Published in: Europace, Issue 15322092, 2022, ISSN 1532-2092
Publisher: Oxford University Press
DOI: 10.1093/europace/euab228

Mechanistic understanding of KCNQ1 activating polyunsaturated fatty acid analogs

Author(s): Jowais, JJ; Yazdi, S; Golluscio, A; Olivier-Meo, V; Liin, SI; Larsson, HP
Published in: Journal of general physiology, Issue 155(10), 2023, Page(s) e202313339, ISSN 1540-7748
Publisher: Rockefeller University Press
DOI: 10.1085/jgp.202313339

Long-QT mutations in KCNE1 modulate the 17β-estradiol response of Kv7.1/KCNE1

Author(s): Lisa-Marie Erlandsdotter, Lucilla Giammarino, Azemine Halili, Johan Nikesjö, Henrik Gréen, Katja E Odening, Sara I Liin
Published in: Science Advances, 2023, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.ade7109

Endocannabinoids enhance hKV7.1/KCNE1 channel function and shorten the cardiac action potential and QT interval

Author(s): Irene Hiniesto-Iñigo, Laura M Castro-Gonzalez, Valentina Corradi, Mark A Skarsfeldt, Samira Yazdi, Siri Lundholm, Johan Nikesjö, Sergei Yu Noskov, Bo Hjorth Bentzen, D Peter Tieleman, Sara I Liin
Published in: Lancet eBioMedicine, 2023, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2023.104459