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Resilience and Trigger Factors in Cardiac Arrhythmia: Risk Stratification and Drug Design

Publications

Mechanistic insights into robust cardiac IKs potassium channel activation by aromatic polyunsaturated fatty acid analogues

Author(s): Bohannon, BM; Jowais, JJ; Nyberg, L; Olivier-Meo, V; Corradi, V; Tieleman, DP; Liin, SI; Larsson HP
Published in: Elife, Issue Jun 23, 2023, Page(s) e85773, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.85773

Pharmacological Screening of Kv7.1 and Kv7.1/KCNE1 Activators as Potential Antiarrhythmic Drugs in the Zebrafish Heart

Author(s): De la Cruz, A; Wu, X; Rainer, QC; Hiniesto-Iñigo, I; Perez ME; Edler, I; Liin, SI; Larsson, HP
Published in: International journal of molecular sciences, Issue 24(15), 2023, Page(s) 12092, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms241512092

Subtype-specific modulation of human KV7 channels by theanticonvulsant cannabidiol through a lipid-exposedpore-domain site

Author(s): Pökl, M; Sridhar, A; Frampton, DFA; Linhart, VA; Delemotte, L; Liin, SI
Published in: British Journal of Pharmacology, Issue Jun 28, 2023, Page(s) 16183, ISSN 0007-1188
Publisher: Wiley-Blackwell
DOI: 10.1111/bph.16183

Faradaic Pixels for Precise Hydrogen Peroxide Delivery toControl M-Type Voltage-Gated Potassium Channels

Author(s): Oliya S. Abdullaeva, Ihor Sahalianov, Malin Silverå Ejneby, Marie Jakešová, Igor Zozoulenko, Sara I. Liin, and Eric Daniel Głowacki
Published in: Advanced Science, Issue 21983844, 2022, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202103132

Polyunsaturated Fatty Acids as Modulators of KV7 Channels

Author(s): Johan E. Larsson, Damon J. A. Frampton, Sara I. Liin
Published in: Frontiers in Physiology, Issue 11, 2020, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.00641

Identification of PUFA interaction sites on the cardiac potassium channel KCNQ1

Author(s): Samira Yazdi, Johan Nikesjö, Williams Miranda, Valentina Corradi, D. Peter Tieleman, Sergei Yu. Noskov, H. Peter Larsson, Sara I. Liin
Published in: Journal of General Physiology, Issue 153/6, 2021, ISSN 0022-1295
Publisher: Rockefeller University Press
DOI: 10.1085/jgp.202012850

Docosahexaenoic acid normalizes QT interval in long QT type 2 transgenic rabbit models in a genotype-specific fashion

Author(s): Alessandro Castiglione, Tibor Hornyik, Eike M Wülfers, Lucilla Giammarino, Iask Edler, Jessica J Jowais, Marina Rieder, Stefanie Perez-Feliz, Gideon Koren, Zsuzsanna Bősze, András Varró, Manfred Zehender, Michael Brunner, Christoph Bode, Sara I. Liin, Hans Peter Larsson, István Baczkó, Katja E Odening
Published in: Europace, Issue 15322092, 2022, ISSN 1532-2092
Publisher: Oxford University Press
DOI: 10.1093/europace/euab228

Mechanistic understanding of KCNQ1 activating polyunsaturated fatty acid analogs

Author(s): Jowais, JJ; Yazdi, S; Golluscio, A; Olivier-Meo, V; Liin, SI; Larsson, HP
Published in: Journal of general physiology, Issue 155(10), 2023, Page(s) e202313339, ISSN 1540-7748
Publisher: Rockefeller University Press
DOI: 10.1085/jgp.202313339

Long-QT mutations in KCNE1 modulate the 17β-estradiol response of Kv7.1/KCNE1

Author(s): Lisa-Marie Erlandsdotter, Lucilla Giammarino, Azemine Halili, Johan Nikesjö, Henrik Gréen, Katja E Odening, Sara I Liin
Published in: Science Advances, 2023, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.ade7109

Endocannabinoids enhance hKV7.1/KCNE1 channel function and shorten the cardiac action potential and QT interval

Author(s): Irene Hiniesto-Iñigo, Laura M Castro-Gonzalez, Valentina Corradi, Mark A Skarsfeldt, Samira Yazdi, Siri Lundholm, Johan Nikesjö, Sergei Yu Noskov, Bo Hjorth Bentzen, D Peter Tieleman, Sara I Liin
Published in: Lancet eBioMedicine, 2023, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2023.104459

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