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Using hidden genealogical structure to study the architecture of human disease

Project description

Increasing statistical power of genome-wide studies for understanding human diseases

In human genetics, a genome-wide association study usually investigates links between single-nucleotide polymorphism and heritable traits, including predisposition to major diseases. However, the impact of rare genetic variants is poorly understood and current available data and analytical tools are not sufficient to study this class of variation. The goal of the EU-funded ARGPHENO project is to develop new computational methods for evaluation of the phenotypic traits of rare genetic variations. The project will focus on methods for accurate reconstruction of genealogy using sequencing data for subsequent identification of rare genetic variants and their hereditary traits and cross-association with common genetic variants.

Host institution

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Net EU contribution
€ 1 499 665,00
Address
Wellington Square University Offices
OX1 2JD Oxford
United Kingdom

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Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Beneficiaries (1)

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Net EU contribution
€ 1 499 665,00
Address
Wellington Square University Offices
OX1 2JD Oxford

See on map

Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00