Project description
Increasing statistical power of genome-wide studies for understanding human diseases
In human genetics, a genome-wide association study usually investigates links between single-nucleotide polymorphism and heritable traits, including predisposition to major diseases. However, the impact of rare genetic variants is poorly understood and current available data and analytical tools are not sufficient to study this class of variation. The goal of the EU-funded ARGPHENO project is to develop new computational methods for evaluation of the phenotypic traits of rare genetic variations. The project will focus on methods for accurate reconstruction of genealogy using sequencing data for subsequent identification of rare genetic variants and their hereditary traits and cross-association with common genetic variants.
Fields of science
Programme(s)
Topic(s)
Funding Scheme
ERC-STG - Starting Grant
Host institution
OX1 2JD Oxford
United Kingdom
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Beneficiaries (1)
OX1 2JD Oxford
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