Single-cell analysis of intestinal lymphocytes reveals targets for treatment of inflammatory bowel disease

Project Information

GUT-SEQ

Grant agreement ID: 850963

DOI 10.3030/850963

EC signature date 30 January 2020

Start date 1 September 2020

End date 31 August 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 500 000,00

EU contribution € 1 500 000,00

Coordinated by

KAROLINSKA INSTITUTET
Sweden

Publications

Peer reviewed articles (3)

The single-cell transcriptional landscape of innate and adaptive lymphocytes in pediatric-onset colitis

Author(s): Efthymia Kokkinou Whitney Weigel Jenny Mjösberg
Published in: Cell Rep Med, Issue 16; 4(5), 2023, Page(s) 101038, ISSN 2666-3791
Publisher: CellPress
DOI: 10.1016/j.xcrm.2023.101038

CD45RA+CD62L- ILCs in human tissues represent a quiescent local reservoir for the generation of differentiated ILCs

Author(s): Kokkinou E, Pandey RV, Mazzurana L, Gutierrez-Perez I, Tibbitt CA, Weigel W, Soini T, Carrasco A, Rao A, Nagasawa M, Bal SM, Jangard M, Friberg D, Lindforss U, Nordenvall C, Ljunggren M, Haapaniemi S, Keita ÅV, Söderholm J, Hedin C, Spits H, Bryceson YT, Mjösberg J.
Published in: Science Immunology, Issue 2022 Apr 15;7(70):eabj8301, 2022, ISSN 2470-9468
Publisher: Science
DOI: 10.1126/sciimmunol.abj8301

Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing.

Author(s): Mazzurana L, Czarnewski P, Jonsson V, Wigge L, Ringnér M, Williams TC, Ravindran A, Björklund ÅK, Säfholm J, Nilsson G, Dahlén SE, Orre AC, Al-Ameri M, Höög C, Hedin C, Szczegielniak S, Almer S, Mjösberg J.
Published in: Cell Research, Issue 2021 May;31(5), 2021, Page(s) 554-568, ISSN 1748-7838
Publisher: Nature
DOI: 10.1038/s41422-020-00445-x