Elucidating the Molecular Mechanism of Myoblast Fusion in Vertebrates

Project Information

MYOCLEM

Grant agreement ID: 851080

DOI

10.3030/851080

Project closed

EC signature date 10 October 2019

Start date 1 November 2019

End date 31 October 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

WEIZMANN INSTITUTE OF SCIENCE
Israel

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (10)

Extracellular vesicle fusion visualized by cryo-electron microscopy

Author(s): Mattia I Morandi; Petro Busko; Efrat Ozer-Partuk; Suman Khan; Giulia Zarfati; Yael Elbaz-Alon; Paula Abou Karam; Tina Napso Shogan; Lana Ginini; Ziv Gil; Neta Regev-Rudzki; Ori Avinoam
Published in: PNAS NEXUS, 2022, ISSN 2752-6542
Publisher: Oxford University Press
DOI: 10.1093/pnasnexus/pgac156

Machine learning inference of continuous single-cell state transitions during myoblast differentiation and fusion

Author(s): Amit Shakarchy, Giulia Zarfati, Adi Hazak, Reut Mealem, Karina Huk, Tamar Ziv, Ori Avinoam, Assaf Zaritsky
Published in: Molecular Systems Biology, 2024, ISSN 1460-2075
Publisher: EMBO Press
DOI: 10.1101/2023.02.19.529100

Fusion pore dynamics of large secretory vesicles define a distinct mechanism of exocytosis

Author(s): Tom Biton, Nadav Scher, Shari Carmon, Yael Elbaz-Alon, Eyal D. Schejter, Ben-Zion Shilo, Ori Avinoam
Published in: Journal of Cell Biology, 2023, ISSN 1540-8140
Publisher: Rockefeller University Press
DOI: 10.1101/2023.06.08.544180

Ca ²⁺ as a coordinator of skeletal muscle differentiation, fusion and contraction

Author(s): Yael Elbaz-Alon; Sansrity Sinha; Ori Avinoam
Published in: FEBS, 2022, ISSN 1742-464X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/febs.16552

ERK1/2 inhibition promotes robust myotube growth via CaMKII activation resulting in myoblast-to-myotube fusion

Author(s): Tamar Eigler, Giulia Zarfati, Emmanuel Amzallag, Sansrity Sinha, Nadav Segev, Yishaia Zabary, Assaf Zaritsky, Avraham Shakked, Kfir-Baruch Umansky, Eyal D. Schejter, Douglas P. Millay, Eldad Tzahor, Ori Avinoam
Published in: Developmental Cell, 2022, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2021.11.022.

Sample preparation and image registration for correlative cryo-FM and cryo-FIB-SEM of plunge-frozen mammalian cells

Author(s): Nadav Scher, Katya Rechav, Perrine Paul-Gilloteaux, Ori Avinoam
Published in: STAR Protocols, 2022, ISSN 2666-1667
Publisher: Cell Press
DOI: 10.1016/j.xpro.2022.101142

In situ fiducial markers for 3D correlative cryo-fluorescence and FIB-SEM imaging

Author(s): Nadav Scher, Katya Rechav, Perrine Paul-Gilloteaux, Ori Avinoam
Published in: iScience, 2021, ISSN 2589-0042
Publisher: Cell Press
DOI: 10.1016/j.isci.2021.102714

Structured RhoGEF recruitment drives myosin II organization on large exocytic vesicles

Author(s): Kumari Kamalesh, Dagan Segal, Ori Avinoam, Eyal D. Schejter, Ben-Zion Shilo
Published in: Journal of Cell Science, Issue 137, 2024, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jcs.261944

High-throughput screening identifies broad-spectrum Coronavirus entry inhibitors

Author(s): Suman Khan, Efrat Ozer Partuk, Jeanne Chiaravalli, Noga Kozer, Khriesto A. Shurrush, Yael Elbaz-Alon, Nadav Scher, Emilie Giraud, Jaouen Tran-Rajau, Fabrice Agou, Haim Michael Barr, Ori Avinoam
Published in: iScience, Issue 27, 2024, Page(s) 110019, ISSN 2589-0042
Publisher: Elsevier
DOI: 10.1016/j.isci.2024.110019

Exocytosis by vesicle crumpling maintains apical membrane homeostasis during exocrine secretion

Author(s): Kumari Kamalesh, Nadav Scher, Tom Biton, Eyal D. Schejter, Ben-Zion Shilo, Ori Avinoam
Published in: Developmental Cell, 2021, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2021.05.004.

Book chapters (1)

Synchronization to Visualization: Dissecting Myogenesis and Regeneration Using Correlative Light and Electron Microscopy (CLEM)

Author(s): Suman Khan, Nadav Scher, Ori Avinoam
Published in: Reference Series in Biomedical Engineering, Bioimaging in Tissue Engineering and Regeneration, 2024, Page(s) 1-16
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-85569-7_5-1