Project description
Ready-made neuronal cell assays for drug testing
Induced pluripotent stem cells (iPSCs) are derived through the reprogramming of adult somatic cells using specific pluripotency factors. They constitute a powerful tool to model human diseases as well as produce rare or difficult-to-grow cell types. The EU-funded COMMER-CELL project is harnessing the results of the FETOPEN MESO-BRAIN project to develop and commercialise 2D and 3D neural co-cultures. Such co-cultures are known for maintaining neuronal functionality and successfully serving as models for Alzheimer’s disease. The goal of COMMER-CELL is to supply these cell models for drug testing applications as well as for investigation into conditions of the central nervous system.
Objective
Development of various human stem cell derived cell types will be carried out to see the completion of the FETOPEN MESO-BRAIN project. Based on immortal pluripotent stem cells (iPSCs), FETOPEN MESO-BRAIN will see the development of techniques for growth of a variety of neural cell types. This provides a unique opportunity for the creation of a marketable product stemming from already intended work. Co-cultured in vitro cell models have the capacity to retain neuronal maturity and functionality for long time periods. Such co-cultures, featuring only two or three different cell types have already been demonstrated as effective models for researching the mechanisms of conditions such as Alzheimer’s disease, indicating consistent and reproducible results. As such, complex and consistently reproducible ready-made co-cultures could be easily directed towards pharmaceutical and biotech companies seeking to use iPSC-derived cells as a basis for building cell-based assays and drug screening based on the validated cells.
As the FETOPEN MESO-BRAIN project already intends to grow major neuronal cell types, complex, physiologically relevant 2D and 3D co-cultures featuring cortical neurones, astrocytes, interneurons and microglia can be developed within COMMER-CELL and made available for sale. Creation and mass-availability of a 4-cell-type co-culture in an easy-to-use and premade form could not only allow for improved research into CNS-affecting conditions and drug testing, but also expedite such research by circumventing the need for research institutions and industrial organisation to create their own time-consuming cell models.
The proposed COMMER-CELL project harnesses results from MESO-BRAIN to deliver concrete added value by raising the technological maturity of the cells to demonstrator level. The fulfilment of the proposition, based upon anticipated positive feedback from the market, will lead to the commercialisation of an innovation derived from FETOPEN MESO-BRAIN.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology dementia alzheimer
- medical and health sciences medical biotechnology cells technologies stem cells
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET)
MAIN PROGRAMME
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H2020-EU.1.2.1. - FET Open
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
CSA - Coordination and support action
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-FETOPEN-2018-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
CB10 1XL Cambridge
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.