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Rational Engineering of Synthetic Systems for Propagation of Information via Catalytic Assembly of Copies

Project description

Engineering basic system for copying information polymer template

The central dogma of molecular biology states that information is directionally transferred from a nucleotide sequence of DNA into a sequence of synthesised RNA and then into a sequence of amino acids in the protein. Many structural aspects of this whole machinery were studied in detail, but we do not understand basic principles of reliable directional copying of polymer templates and were not able to build a simple synthetic copying system. The EU-funded RESSPICAC project will explore minimal models of copying applying principles of thermodynamics of small fluctuating systems and the thermodynamics of information processing to elucidate these principles. The research is going to translate this knowledge into the construction of minimal copying systems using non-biological synthetic DNA, providing insights into analogous processes in living organisms.

Call for proposal

ERC-2019-STG
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Host institution

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 499 433

Beneficiaries (1)

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 1 499 433
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments