Rational Engineering of Synthetic Systems for Propagation of Information via Catalytic Assembly of Copies

Project Information

RESSPICAC

Grant agreement ID: 851910

DOI

10.3030/851910

Project closed

EC signature date 30 October 2019

Start date 1 November 2019

End date 31 December 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 433,00

EU contribution

€ 1 499 433,00

Coordinated by

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan

Develop a Data Management Plan (DMP) to help provide open access to research data

Publications

Peer reviewed articles (11)

Thermodynamic limits in far-from-equilibrium molecular templating networks

Author(s): Benjamin Qureshi, Jenny M. Poulton, Thomas E. Ouldridge
Published in: Newton, Issue 2, 2026, Page(s) 100302, ISSN 2950-6360
Publisher: Elsevier BV
DOI: 10.1016/j.newton.2025.100302

A universal method for analyzing copolymer growth

Author(s): Benjamin Qureshi, Jordan Juritz, Jenny M. Poulton, Adrian Beersing-Vasquez, Thomas E. Ouldridge
Published in: The Journal of Chemical Physics, Issue 158, 2023, Page(s) 104906, ISSN 0021-9606
Publisher: American Institute of Physics
DOI: 10.1063/5.0133489

Kinetic Proofreading Can Enhance Specificity in a Nonenzymatic DNA Strand Displacement Network

Author(s): Rakesh Mukherjee, Aditya Sengar, Javier Cabello-García, Thomas E. Ouldridge
Published in: Journal of the American Chemical Society, Issue 146, 2024, Page(s) 18916-18926, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.3c14673

The interplay of heterogeneity and product detachment in templated polymer copying

Author(s): Jeremy E. B. Guntoro, Benjamin J. Qureshi, Thomas E. Ouldridge
Published in: The Journal of Chemical Physics, Issue 162, 2025, ISSN 0021-9606
Publisher: American Institute of Physics
DOI: 10.1063/5.0245687

Minimal mechanism for cyclic templating of length-controlled copolymers under isothermal conditions

Author(s): Jordan Juritz; Jenny M. Poulton; Thomas E. Ouldridge
Published in: Journal of Chemical Physics, Issue 156, 2022, Page(s) 074103, ISSN 0021-9606
Publisher: American Institute of Physics
DOI: 10.1063/5.0077865

Overcoming the Speed Limit of Four-Way DNA Branch Migration with Bulges in Toeholds

Author(s): Samia Bakhtawar, Francesca Smith, Aditya Sengar, Guy-Bart V. Stan, John Goertz, Molly Stevens, Thomas E. Ouldridge, Wooli Bae
Published in: Nano Letters, Issue 25, 2025, Page(s) 13772-13779, ISSN 1530-6984
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.5c03063

Information propagation through enzyme-free catalytic templating of DNA dimerization with weak product inhibition

Author(s): Javier Cabello-Garcia, Rakesh Mukherjee, Wooli Bae, Guy-Bart V. Stan, Thomas E. Ouldridge
Published in: Nature Chemistry, Issue 17, 2025, Page(s) 1179-1187, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-025-01831-x

Design of DNA strand displacement reactions

Author(s): Križan Jurinović, Merry Mitra, Rakesh Mukherjee, Thomas E Ouldridge
Published in: Current Opinion in Biotechnology, Issue 97, 2026, Page(s) 103396, ISSN 0958-1669
Publisher: Elsevier BV
DOI: 10.1016/j.copbio.2025.103396

Handhold-Mediated Strand Displacement: A Nucleic Acid Based Mechanism for Generating Far-from-Equilibrium Assemblies through Templated Reactions

Author(s): Javier Cabello-Garcia, Wooli Bae, Guy-Bart V. Stan, Thomas E. Ouldridge
Published in: ACS Nano, Issue 15/2, 2021, Page(s) 3272-3283, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.0c10068

Recurrent neural chemical reaction networks that approximate arbitrary dynamics

Author(s): Dack, Alexander; Qureshi, Benjamin; Ouldridge, Thomas E.; Plesa, Tomislav
Published in: Cell Systems, Issue in press, 2026, ISSN 2405-4720
Publisher: Elsevier
DOI: 10.48550/arxiv.2406.03456

A Primer on the oxDNA Model of DNA: When to Use it, How to Simulate it and How to Interpret the Results

Author(s): A. Sengar, T. E. Ouldridge, O. Henrich, L. Rovigatti, P. Šulc
Published in: Frontiers in Molecular Biosciences, Issue 8, 2021, ISSN 2296-889X
Publisher: Frontiers
DOI: 10.3389/fmolb.2021.693710

Non-peer reviewed articles (1)

Setting a direction for molecular recognition

Author(s): Thomas E. Ouldridge, Rakesh Mukherjee
Published in: Nature Nanotechnology, Issue 20, 2025, Page(s) 1359-1360, ISSN 1748-3387
Publisher: Nature Publishing Group
DOI: 10.1038/s41565-025-01997-y