Overcoming cellular barriers to therapeutic RNA delivery using extracellular vesicles

Project Information

OBSERVE

Grant agreement ID: 851936

DOI

10.3030/851936

Project closed

EC signature date 14 January 2020

Start date 1 February 2020

End date 31 January 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (7)

Incorporation of cellular membrane protein extracts into lipid nanoparticles enhances their cellular uptake and mRNA delivery efficiency

Author(s): Diego A. Rodríguez, Gaspard P.R. Lefebvre, Qiangbing Yang, Arjan D. Barendrecht, Cor W. Seinen, Raymond M. Schiffelers, Pieter Vader
Published in: Journal of Controlled Release, Issue 382, 2025, Page(s) 113676, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2025.113676

A call for the standardised reporting of factors affecting the exogenous loading of extracellular vesicles with therapeutic cargos.

Author(s): Stephanie Rankin-Turner; Pieter Vader; Lorraine O'Driscoll; Bernd Giebel; Liam M. Heaney; Owen G Davies
Published in: Advanced Drug Delivery Reviews, Issue 1, 2021, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2021.04.012

Extracellular Vesicle-Based Hybrid Systems for Advanced Drug Delivery

Author(s): Diego A. Rodríguez; Pieter Vader
Published in: Crossref, Issue 2, 2022, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14020267

Integrin beta 1 and fibronectin mediate extracellular vesicle uptake and functional RNA delivery

Author(s): Omnia M. Elsharkasy, Willemijn S. de Voogt, Maria Laura Tognoli, Leanne van der Werff, Jerney J. Gitz-Francois, Cornelis W. Seinen, Raymond M. Schiffelers, Olivier G. de Jong, Pieter Vader
Published in: Journal of Biological Chemistry, Issue 301, 2025, Page(s) 108305, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2025.108305

Extracellular Vesicle-Associated Proteins in Tissue Repair

Author(s): Marieke T. Roefs, Joost P.G. Sluijter, Pieter Vader
Published in: Trends in Cell Biology, Issue 30/12, 2020, Page(s) 990-1013, ISSN 0962-8924
Publisher: Elsevier BV
DOI: 10.1016/j.tcb.2020.09.009

Illuminating RNA trafficking and functional delivery by extracellular vesicles

Author(s): Willemijn S. de Voogt, Marvin E. Tanenbaum, Pieter Vader
Published in: Advanced Drug Delivery Reviews, Issue 174, 2021, Page(s) 250-264, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2021.04.017

Lack of involvement of CD63 and CD9 tetraspanins in the extracellular vesicle content delivery process

Author(s): Maria Laura Tognoli, Julia Dancourt, Emeline Bonsergent, Roberta Palmulli, Olivier G. de Jong, Guillaume Van Niel, Eric Rubinstein, Pieter Vader, Gregory Lavieu
Published in: Communications Biology, Issue 6, 2023, ISSN 2399-3642
Publisher: Nature Portfolio
DOI: 10.1038/s42003-023-04911-1