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A synthetic biology approach for T cell exhaustion

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A call for caution in analysing mammalian co-transfection experiments and implications of resource competition in data misinterpretation.

Author(s): Di Blasi R, Marbiah M, Siciliano V, Polizzi K, Ceroni F
Published in: Nature Communications, 20411723, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-22795-9

Characterization and mitigation of gene expression burden in mammalian cells

Author(s): Timothy Frei, Federica Cella, Fabiana Tedeschi, Joaquín Gutiérrez, Guy-Bart Stan, Mustafa Khammash, Velia Siciliano
Published in: Nature Communications, 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-18392-x

gDesigner: computational design of synthetic gRNAs for Cas12a-based transcriptional repression in mammalian cells

Author(s): Crone M, Mac Donald J, Freemont P, Siciliano V.
Published in: NPJ Systems Biology and Applications, 20567189, 2022, ISSN 2056-7189
Publisher: Nature publishing group
DOI: 10.1038/s41540-022-00241-w