A call for caution in analysing mammalian co-transfection experiments and implications of resource competition in data misinterpretation.
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Autores:
Di Blasi R, Marbiah M, Siciliano V, Polizzi K, Ceroni F
Publicado en:
Nature Communications, Edición 20411723, 2021, ISSN 2041-1723
Editor:
Nature Publishing Group
DOI:
10.1038/s41467-021-22795-9
Characterization and mitigation of gene expression burden in mammalian cells
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Autores:
Timothy Frei, Federica Cella, Fabiana Tedeschi, Joaquín Gutiérrez, Guy-Bart Stan, Mustafa Khammash, Velia Siciliano
Publicado en:
Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor:
Nature Publishing Group
DOI:
10.1038/s41467-020-18392-x
gDesigner: computational design of synthetic gRNAs for Cas12a-based transcriptional repression in mammalian cells
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Autores:
Crone M, Mac Donald J, Freemont P, Siciliano V.
Publicado en:
NPJ Systems Biology and Applications, Edición 20567189, 2022, ISSN 2056-7189
Editor:
Nature publishing group
DOI:
10.1038/s41540-022-00241-w
MIRELLA: a mathematical model explains the effect of microRNA-mediated synthetic genes regulation on intracellular resource allocation
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Autores:
Federica Cella, Giansimone Perrino, Fabiana Tedeschi, Gabriella Viero, Carla Bosia, Guy-Bart Stan, Velia Siciliano
Publicado en:
Nucleic Acids Research, Edición 51, 2023, Página(s) 3452-3464, ISSN 0305-1048
Editor:
Oxford University Press
DOI:
10.1093/nar/gkad151
