A platform for rapidly mapping the molecular and systemic dynamics of aging

Project Information

SYSAGING

Grant agreement ID: 852201

DOI

10.3030/852201

Project closed

EC signature date 8 October 2019

Start date 1 January 2020

End date 30 June 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 981,00

EU contribution

€ 1 499 981,00

Coordinated by

FUNDACIO CENTRE DE REGULACIO GENOMICA
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan (DMP)

The DMP will explain a. the handling of research data during & after the end of the project b. what data will be collected, processed and/or generated c. which methodology & standards will be applied d. whether data will be shared/made open access and e. how data will be curated & preserved (including after the end of the project).

Publications

Other (4)

STOMP-seq: early multiplexing for high-throughput Smart-seq2 RNA-sequencing

Author(s): Matthias Eder, Nicholas Stroustrup
Published in: bioRxiv, Issue 2025, 2025
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.03.28.645277

Intergenerational control of ribosomes under dietary restriction

Author(s): Sigma Pradhan, Klement Stojanovski, Joel Tuomaala, Nicholas Stroustrup, Benjamin D. Towbin
Published in: bioRxiv, Issue 2025, 2025
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.03.01.640961

Selective autophagy of ribosomes balances a tradeoff between starvation survival and growth resumption

Author(s): Joel Tuomaala, Devanarayanan Siva Sankar, Julie Perey, Sacha Psalmon, Nicholas Stroustrup, Joern Dengjel, Benjamin D. Towbin
Published in: bioRxiv, Issue 2024, 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.08.28.609383

Engineering the auxin-inducible degron system for tunable<i>in vivo</i>control of organismal physiology

Author(s): Jeremy Vicencio, Daisuke Chihara, Matthias Eder, Julie Ahringer, Nicholas Stroustrup
Published in: bioRxiv, Issue 2024, 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.09.05.611487

Peer reviewed articles (8)

Neuronal temperature perception induces specific defenses that enable C. elegans to cope with the enhanced reactivity of hydrogen peroxide at high temperature

Author(s): Francesco A Servello; Rute Fernandes; Matthias Eder; Nathan Harris; Olivier MF Martin; Natasha Oswal; Anders Lindberg; Nohelly Derosiers; Piali Sengupta; Nicholas Stroustrup; Javier Apfeld
Published in: Elife, Issue 2022 Oct 13;11:e78941, 2022, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.78941

A hierarchical process model links behavioral aging and lifespan in C. elegans

Author(s): Natasha Oswal; Olivier M. F. Martin; Sofia Stroustrup; Monika Anna Matusiak Bruckner; Nicholas Stroustrup
Published in: PloS Computational Biology, 2022, ISSN 1553-7358
Publisher: PLOS
DOI: 10.1371/journal.pcbi.1010415

Systematic mapping of organism-scale gene-regulatory networks in aging using population asynchrony

Author(s): Matthias Eder, Olivier M.F. Martin, Natasha Oswal, Lucia Sedlackova, Cátia Moutinho, Andrea Del Carmen-Fabregat, Simon Menendez Bravo, Arnau Sebé-Pedrós, Holger Heyn, Nicholas Stroustrup
Published in: Cell, Issue 187, 2025, Page(s) 3919-3935.e19, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2024.05.050

Fasting shapes chromatin architecture through an mTOR/RNA Pol I axis

Author(s): Nada Al-Refaie, Francesco Padovani, Johanna Hornung, Lorenz Pudelko, Francesca Binando, Andrea del Carmen Fabregat, Qiuxia Zhao, Benjamin D. Towbin, Elif Sarinay Cenik, Nicholas Stroustrup, Jan Padeken, Kurt M. Schmoller, Daphne S. Cabianca
Published in: Nature Cell Biology, Issue 26, 2024, Page(s) 1903-1917, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-024-01512-w

Omnipose: a high-precision morphology-independent solution for bacterial cell segmentation

Author(s): Kevin J. Cutler, Carsen Stringer, Teresa W. Lo, Luca Rappez, Nicholas Stroustrup, S. Brook Peterson, Paul A. Wiggins, Joseph D. Mougous
Published in: Nature Methods, Issue 19, 2022, Page(s) 1438–1448, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/s41592-022-01639-4

Similarities and differences in the gene expression signatures of physiological age versus future lifespan

Author(s): Matthew C. Mosley, Holly E. Kinser, Olivier M. F. Martin, Nicholas Stroustrup, Tim Schedl, Kerry Kornfeld, Zachary Pincus
Published in: Aging Cell, Issue 24, 2025, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acel.14428

A complex systems approach to aging biology

Author(s): Alan A. Cohen, Luigi Ferrucci, Tamàs Fülöp, Dominique Gravel, Nan Hao, Andres Kriete, Morgan E. Levine, Lewis A. Lipsitz, Marcel G. M. Olde Rikkert, Andrew Rutenberg, Nicholas Stroustrup, Ravi Varadhan
Published in: Nature Aging, Issue 2, 2022, Page(s) 580–591, ISSN 2662-8465
Publisher: Nature Publishing Group
DOI: 10.1038/s43587-022-00252-6

Caenorhabditis elegans processes sensory information to choose between freeloading and self-defense strategies

Author(s): Jodie A Schiffer, Francesco A Servello, William R Heath, Francis Raj Gandhi Amrit, Stephanie V Stumbur, Matthias Eder, Olivier MF Martin, Sean B Johnsen, Julian A Stanley, Hannah Tam, Sarah J Brennan, Natalie G McGowan, Abigail L Vogelaar, Yuyan Xu, William T Serkin, Arjumand Ghazi, Nicholas Stroustrup, Javier Apfeld
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.56186