Molecular origin of aging
Complex human diseases and ageing begin with slow changes that involve a large number of genes. Preventive medicine is therefore difficult to implement. To study the origins of late-life diseases, a multi-dimensional analysis of molecular changes and physiological parameters during ageing is required. SYSAGING proposes to use C. elegans as a model of a small but fast-growing and aging animal to analyse the molecular origins of complex diseases. Automated microscopy and an image processing platform will be integrated with transcriptomic profiling and in vivo biosensors to collect data at the molecular, cellular, individual and population levels to map factors that increase disease risks. This project will help identify the potential targets for preventive medicine at the molecular and physiological level.
Fields of science
Funding SchemeERC-STG - Starting Grant