Prevention of childhood Acute Lymphoblastic Leukemia immunology links oncology

Project Information

PreventALL

Grant agreement ID: 852222

DOI

10.3030/852222

EC signature date 20 February 2020

Start date 1 July 2020

End date 30 June 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 498 925,00

EU contribution

€ 1 498 925,00

Coordinated by

KLINIKUM DER TECHNISCHEN UNIVERSITÄT MÜNCHEN (TUM KLINIKUM)
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (13)

Clinical and immunophenotypic characteristics of familial leukemia predisposition caused by PAX5 germline variants

Author(s): Adela Escudero, Masatoshi Takagi, Franziska Auer, Ulrike Anne Friedrich, Satoshi Miyamoto, Atsushi Ogawa, Kohsuke Imai, Barbara Pascual, María Vela, Polina Stepensky, Layal Yasin, Sarah Elitzur, Arndt Borkhardt, Antonio Pérez-Martínez, Julia Hauer
Published in: Leukemia, Issue 36, 2022, Page(s) 2338-2342, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/s41375-022-01661-7

Regional BCG vaccination policy in former East- and West Germany may impact on both severity of SARS-CoV-2 and incidence of childhood leukemia

Author(s): Julia Hauer; Ute Fischer; Franziska Auer; Arndt Borkhardt
Published in: Leukemia, Issue 34, 2020, Page(s) 2217–2219, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/s41375-020-0871-4

Germline POT1 Deregulation Can Predispose to Myeloid Malignancies in Childhood

Author(s): Pia Michler; Anne Schedel; Martha Witschas; Ulrike Anne Friedrich; Rabea Wagener; Juha Mehtonen; Triantafyllia Brozou; Maria Menzel; Carolin Walter; Dalileh Nabi; Glen Pearce; Miriam Erlacher; Gudrun Göhring; Martin Dugas; Merja Heinäniemi; Arndt Borkhardt; Friedrich Stölzel; Julia Hauer; Franziska Auer
Published in: International Journal of Molecular Sciences, Issue Volume 22, Issue 21, 2021, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390//ijms222111572

Multicomponent Synthesis, Binding Mode, and Structure−ActivityRelationship of Selective Histone Deacetylase 6 (HDAC6) Inhibitorswith Bifurcated Capping Groups

Author(s): Nina Reßing, Melf Sönnichsen, Jeremy D. Osko, Andrea Schöler, Julian Schliehe-Diecks, Alexander Skerhut, Arndt Borkhardt, Julia Hauer, Matthias U. Kassack, David. W. Christianson, Sanil Bhatia and Finn K. Hansen
Published in: Journal of Medicanial Chemistry, Issue 63 (18), 2020, Page(s) 10339-10351, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.9b01888

Co-targeting HSP90 alpha and CDK7 overcomes resistance against HSP90 inhibitors in BCR-ABL1+ leukemia cells

Author(s): Melina Vogt, Niklas Dienstbier, Julian Schliehe-Diecks, Katerina Scharov, Jia-Wey Tu, Philip Gebing, Julian Hogenkamp, Berna-Selin Bilen, Silke Furlan, Daniel Picard, Marc Remke, Layal Yasin, David Bickel, Munishikha Kalia, Alfredo Iacoangeli, Thomas Lenz, Kai Stühler, Aleksandra A. Pandyra, Julia Hauer, Ute Fischer, Rabea Wagener, Arndt Borkhardt, Sanil Bhatia
Published in: Cell Death & Disease, Issue 14, 2023, ISSN 2041-4889
Publisher: Nature Publishing Group
DOI: 10.1038/s41419-023-06337-3

Toward prevention of childhood ALL by early-life immune training

Author(s): Julia Hauer; Ute Fischer; Arndt Borkhardt
Published in: blood, Issue Volume 138, Issue 16, 2021, Page(s) 1412-1428, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2020009895

Recurrent Germline Variant in RAD21 Predisposes Children to Lymphoblastic Leukemia or Lymphoma

Author(s): Anne Schedel, Ulrike Anne Friedrich, Mina N F Morcos, Rabea Wagener, Juha Mehtonen, Titus Watrin, Claudia Saitta, Triantafyllia Brozou, Pia Michler, Carolin Walter, Asta Försti, Arka Baksi, Maria Menzel, Peter Horak, Nagarajan Paramasivam, Grazia Fazio, Robert J Autry, Stefan Fröhling, Meinolf Suttorp, Christoph Gertzen, Holger Gohlke, Sanil Bhatia, Karin Wadt, Kjeld Schmiegelow, Martin Dugas, D
Published in: International Journal of Molecular Sciences, Issue 23(9), 2022, Page(s) 5174, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23095174

Cytokine Hyperresponsiveness in Children With ETV6::RUNX1-positive Acute Lymphoblastic Leukemia After Challenge With Common Pathogens

Author(s): Nadine Rüchel, Marina Oldenburg, Stefan Janssen, Aleksandra A Pandyra, Wei Liu, Eleni Vasileiou, Daniel Hein, Vera Helena Jepsen, Ute Fischer, Daniel Picard, Gesine Kögler, Julia Hauer, Franziska Auer, Angelina Beer, Ortwin Adams, Colin MacKenzie, Martin Jaeger, Mihai G Netea, Arndt Borkhardt, Katharina L Gössling
Published in: Hemasphere, Issue 7(2), 2023, Page(s) e835, ISSN 2572-9241
Publisher: Wolters Kluwer Health, Inc.
DOI: 10.1097/hs9.0000000000000835

Comprehensive germline-genomic and clinical profiling in 160 unselected children and adolescents with cancer

Author(s): Rabea Wagener, Julia Taeubner, Carolin Walter, Layal Yasin, Deya Alzoubi, Christoph Bartenhagen, Andishe Attarbaschi, Carl-Friedrich Classen, Udo Kontny, Julia Hauer, Ute Fischer, Martin Dugas, Michaela Kuhlen, Arndt Borkhardt, Triantafyllia Brozou
Published in: European Journal of Human Genetics, Issue 29, 2021, Page(s) 1301-1311, ISSN 1018-4813
Publisher: Natue Publishing Group
DOI: 10.1038/s41431-021-00878-x

An intact gut microbiome protects genetically predisposed mice against leukemia

Author(s): Carolina Vicente-Dueñas, Stefan Janssen, Marina Oldenburg, Franziska Auer, Inés González-Herrero, Ana Casado-García, Marta Isidro-Hernández, Javier Raboso-Gallego, Philipp Westhoff, Aleksandra A. Pandyra, Daniel Hein, Katharina L. Gössling, Diego Alonso-López, Javier De Las Rivas, Sanil Bhatia, Francisco Javier García-Criado, María Begoña García-Cenador, Andreas P. M. Weber, Karl Köhre
Published in: Blood, Issue Volume 136, Issue 18, 2021, Page(s) 2003-2017, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2019004381

Development of a First-in-Class Small-Molecule Inhibitor of the C-Terminal Hsp90 Dimerization

Author(s): Sanil Bhatia, Lukas Spanier, David Bickel, Niklas Dienstbier, Vitalij Woloschin, Melina Vogt, Henrik Pols, Beate Lungerich, Jens Reiners, Narges Aghaallaei, Daniela Diedrich, Benedikt Frieg, Julian Schliehe-Diecks, Bertan Bopp, Franziska Lang, Mohanraj Gopalswamy, Jennifer Loschwitz, Baubak Bajohgli, Julia Skokowa, Arndt Borkhardt, Julia Hauer, Finn K Hansen, Sander H J Smits, Joachim Jose, Holger
Published in: ACS Central Science, Issue 8 (5), 2022, Page(s) 636−655, ISSN 2374-7943
Publisher: ACS Publications
DOI: 10.1021/acscentsci.2c00013

A clinical screening tool to detect genetic cancer predisposition in pediatric oncology shows high sensitivity but can miss a substantial percentage of affected children

Author(s): Ulrike A. Friedrich, Marc Bienias, Claudia Zinke, Maria Prazenicova, Judith Lohse, Arne Jahn, Maria Menzel, Jonas Langanke, Carolin Walter, Rabea Wagener, Triantafyllia Brozou, Julian Varghese, Martin Dugas, Miriam Erlacher, Evelin Schröck, Meinolf Suttorp, Arndt Borkhardt, Julia Hauer, Franziska Auer
Published in: Genetics in Medicine, Issue 25, 2023, Page(s) 100875, ISSN 1098-3600
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1016/j.gim.2023.100875

Hyperdiploid acute lymphoblastic leukemia in children with <i>LZTR1</i> germline variants

Author(s): Lisa Zipper, Rabea Wagener, Ute Fischer, Anna Hoffmann, Layal Yasin, Danielle Brandes, Stavrieta Soura, Ammarah Anwar, Carolin Walter, Julian Varghese, Julia Hauer, Franziska Auer, Sanil Bhatia, Martin Dugas, Stefanie V. Junk, Martin Stanulla, Oskar A. Haas, Arndt Borkhardt, Tobias Reiff, Triantafyllia Brozou
Published in: HemaSphere, Issue 8, 2025, ISSN 2572-9241
Publisher: Hemasphere
DOI: 10.1002/hem3.26