Prevention of childhood Acute Lymphoblastic Leukemia immunology links oncology

Información del proyecto

PreventALL

Identificador del acuerdo de subvención: 852222

DOI

10.3030/852222

Fecha de la firma de la CE 20 Febrero 2020

Fecha de inicio 1 Julio 2020

Fecha de finalización 30 Junio 2026

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 498 925,00

Aportación de la UE

€ 1 498 925,00

Coordinado por

KLINIKUM DER TECHNISCHEN UNIVERSITÄT MÜNCHEN (TUM KLINIKUM)
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (13)

Clinical and immunophenotypic characteristics of familial leukemia predisposition caused by PAX5 germline variants

Autores: Adela Escudero, Masatoshi Takagi, Franziska Auer, Ulrike Anne Friedrich, Satoshi Miyamoto, Atsushi Ogawa, Kohsuke Imai, Barbara Pascual, María Vela, Polina Stepensky, Layal Yasin, Sarah Elitzur, Arndt Borkhardt, Antonio Pérez-Martínez, Julia Hauer
Publicado en: Leukemia, Edición 36, 2022, Página(s) 2338-2342, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/s41375-022-01661-7

Regional BCG vaccination policy in former East- and West Germany may impact on both severity of SARS-CoV-2 and incidence of childhood leukemia

Autores: Julia Hauer; Ute Fischer; Franziska Auer; Arndt Borkhardt
Publicado en: Leukemia, Edición 34, 2020, Página(s) 2217–2219, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/s41375-020-0871-4

Germline POT1 Deregulation Can Predispose to Myeloid Malignancies in Childhood

Autores: Pia Michler; Anne Schedel; Martha Witschas; Ulrike Anne Friedrich; Rabea Wagener; Juha Mehtonen; Triantafyllia Brozou; Maria Menzel; Carolin Walter; Dalileh Nabi; Glen Pearce; Miriam Erlacher; Gudrun Göhring; Martin Dugas; Merja Heinäniemi; Arndt Borkhardt; Friedrich Stölzel; Julia Hauer; Franziska Auer
Publicado en: International Journal of Molecular Sciences, Edición Volume 22, Edición 21, 2021, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390//ijms222111572

Multicomponent Synthesis, Binding Mode, and Structure−ActivityRelationship of Selective Histone Deacetylase 6 (HDAC6) Inhibitorswith Bifurcated Capping Groups

Autores: Nina Reßing, Melf Sönnichsen, Jeremy D. Osko, Andrea Schöler, Julian Schliehe-Diecks, Alexander Skerhut, Arndt Borkhardt, Julia Hauer, Matthias U. Kassack, David. W. Christianson, Sanil Bhatia and Finn K. Hansen
Publicado en: Journal of Medicanial Chemistry, Edición 63 (18), 2020, Página(s) 10339-10351, ISSN 0022-2623
Editor: American Chemical Society
DOI: 10.1021/acs.jmedchem.9b01888

Co-targeting HSP90 alpha and CDK7 overcomes resistance against HSP90 inhibitors in BCR-ABL1+ leukemia cells

Autores: Melina Vogt, Niklas Dienstbier, Julian Schliehe-Diecks, Katerina Scharov, Jia-Wey Tu, Philip Gebing, Julian Hogenkamp, Berna-Selin Bilen, Silke Furlan, Daniel Picard, Marc Remke, Layal Yasin, David Bickel, Munishikha Kalia, Alfredo Iacoangeli, Thomas Lenz, Kai Stühler, Aleksandra A. Pandyra, Julia Hauer, Ute Fischer, Rabea Wagener, Arndt Borkhardt, Sanil Bhatia
Publicado en: Cell Death & Disease, Edición 14, 2023, ISSN 2041-4889
Editor: Nature Publishing Group
DOI: 10.1038/s41419-023-06337-3

Toward prevention of childhood ALL by early-life immune training

Autores: Julia Hauer; Ute Fischer; Arndt Borkhardt
Publicado en: blood, Edición Volume 138, Edición 16, 2021, Página(s) 1412-1428, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood.2020009895

Recurrent Germline Variant in RAD21 Predisposes Children to Lymphoblastic Leukemia or Lymphoma

Autores: Anne Schedel, Ulrike Anne Friedrich, Mina N F Morcos, Rabea Wagener, Juha Mehtonen, Titus Watrin, Claudia Saitta, Triantafyllia Brozou, Pia Michler, Carolin Walter, Asta Försti, Arka Baksi, Maria Menzel, Peter Horak, Nagarajan Paramasivam, Grazia Fazio, Robert J Autry, Stefan Fröhling, Meinolf Suttorp, Christoph Gertzen, Holger Gohlke, Sanil Bhatia, Karin Wadt, Kjeld Schmiegelow, Martin Dugas, D
Publicado en: International Journal of Molecular Sciences, Edición 23(9), 2022, Página(s) 5174, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23095174

Cytokine Hyperresponsiveness in Children With ETV6::RUNX1-positive Acute Lymphoblastic Leukemia After Challenge With Common Pathogens

Autores: Nadine Rüchel, Marina Oldenburg, Stefan Janssen, Aleksandra A Pandyra, Wei Liu, Eleni Vasileiou, Daniel Hein, Vera Helena Jepsen, Ute Fischer, Daniel Picard, Gesine Kögler, Julia Hauer, Franziska Auer, Angelina Beer, Ortwin Adams, Colin MacKenzie, Martin Jaeger, Mihai G Netea, Arndt Borkhardt, Katharina L Gössling
Publicado en: Hemasphere, Edición 7(2), 2023, Página(s) e835, ISSN 2572-9241
Editor: Wolters Kluwer Health, Inc.
DOI: 10.1097/hs9.0000000000000835

Comprehensive germline-genomic and clinical profiling in 160 unselected children and adolescents with cancer

Autores: Rabea Wagener, Julia Taeubner, Carolin Walter, Layal Yasin, Deya Alzoubi, Christoph Bartenhagen, Andishe Attarbaschi, Carl-Friedrich Classen, Udo Kontny, Julia Hauer, Ute Fischer, Martin Dugas, Michaela Kuhlen, Arndt Borkhardt, Triantafyllia Brozou
Publicado en: European Journal of Human Genetics, Edición 29, 2021, Página(s) 1301-1311, ISSN 1018-4813
Editor: Natue Publishing Group
DOI: 10.1038/s41431-021-00878-x

An intact gut microbiome protects genetically predisposed mice against leukemia

Autores: Carolina Vicente-Dueñas, Stefan Janssen, Marina Oldenburg, Franziska Auer, Inés González-Herrero, Ana Casado-García, Marta Isidro-Hernández, Javier Raboso-Gallego, Philipp Westhoff, Aleksandra A. Pandyra, Daniel Hein, Katharina L. Gössling, Diego Alonso-López, Javier De Las Rivas, Sanil Bhatia, Francisco Javier García-Criado, María Begoña García-Cenador, Andreas P. M. Weber, Karl Köhre
Publicado en: Blood, Edición Volume 136, Edición 18, 2021, Página(s) 2003-2017, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood.2019004381

Development of a First-in-Class Small-Molecule Inhibitor of the C-Terminal Hsp90 Dimerization

Autores: Sanil Bhatia, Lukas Spanier, David Bickel, Niklas Dienstbier, Vitalij Woloschin, Melina Vogt, Henrik Pols, Beate Lungerich, Jens Reiners, Narges Aghaallaei, Daniela Diedrich, Benedikt Frieg, Julian Schliehe-Diecks, Bertan Bopp, Franziska Lang, Mohanraj Gopalswamy, Jennifer Loschwitz, Baubak Bajohgli, Julia Skokowa, Arndt Borkhardt, Julia Hauer, Finn K Hansen, Sander H J Smits, Joachim Jose, Holger
Publicado en: ACS Central Science, Edición 8 (5), 2022, Página(s) 636−655, ISSN 2374-7943
Editor: ACS Publications
DOI: 10.1021/acscentsci.2c00013

A clinical screening tool to detect genetic cancer predisposition in pediatric oncology shows high sensitivity but can miss a substantial percentage of affected children

Autores: Ulrike A. Friedrich, Marc Bienias, Claudia Zinke, Maria Prazenicova, Judith Lohse, Arne Jahn, Maria Menzel, Jonas Langanke, Carolin Walter, Rabea Wagener, Triantafyllia Brozou, Julian Varghese, Martin Dugas, Miriam Erlacher, Evelin Schröck, Meinolf Suttorp, Arndt Borkhardt, Julia Hauer, Franziska Auer
Publicado en: Genetics in Medicine, Edición 25, 2023, Página(s) 100875, ISSN 1098-3600
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1016/j.gim.2023.100875

Hyperdiploid acute lymphoblastic leukemia in children with <i>LZTR1</i> germline variants

Autores: Lisa Zipper, Rabea Wagener, Ute Fischer, Anna Hoffmann, Layal Yasin, Danielle Brandes, Stavrieta Soura, Ammarah Anwar, Carolin Walter, Julian Varghese, Julia Hauer, Franziska Auer, Sanil Bhatia, Martin Dugas, Stefanie V. Junk, Martin Stanulla, Oskar A. Haas, Arndt Borkhardt, Tobias Reiff, Triantafyllia Brozou
Publicado en: HemaSphere, Edición 8, 2025, ISSN 2572-9241
Editor: Hemasphere
DOI: 10.1002/hem3.26