Project description
A commoner trumps nobility when it comes to catalysing change
Organic compounds are characterised by the presence of carbon, which forms the 'backbone' of molecules in living organisms. Long carbon chains are also critical to polymer chemistry, as many polymers are derived from fossil fuels. Nature has provided an immense library of organic compounds with innumerable roles, and there are virtually limitless possibilities for new ones. However, to unlock that potential, novel reaction pathways must lead to innovative products while lowering financial and energy costs. The EU-funded DoReMI project has set out to develop new synthetic strategies to catalyse carbon-carbon bond formation using iron as an inexpensive and eco-friendly alternative to noble metals. Outcomes could open the door to a new era of discovery with applications in numerous fields.
Objective
Due to the ubiquity of the C-C bond in diverse areas such as pharmaceuticals, agrochemicals or materials, development of atom-economical and efficient methods ensuring its formation is an active research field. This field witnessed incredible breakthroughs during the last decades, especially thanks to organometallic catalysis applied to cross-coupling or C-H activation methods. However, the most efficient C-C bond formation reactions rely on noble-metal catalysts, which lead to economic and toxicity issues. Iron catalysis appears as a promising alternative, since this metal is cheap and environmentally-friendly. Yet, current methods of Fe-mediated C-C bond formation suffer from strong scope limitations and lead to processes with a poor atom economy, as they often require stoichiometric organometallics or sacrificial reactants (metalation reagents, or oxidants). Dominating the reactivity of the C-Fe bond is pivotal to address those issues, since organoiron derivatives are key intermediates in Fe-mediated C-C bond formations. This reactivity is rich and complex, and is governed both by redox and spin effects. The DoReMI project aims to use this complexity as an advantage to develop new synthetic strategies, which cannot be envisioned with noble metal catalysis, aiming at overtaking the aforementioned pitfalls. In a first work package (WP1), the mechanistic features of the reaction of organoirons with electrophiles will be unveiled, shedding light on the reactivity of the C-Fe bond in a C-C bond formation context. WP2 will show for the first time that a stoichiometric C-H functionalization reaction between non-activated hydrocarbons and electrophiles can be achieved via the formation of an organoiron intermediate. Using the results gathered in WP1 and WP2, WP3 will demonstrate that this C-H functionalization methodology can be turned into an efficient catalytic method applicable to both unfunctionalized C-H substrates and to targets of synthetic interest.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- natural sciences chemical sciences organic chemistry hydrocarbons
- natural sciences chemical sciences catalysis
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-STG - Starting Grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2019-STG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.