A lifelong transcatheter aortic valve prosthesis

Project Information

TAVI4Life

Grant agreement ID: 852814

DOI

10.3030/852814

Project closed

EC signature date 4 March 2020

Start date 1 October 2020

End date 31 March 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 375,00

EU contribution

€ 1 499 375,00

Coordinated by

UNIVERSITAT ZURICH
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (16)

Development of an iPSC-derived tissue-resident macrophage-based platform for the in vitro immunocompatibility assessment of human tissue engineered matrices

Author(s): Nikolaos Poulis, Marcy Martin, Simon P. Hoerstrup, Maximilian Y. Emmert, Emanuela S. Fioretta
Published in: Scientific Reports, Issue 14, 2024, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-024-62745-1

Computational modelling to reduce outcome variability in tissue-engineered heart valves

Author(s): Valery L Visser, Polina Zaytseva, Sarah E Motta, Sandra Loerakker, Simon P Hoerstrup, Maximilian Y Emmert
Published in: European Heart Journal, 2021, ISSN 1522-9645
Publisher: Oxford Academic
DOI: 10.1093/eurheartj/ehab034

Endothelial Progenitor Cell-Based in vitro Pre-Endothelialization of Human Cell-Derived Biomimetic Regenerative Matrices for Next-Generation Transcatheter Heart Valves Applications

Author(s): Sarah E. Motta, Polina Zaytseva, Emanuela S. Fioretta, Valentina Lintas, Christian Breymann, Simon P. Hoerstrup, and Maximilian Y. Emmert
Published in: Frontiers in Bioengineering and Biotechnology, 2022, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2022.867877

Human iPSCs and Genome Editing Technologies for Precision Cardiovascular Tissue Engineering

Author(s): Eric K. N. Gähwiler, Sarah E. Motta, Marcy Martin, Bramasta Nugraha, Simon P. Hoerstrup, and Maximilian Y. Emmert
Published in: Frontiers in Cell and Developmental Biology, 2021, ISSN 2296-634X
Publisher: Frontiers
DOI: 10.3389/fcell.2021.639699

Smooth leaflets with curved belly and attachment edge profiles promote adaptive remodeling in tissue-engineered heart valves: an in silico study

Author(s): Valery L. Visser, Sarah E. Motta, Simon P. Hoerstrup, Frank P. T. Baaijens, Sandra Loerakker, Maximilian Y. Emmert
Published in: Biomechanics and Modeling in Mechanobiology, Issue 24, 2025, Page(s) 811-828, ISSN 1617-7959
Publisher: Springer Verlag
DOI: 10.1007/s10237-025-01937-8

Tissue engineered heart valves for transcatheter aortic valve implantation: current state, challenges, and future developments

Author(s): Nikolaos Poulis, Polina Zaytseva, Eric K. N. Gähwiler, Sarah E. Motta, Emanuela S. Fioretta, Nikola Cesarovic, Volkmar Falk, Simon P. Hoerstrup, and Maximilian Y. Emmert
Published in: Expert Review of Cardiovascular Therapy, 2020, ISSN 1744-8344
Publisher: London Future Drugs 2003-
DOI: 10.1080/14779072.2020.1792777

Apoptosis as a strategy for enhancing decellularization and remodeling of tissue-engineered heart valves

Author(s): Pascal Breitenstein, Marcy Martin, Valery L. Visser, Sarah E. Motta, Maximilian Y. Emmert, Melanie Generali, Simon P. Hoerstrup
Published in: Biomaterials, Issue 327, 2025, Page(s) 123765, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2025.123765

Polymeric valves appearing on the transcatheter horizon

Author(s): Sarah E Motta, Volkmar Falk, Simon P Hoerstrup, Maximilian Y Emmert
Published in: European Journal of Cardio-Thoracic Surgery, 2021, ISSN 1873-734X
Publisher: Oxford Academic
DOI: 10.1093/ejcts/ezab089

Macrophage-extracellular matrix interactions: Perspectives for tissue engineered heart valve remodeling

Author(s): Poulis, Nikolaos; Martin, Marcy; Hoerstrup, Simon P.; Emmert, Maximilian Y.; Fioretta, Emanuela S.
Published in: Frontiers in Cardiovascular Medicine, 9, Issue 2, 2022
Publisher: Frontiers
DOI: 10.3389/fcvm.2022.952178

Geometry influences inflammatory host cell response and remodeling in tissue-engineered heart valves in-vivo

Author(s): Sarah E. Motta, Emanuela S. Fioretta, Valentina Lintas, Petra E. Dijkman, Monika Hilbe, Laura Frese, Nikola Cesarovic, Sandra Loerakker, Frank P. T. Baaijens, Volkmar Falk, Simon P. Hoerstrup & Maximilian Y. Emmert
Published in: Scientific Reports, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-76322-9

Endothelial Progenitor Cell-Based in vitro Pre-Endothelialization of Human Cell-Derived Biomimetic Regenerative Matrices for Next-Generation Transcatheter Heart Valves Applications

Author(s): Motta, Sarah E; Zaytseva, Polina; Fioretta, Emanuela S; Lintas, Valentina; Breymann, Christian; Hoerstrup, Simon P; Emmert, Maximilian Y
Published in: Frontiers in Bioengineering and Biotechnology, 10, Issue 1, 2022
Publisher: Frontiers
DOI: 10.3929/ethz-b-000543977

Combining Cell Technologies With Biomimetic Tissue Engineering Applications: A New Paradigm for Translational Cardiovascular Therapies

Author(s): Sarah E Motta; Marcy Martin; Eric K N Gähwiler; Valery L Visser; Polina Zaytseva; Arian Ehterami; Simon P Hoerstrup; Maximilian Y Emmert
Published in: Stem Cells Translational Medicine, 12 (2), Issue 1, 2023, ISSN 2157-6580
Publisher: Oxford University Press
DOI: 10.1093/stcltm/szad002

Combining genome and tissue engineering for next-generation human biomimetics

Author(s): Eric K N Gähwiler, Valery L Visser, Melanie Generali, Dennis Zorndt, Darcie R Jackson, Maximilian Y Emmert, Simon P Hoerstrup, Marcy Martin
Published in: Stem Cells Translational Medicine, Issue 14, 2025, ISSN 2157-6564
Publisher: AlphaMed Press
DOI: 10.1093/stcltm/szaf048

Geometry influences inflammatory host cell response and remodeling in tissue-engineered heart valves in-vivo.

Author(s): Sarah E. Motta; Emanuela S. Fioretta; Valentina Lintas; Petra E. Dijkman; Monika Hilbe; Laura Frese; Nikola Cesarovic; S Sandra Loerakker; Frank P. T. Baaijens; Volkmar Falk; Volkmar Falk; Simon P. Hoerstrup; Maximilian Y. Emmert
Published in: Scientific Reports, 10 (1), Issue 1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.3929/ethz-b-000452305

Next-generation tissue-engineered heart valves with repair, remodelling and regeneration capacity

Author(s): Emanuela S. Fioretta, Sarah E. Motta, Valentina Lintas, Sandra Loerakker, Kevin K. Parker, Frank P. T. Baaijens, Volkmar Falk, Simon P. Hoerstrup & Maximilian Y. Emmert
Published in: Nature Reviews Cardiology, 2021, ISSN 1759-5010
Publisher: Nature Portfolio
DOI: 10.1038/s41569-020-0422-8

Multiscale analysis of human tissue engineered matrices for next generation heart valve applications

Author(s): N. Poulis; P. Breitenstein; S. Hofstede; S.P. Hoerstrup; M.Y. Emmert; E.S. Fioretta
Published in: Acta Biomaterialia, 158, Issue 1, 2023, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.3929/ethz-b-000600392