Project description
Molecular mechanisms of cell self-defence
Many pathogens have the ability to escape the immune system by invading the host cells and hiding inside phagosomes whose membrane prevents pathogen recognition and elimination. Cell-autonomous immunity represents the part of the cell self-defence system that fights off such pathogens. This immune response mobilises the guanylate-binding proteins that form dynamic supramolecular complexes promoting lysis of phagosomes and elimination of pathogens. The goal of the EU-funded PHAGOSCOPY project is to study molecular mechanisms of this immune response, and to obtain detailed information about the composition of the guanylate-binding protein complex and its rearrangements leading to rupture of the phagosome membrane. The research will employ a novel approach for integrative imaging involving cryo-electron microscopy and fluorescence microscopy in combination with a unique native phagosome ex vivo reconstitution system.
Field of science
- /medical and health sciences/health sciences/public and environmental health/epidemics prevention/immunisation
- /natural sciences/biological sciences/biochemistry/biomolecules/proteins
- /natural sciences/biological sciences/molecular biology/structural biology
- /medical and health sciences/basic medicine/immunology
Topic(s)
Call for proposal
ERC-2019-STG
See other projects for this call
Funding Scheme
ERC-STG - Starting GrantHost institution
2628 CN Delft
Netherlands
Beneficiaries (1)
2628 CN Delft