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Metabolic Coupling During Bacterial Development

Project description

Metabolic regulation of differentiation in bacteria

Bacterial endospores (a.k.a. spores) are highly resilient cell types that some species form to survive extreme conditions. Spore formation involves the collaboration between two cells: the forespore, which becomes the resilient spore, and the mother cell, which dies after sporulation. This project will explore the role housekeeping metabolism, required for a cell to function normally, in sporulation. To achieve this goal, the researcher will perform a genome-wide study of the role of housekeeping genes during sporulation, taking advantage of a system that allows the inactivation of individual housekeeping functions in the mother cell or the forespore. This study may find out if mother cell and forespore depend on each other and what factors play a critical role in their differentiation.

Call for proposal

ERC-2019-STG
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Host institution

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Address
Hofgartenstrasse 8
80539 Munchen
Germany
Activity type
Research Organisations
EU contribution
€ 1 500 000

Beneficiaries (1)

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 1 500 000
Address
Hofgartenstrasse 8
80539 Munchen
Activity type
Research Organisations