Metabolic regulation of differentiation in bacteria
Bacterial endospores (a.k.a. spores) are highly resilient cell types that some species form to survive extreme conditions. Spore formation involves the collaboration between two cells: the forespore, which becomes the resilient spore, and the mother cell, which dies after sporulation. This project will explore the role housekeeping metabolism, required for a cell to function normally, in sporulation. To achieve this goal, the researcher will perform a genome-wide study of the role of housekeeping genes during sporulation, taking advantage of a system that allows the inactivation of individual housekeeping functions in the mother cell or the forespore. This study may find out if mother cell and forespore depend on each other and what factors play a critical role in their differentiation.
Fields of science
Call for proposal
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Funding SchemeERC-STG - Starting Grant