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Progress new assets (one pre-new molecular entity and one first-time-in-human start) for tuberculosis that act synergistically with bedaquiline, cytochrome bc or cytochrome bd inhibitors

Project description

Novel drug combination treatment for tuberculosis

Tuberculosis (TB) is still the world's most deadly infectious disease, and multidrug-resistant TB poses a serious threat to global health. Treatment options are limited and often associated with many adverse effects from the drugs. The overall objective of the EU-funded RespiriTB project is to find new drug candidates for efficient combination treatment against TB and multidrug-resistant TB. The drug combination will target the energy metabolism of Mycobacterium tuberculosis (Mtb), using recently discovered inhibitors of the Mtb respiratory pathway. It will also target host factors that are essential for the intracellular survival of Mtb. The project presents a comprehensive plan to find novel strategies to combat TB, shorten treatment time and reduce incidences of drug resistance.

Call for proposal

H2020-JTI-IMI2-2018-16-single-stage
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Coordinator

ACADEMISCH ZIEKENHUIS LEIDEN
Address
Albinusdreef 2
2333 ZA Leiden
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 968 282,50

Participants (8)

UNIVERSITEIT LEIDEN
Netherlands
EU contribution
€ 124 375
Address
Rapenburg 70
2311 EZ Leiden
Activity type
Higher or Secondary Education Establishments
UNIVERSITEIT ANTWERPEN
Belgium
EU contribution
€ 4 179 723,34
Address
Prinsstraat 13
2000 Antwerpen
Activity type
Higher or Secondary Education Establishments
SORBONNE UNIVERSITE
France
EU contribution
€ 343 875
Address
21 Rue De L'ecole De Medecine
75006 Paris
Activity type
Higher or Secondary Education Establishments
MEDIZINISCHE UNIVERSITAET WIEN
Austria
EU contribution
€ 813 125
Address
Spitalgasse 23
1090 Wien
Activity type
Higher or Secondary Education Establishments
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 99 638,53
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
JANSSEN PHARMACEUTICA NV
Belgium
EU contribution
€ 0
Address
Turnhoutseweg 30
2340 Beerse
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MITOLOGICS
France
EU contribution
€ 146 630,63
Address
Avenue Gaston Roussel 102
93230 Romainville
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FFUND BV
Netherlands
EU contribution
€ 164 350
Address
Hollandse Kade 32
1391 JM Abcoude
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)