Livrables
In vitro activity of single HDT compounds report will summarize the results of in vitro activity of single Host Directed Therapeutics compounds against intracellular NTM strains in human cells
Zebrafish in vivo test reportThe Zebrafish in vivo test report will summarize the methodology and results of the efficacy against known tuberculosis compounds and the effect on granuloma testing in zebrafish larvae for individual NTM compounds
Human NTM in vitro infection Model reportThe Human NTM in vitro infection Model report will describe the methodology and assay conditions for an in vitro infection model for NTM (M. avium) in human cells
Purified NTM cytochrome reportThe Purified NTM cytochrome report will describe the methodology and confirmation of the biological structures of the purified cytochrome bc1, bc1:aa3, and bd
NTM drug PK reportNTM drug PK report will describe the methodology used and describe the PK model of the NTM drugs
Enzymatic Assay and Characterization of cyt bc1 & bd inhibitors reportThe Enzymatic Assay and Characterization of cyt bc1 & bd inhibitors report will describe the assay, conditions and characterisation methodology of the enzymatic assay for testing cytochrome bc1 and cytochrome bd inhibitors
The website developped for communication of all RespiriNTM activities will be active and online
Publications
Auteurs:
Gül Kilinç, Anno Saris, Tom H. M. Ottenhoff, Mariëlle C. Haks
Publié dans:
Immunological Reviews, Numéro 01052896, 2021, Page(s) 62-83, ISSN 0105-2896
Éditeur:
Blackwell Publishing Inc.
DOI:
10.1111/imr.12951
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