Clinical assessment of PILA PHARMA’s TRPV1 antagonist, XEN-D0501, as a novel type of oral anti-diabetic agent

Informations projet

XEND

N° de convention de subvention: 856317

DOI

10.3030/856317

Projet clôturé

Date de signature de la CE 23 Janvier 2019

Date de début 1 Février 2019

Date de fin 31 Juillet 2019

Financé au titre de

• INDUSTRIAL LEADERSHIP - Innovation In SMEs

Coût total

€ 71 429,00

Contribution de l’UE

€ 50 000,00

Coordonné par

PILA PHARMA AB
Sweden

Periodic Reporting for period 1 - XEND (Clinical assessment of PILA PHARMA’s TRPV1 antagonist, XEN-D0501, as a novel type of oral anti-diabetic agent)

Période du rapport: 2019-02-01 au 2019-07-31

Résumé du contexte et des objectifs généraux du projet

Diabetes is a group of metabolic diseases in which the person has high blood glucose (blood sugar), either because insulin production is inadequate or one does not produce insulin (known as type 1 diabetes), or because the body's cells do not respond properly to insulin (known as type 2 diabetes), or both. TRPV1 (transient receptor potential vanilloid 1)-antagonists are substances that can temporarily block the activity of the ‘chili-receptor’, TRPV1. TRPV1 has been studied intensively in the area of pain management as a potential target to control chronic pain as a supplement to pain killers. To date, none of the TRPV1 antagonists in clinical development have been assessed for their eventual antidiabetic effects in man.
The overall objectives of this project were to develop and optimize a business plan that will guide the exploitation and commercialization of PILA PHARMA’s compound - XEN-D0501 that has enormous potential to treat type 2 diabetes.

Travail effectué depuis le début du projet jusqu’à la fin de la période considérée dans le rapport et principaux résultats atteints jusqu’à présent

PILA PHARMA performed the feasibility study, which then will guide the overall company business development strategy. It provided a valuable understanding of the current trends and opportunities on the type 2 diabetes market, targeted users, competitive landscape, and potential partnership opportunities. A work plan for carrying out further studies that will evaluate the benefit of our product in type 2 diabetes patients was also developed.
The feasibility study has confirmed that there is a clear business opportunity to exploit the global antidiabetic therapeutics market.

Progrès au-delà de l’état des connaissances et impact potentiel prévu (y compris l’impact socio-économique et les conséquences sociétales plus larges du projet jusqu’à présent)

This feasibility study has confirmed the innovative character of the PILA PHARMA’s approach. We have confirmed that TRPV1 antagonists represent a novel therapeutic approach to treat both type 2 diabetes and its inflammation-related co-morbidities. The co-morbidities of type 2 diabetes, in particular, cardiovascular disease are a leading cause of disability and premature death. According to the European Medicines Agency 1, about half of type 2 diabetes patients need a new drug to maintain adequate glucose control every 3 to 4 years. This necessitates a constant renewal of therapeutic approaches. We are the first company to begin the clinical testing of a TRPV1 antagonist specifically as a treatment for type 2 diabetes. We thrive to validate our promising results further and the potential for a novel antidiabetic drug that will provide optimal therapy and decrease healthcare costs. The problem of diabetes is growing dramatically and PILA PHARMA is assured of the significant impact its innovative approach will have on the diabetes burden in Europe and worldwide.

PILA PHARMA