At the beginning of the project, Prof. Kari Hemminki, Ph.D. was selected as the ERA Chair holder and hired. The Laboratory of Translational Cancer Genomics was established at the Biomedical Center (BC) of the Faculty of Medicine in Pilsen (FMP), Charles University (CUNI), under the leadership of prof. Hemminki. The team of the Laboratory has been assembled, comprising both domestic and internationally recruited researchers. The laboratory acquired several research grants and is working at full capacity, producing original research results and collaborating with colleagues both within and outside of CUNI. The ERA Chair holder familiarized himself with the conditions and procedures at CUNI and works with the CUNI management in key structural areas, providing his feedback and advice in reforming the Ph.D. studies, research evaluation, and career growth opportunities. The ERA Research Club established as a part of the project supplement these efforts by offering numerous educational, collaborative, networking, and counseling events and opportunities to the CUNI staff, especially young researchers and Ph.D. students.