Pan-European twinning to re-establish world-level Neuroscience Centre in Kiev (NEUROTWIN)

Resultado final

Workshops will be centred on transfer of knowledge, methodology and current approaches as well as on developing and documenting research protocols. We shall organize three such workshops during the period of this project. One is in month 3, second is in month 15 (followed by Scientific Writing Workshop), third is in month 27 (followed by Proposal Writing Workshop)

Summer School and Student Workshop

"Student Workshop “Biophysical methods in Neuroscience” annually held in BIPH during last 13 years. In 2020, 2021 and 2022 the Workshop will be held in Aprils at BIPH. The main aim of this event is to promote state-of-the-art methods, which are in use for Neuroscience research for early stage researchers with their future recruiting to PhD Neuroscience programs at BIPH. The school consist of lectures and practical works related to experimental neuroscience. Summer School is an annual project organized by Student Science Association and the National Technical University of Ukraine ""KPI"" in Kiev, Ukraine in close collaboration with the Neuroscience Division of BIPH. The prior aim of the project is to promote science among youth. In the framework of the NEUROTWIN “Neuroscience Stream” of Summer School will be focused on the computational aspects of the field. This school will be held in Mays of 2020,2021 and 2022 "

Policy Makers Meetings

Round tables of Scientific Committee members, high-ranking officers of Ukrainian Ministry of Science and Education, members of Parliament and other policy makers with leaders of Participating teams will be organized during their visits to Kiev.

PGM staff Training Visits

To train the Translational Research Office staff, the staff members will visit the participating EU institutions and relevant EU courses focusing on the commercialisation and translational implementation of advances in basic biomedical research. Two sets of visits are planned in month 5 and 16

USN Congress

Ukrainian Society for Neuroscience (USN) Congress 2020 will be a good platform for disseminating of project results for both scientific and industrial community in Ukraine. Previous USN Congress (2017) has gathered about 150 participants from leading neuroscience-oriented institutions, SMEs and pharmaceutical companies. In order to increase the scientific level of the USN congress 2020 and attract early stage researchers we plan to invite 4 keynote speakers using NEUROTWIN support. We plan to announce 10 travel grants for early stage neuroscience-oriented researchers from remote Ukrainian regions.

Scientific Writing Workshop and Publication Contest

Organization of in-house workshops centred on writing research articles / scientific reports. One workshop per year (months 3, 15, 27), in which members of IBMC, UU, TUM and UCL teams will meet to share their skills in writing research papers with the BIPH scientists. The timetable of these workshops will match that of Knowledge Transfer Workshops to minimize costs. Invited speakers, experts in these fields shall deliver educational talks and arrange practical training.

Proposal Writing Workshops

Organization of three in-house workshops centred on grant proposals writing is planned. One workshop per year (months 3, 15, 27) in which members of ZSI, IBMC, UU, TUM and UCL teams will meet to share their skills in writing grant proposals with the BIP scientists. In addition, invited trainers and experts in the Horizon 2020 structural organization, writing applications and legal and financial grant management will deliver educational talks and arrange practical training.

Science-Industry Workshops

We will organize two Science-Industry Workshops (months 8, 18) involving our major industrial stakeholders from biomedical services and health care institutions in Ukraine and some overseas businesses, to exchange knowledge, ideas, and methods, and to establish solid science-industry relationship.

Seminar room renovation

Training, dissemination and communication during the implementation of the project require a good quality presentation room having installed necessary modern demonstration, communication and recording equipment. The Neuroscience Division of BIPH has its own seminar room that can fit up to 50 people. This room is perfectly suited for the most activities in the framework of the project including lectures, seminars, workshops, communication with legislators, governmental officers and industrial stakeholders. Unfortunately, this room has not been renovated for 25 years. In order to create necessary conditions for training, dissemination and communication we plan to remodel the seminar room and to install in this room modern demonstration, communication and recording equipment (from indirect costs).

Project Factsheets

The Project Factsheets will be permanently filled with announces and relevant results of NEUROTWIN exercises.

Smart Specialization Strategy Recommendations

It is anticipated that the Twinning activity will allow for the first time in Ukraine to develop recommendations for the overall Smart Specialization Strategy of the Kiev region leading to the future creation of general Neuroscience cluster. These recommendations will be based on the interactions of BIPH with local authorities, SME of Kiev region, overseas organizations and research institutions in Ukraine that will be established during the accomplishment of the Project

Peer-reviewed publications of the coordinating entity during the three years preceding the start date of the project

Introduce in the Continuous reporting tool on the Funding and Tenders portal before the end of month 2 of the project peer-reviewed publications (in the particular field of research) of the coordinating entity during the three years preceding the start date of the project.

Key Performance Indicators

"Evolution of the publications in high impact journals in the fields of Cellular and Molecular Neuroscience. This indicator measures the evolution (compared to a reference period of three years prior to the signature of the grant agreement) in % of the peer-reviewed publications in high impact journals (in the top 10% impact ranked journals) in the field of Cellular and Molecular Neuroscience in BIPH under the ""Twinning"" measures."

Grant initiation measures

Protocol of cooperation, Editorial Group, PGM Department, Translational Research Office, CDE Committee, CDE Plan, Educational Committee, Management Committees, Partnership Agreement, Project Website will be created/organised

Video- and Handbooks.

The lectures as well as methods and approaches presented during Workshops will be recorded in video format and saved as VideoBooks-of-Transferable-Training and Handbooks-of-Scientific-Methods-and-Protocols. The Knowledge Transfer Committee will be responsible for editing of these VideoBooks and Handbooks and the PGM Department and Editorial Group will take care of their production.

Publicaciones

Descending control of the spinal lamina X neurons

Autores: Krotov V, Agashkov K, Safronov B, Belan P, Voitenko N.
Publicado en: Society for Neurosciences Meeting proceeding, 2019
Editor: Society for Neurosciences

Changes in the biophysical properties of certain ion channels underlie an inflammation-induced increase in the excitability of pH-sensitive DRG nociceptive neurons

Autores: Duzhyy D, Voitenko N and Belan P.
Publicado en: FENS Virtual Forum Proceedings, 2020
Editor: . FENS

Low threshold-afferent-driven inhibition in superficial dorsal horn neurons

Autores: Andrianov Y, Shevchuk D, Tretiak N, Safronov B, Voitenko N, Belan P.
Publicado en: FENS Virtual Forum proceedings, 2020
Editor: FENS

Nanostructured antagonist of extrasynaptic NMDA receptors improves mice cognitive function after mild traumatic brain injury

Autores: Voitenko N, Pivneva T, Chaika A, Molokanova E, Savtchenko A.
Publicado en: FENS Virtual Forum proceedings, 2020
Editor: FENS

Low threshold-afferent-driven inhibition of spinal lamina I neurons

Autores: Andrianov Y, Shevchuk D, Tretiak N, Safronov B, Voitenko N, Belan P.
Publicado en: Society for Neurosciences Meeting proceeding, 2019
Editor: Society for Neurosciences

Mechanisms of epileptiform activity and properties of hippocampal synaptic plasticity due to dysfunction of the blood-brain barrier. FENS Virtual Forum 2020.

Autores: Savotchenko A, Semenikhina M, Bohovyk R, Fedoriuk M, Isaeva E.
Publicado en: FENS Virtual Forum Proceedings, 2020
Editor: FENS

Calcium-dependent effects of hypoxia-induced synaptic plasticity in the retinocollicular visual pathway

Autores: Dumanskaia H, Veselovsky N.
Publicado en: FENS Virtual Forum Proceedings, 2020
Editor: FENS

Exclusive targeting of extrasynaptic NMDA receptors improves mice cognitive function after mild traumatic brain injury. Society for Neurosciences Meeting, 19-23 October 201 9, Chicago IL, USA

Autores: Chaika A, Pivneva T, Savtchenko A, Molokanova E, Voitenko N.
Publicado en: Society for Neurosciences Meeting proceeding, 2019
Editor: Society for Neurosciences

Presynaptic Ca2+-permeable AMPA-receptors modulate paired-pulse depression in nociceptive sensory synapses

Autores: Shypshyna M.
Publicado en: FENS Virtual Forum Proceedings, 2020
Editor: FENS

Defining pre- and post-synaptic Ca2+ signaling in the spinal cord in pain sensitization

Autores: Keyes A, Warwick C, Shutov L, Krotov V, Belan P, Usachev Y.Keyes A, Warwick C, Shutov L, Krotov V, Belan P, Usachev Y.
Publicado en: Society for Neurosciences Meeting proceeding, 2019
Editor: Society for Neurosciences

Descending regulation of the spinal lamina X neuron functioning

Autores: Krotov V, Agashkov K, Safronov B, Belan P and Voitenko N.
Publicado en: FENS Virtual Forum proceedings, 2020
Editor: FENS

Fluorescence lifetime imaging reveals regulation of presynaptic Ca 2+ by glutamate uptake and mGluRs, but not somatic voltage in cortical neurons

Autores: Olga Tyurikova, Kaiyu Zheng, Elizabeth Nicholson, Yulia Timofeeva, Alexey Semyanov, Kirill E. Volynski, Dmitri A. Rusakov
Publicado en: Journal of Neurochemistry, Edición 156/1, 2021, Página(s) 48-58, ISSN 0022-3042
Editor: Blackwell Publishing Inc.
DOI: 10.1111/jnc.15094

Polylactic Acid-Based Patterned Matrixes for Site-Specific Delivery of Neuropeptides On-Demand: Functional NGF Effects on Human Neuronal Cells

Autores: Olga A. Sindeeva, Olga Kopach, Maxim A. Kurochkin, Andrei Sapelkin, David J. Gould, Dmitri A. Rusakov, Gleb B. Sukhorukov
Publicado en: Frontiers in Bioengineering and Biotechnology, Edición 8, 2020, ISSN 2296-4185
Editor: Froniers
DOI: 10.3389/fbioe.2020.00497

Distinct mechanisms of signal processing by lamina I spino-parabrachial neurons

Autores: K. Agashkov, V. Krotov, M. Krasniakova, D. Shevchuk, Y. Andrianov, Y. Zabenko, B. V. Safronov, N. Voitenko, P. Belan
Publicado en: Scientific Reports, Edición 9/1, 2019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-019-55462-7

LTP Induction Boosts Glutamate Spillover by Driving Withdrawal of Perisynaptic Astroglia

Autores: Christian Henneberger, Lucie Bard, Aude Panatier, James P. Reynolds, Olga Kopach, Nikolay I. Medvedev, Daniel Minge, Michel K. Herde, Stefanie Anders, Igor Kraev, Janosch P. Heller, Sylvain Rama, Kaiyu Zheng, Thomas P. Jensen, Inmaculada Sanchez-Romero, Colin J. Jackson, Harald Janovjak, Ole Petter Ottersen, Erlend Arnulf Nagelhus, Stephane H.R. Oliet, Michael G. Stewart, U. Valentin Nägerl, Dmit
Publicado en: Neuron, Edición 108/5, 2020, Página(s) 919-936.e11, ISSN 0896-6273
Editor: Cell Press
DOI: 10.1016/j.neuron.2020.08.030

TRP Channels as Novel Targets for Endogenous Ligands: Focus on Endocannabinoids and Nociceptive Signalling

Autores: Maksim V. Storozhuk, Alexander V. Zholos
Publicado en: Current Neuropharmacology, Edición 16/2, 2018, ISSN 1570-159X
Editor: Bentham Science Publishers
DOI: 10.2174/1570159x15666170424120802

Short-term hypoxia induces bidirectional pathological long-term plasticity of neurotransmission in visual retinocollicular pathway

Autores: Hanna Dumanska, Nickolai Veselovsky
Publicado en: Experimental Eye Research, Edición 179, 2019, Página(s) 25-31, ISSN 0014-4835
Editor: Academic Press
DOI: 10.1016/j.exer.2018.10.014

Maturation and phenotype of pathophysiological neuronal excitability of human cells in tau-related dementia

Autores: Olga Kopach, Noemí Esteras, Selina Wray, Dmitri A. Rusakov, Andrey Y. Abramov
Publicado en: Journal of Cell Science, Edición 133/10, 2020, Página(s) jcs241687, ISSN 0021-9533
Editor: The Company of Biologists Ltd.
DOI: 10.1242/jcs.241687

Release probability increases towards distal dendrites boosting high-frequency signal transfer in the rodent hippocampus

Autores: Thomas P Jensen, Olga Kopach, James P Reynolds, Leonid P Savtchenko, Dmitri A Rusakov
Publicado en: eLife, Edición 10, 2021, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.62588

Acid-sensing ion channels regulate spontaneous inhibitory activity in the hippocampus: possible implications for epilepsy

Autores: O. Ievglevskyi, D. Isaev, O. Netsyk, A. Romanov, M. Fedoriuk, O. Maximyuk, E. Isaeva, N. Akaike, O. Krishtal
Publicado en: Philosophical Transactions of the Royal Society B: Biological Sciences, Edición 371/1700, 2016, Página(s) 20150431, ISSN 0962-8436
Editor: Royal Society of London
DOI: 10.1098/rstb.2015.0431

Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

Autores: Tianye Jia, Congying Chu, Yun Liu, Jenny van Dongen, Evangelos Papastergios, Nicola J. Armstrong, Mark E. Bastin, Tania Carrillo-Roa, Anouk den Braber, Mathew Harris, Rick Jansen, Jingyu Liu, Michelle Luciano, Anil P. S. Ori, Roberto Roiz Santiañez, Barbara Ruggeri, Daniil Sarkisyan, Jean Shin, Kim Sungeun, Diana Tordesillas Gutiérrez, Dennis van’t Ent, David Ames, Eric Artiges, Georgy Bakalki
Publicado en: Molecular Psychiatry, 2019, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/s41380-019-0605-z

Spinal PKCα inhibition and gene-silencing for pain relief: AMPAR trafficking at the synapses between primary afferents and sensory interneurons

Autores: Olga Kopach, Volodymyr Krotov, Angela Shysh, Andrij Sotnic, Viacheslav Viatchenko-Karpinski, Victor Dosenko, Nana Voitenko
Publicado en: Scientific Reports, Edición 8/1, 2018, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-28512-9

Hindlimb motor responses to unilateral brain injury: spinal cord encoding and left-right asymmetry

Autores: Mengliang Zhang, Hiroyuki Watanabe, Daniil Sarkisyan, Marlene Storm Andersen, Olga Nosova, Vladimir Galatenko, Liliana Carvalho, Nikolay Lukoyanov, Jonas Thelin, Jens Schouenborg, Georgy Bakalkin
Publicado en: Brain Communications, Edición 2/1, 2020, ISSN 2632-1297
Editor: Oxford Academic
DOI: 10.1093/braincomms/fcaa055

Biodegradable Microcapsules Loaded with Nerve Growth Factor Enable Neurite Guidance and Synapse Formation

Autores: Olga Kopach, Anton M. Pavlov, Olga A. Sindeeva, Gleb B. Sukhorukov, Dmitri A. Rusakov
Publicado en: Pharmaceutics, Edición 13/1, 2021, Página(s) 25, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13010025

Genotype-dependent epigenetic regulation of DLGAP2 in alcohol use and dependence

Autores: Weida Meng, Louise K. Sjöholm, Olga Kononenko, Nicole Tay, Dandan Zhang, Daniil Sarkisyan, Jennifer R. Geske, Alex Ing, Wenqing Qiu, Hiroyuki Watanabe, Radwa Almamoun, Helge Frieling, Stefan Bleich, Donghong Cui, Joanna M. Biernacka, R. Dayne Mayfield, Yongjun Dang, Victor M. Karpyak, Gunter Schumann, Georgy Bakalkin, Tomas J. Ekström, Joelle Rüegg, Yun Liu
Publicado en: Molecular Psychiatry, 2019, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/s41380-019-0588-9

Opposite, bidirectional shifts in excitation and inhibition in specific types of dorsal horn interneurons are associated with spasticity and pain post-SCI

Autores: Olga Kopach, Volodymyr Medvediev, Volodymyr Krotov, Anya Borisyuk, Vitaliy Tsymbaliuk, Nana Voitenko
Publicado en: Scientific Reports, Edición 7/1, 2017, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-017-06049-7

Perturbed Ca2+-dependent signaling of DYT2 hippocalcin mutant as mechanism of autosomal recessive dystonia

Autores: D.S. Osypenko, A.V. Dovgan, N.I. Kononenko, A.V. Dromaretsky, M. Matvieienko, O.A. Rybachuk, J. Zhang, S.M. Korogod, V. Venkataraman, P. Belan
Publicado en: Neurobiology of Disease, Edición 132, 2019, Página(s) 104529, ISSN 0969-9961
Editor: Academic Press
DOI: 10.1016/j.nbd.2019.104529

Suppression of mICAT in Mouse Small Intestinal Myocytes by General Anaesthetic Ketamine and its Recovery by TRPC4 Agonist (-)-englerin A

Autores: Mariia I. Melnyk, Dariia O. Dryn, Lina T. Al Kury, Dmytro O. Dziuba, Alexander V. Zholos
Publicado en: Frontiers in Pharmacology, Edición 11, 2020, ISSN 1663-9812
Editor: Frontiers Media S.A.
DOI: 10.3389/fphar.2020.594882

Functional Characterization of Lamina X Neurons in ex-Vivo Spinal Cord Preparation

Autores: Volodymyr Krotov, Anastasia Tokhtamysh, Olga Kopach, Andrew Dromaretsky, Yevhenii Sheremet, Pavel Belan, Nana Voitenko
Publicado en: Frontiers in Cellular Neuroscience, Edición 11, 2017, ISSN 1662-5102
Editor: Frontiers Research Foundation
DOI: 10.3389/fncel.2017.00342

Optimized Model of Cerebral Ischemia In situ for the Long-Lasting Assessment of Hippocampal Cell Death

Autores: Oksana Rybachuk, Olga Kopach, Volodymyr Krotov, Nana Voitenko, Tatyana Pivneva
Publicado en: Frontiers in Neuroscience, Edición 11, 2017, ISSN 1662-453X
Editor: Lausanne: Frontiers Media S.A.
DOI: 10.3389/fnins.2017.00388

Maturation of neural stem cells and integration into hippocampal circuits – a functional study in an in situ model of cerebral ischemia

Autores: Olga Kopach, Oksana Rybachuk, Volodymyr Krotov, Vitalii Kyryk, Nana Voitenko, Tatyana Pivneva
Publicado en: Journal of Cell Science, Edición 131/4, 2018, Página(s) jcs210989, ISSN 0021-9533
Editor: The Company of Biologists Ltd.
DOI: 10.1242/jcs.210989

Optical monitoring of glutamate release at multiple synapses in situ detects changes following LTP induction

Autores: Olga Kopach, Kaiyu Zheng, Dmitri A. Rusakov
Publicado en: Molecular Brain, Edición 13/1, 2020, ISSN 1756-6606
Editor: BioMed Central
DOI: 10.1186/s13041-020-00572-x

A modulatory role of ASICs on GABAergic synapses in rat hippocampal cell cultures

Autores: Maksim Storozhuk, Elena Kondratskaya, Lyudmila Nikolaenko, Oleg Krishtal
Publicado en: Molecular Brain, Edición 9/1, 2016, ISSN 1756-6606
Editor: BioMed Central
DOI: 10.1186/s13041-016-0269-4

Extracellular GABA waves regulate coincidence detection in excitatory circuits

Autores: Sergiy Sylantyev, Leonid P. Savtchenko, Nathanael O'Neill, Dmitri A. Rusakov
Publicado en: The Journal of Physiology, Edición 598/18, 2020, Página(s) 4047-4062, ISSN 0022-3751
Editor: Blackwell Publishing Inc.
DOI: 10.1113/jp279744

Differential suppression of the ipsi- and contralateral nociceptive reflexes in the neonatal rat spinal cord by agonists of µ-, δ- and κ-opioid receptors

Autores: Joana Duarte, Elisabete C. Fernandes, Olga Kononenko, Daniil Sarkisyan, Liliana L. Luz, Georgy Bakalkin, Boris V. Safronov
Publicado en: Brain Research, Edición 1717, 2019, Página(s) 182-189, ISSN 0006-8993
Editor: Elsevier BV
DOI: 10.1016/j.brainres.2019.04.026

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