INnovation in Safety Pharmacology for Integrated cardiovascular safety assessment to REduce adverse events and late stage drug attrition.

Deliverables

Documents, reports (4)

Publications and conference attendance by ESRs (1st report)

A detailed report on all publications and conference attendance by ESRsDuring all communications presentations publciations the EUlogo and the Grant Number will be acknowledgedFirst report M24

Implementation of outreach strategy to the general public

Implementation of outreach strategy to the general publicContinuous effort1st report on M242nd report on M48

First report on (new) MoA of structural/functional cardiotoxicity

First report on new MoA of structuralfunctional cardiotoxicity

Interim Report on engagement of ESRs in outreach to the public

Report on engagement of ESRs in outreach to the publicinterim report on M24 final report on M48

Other (2)

All ESRs recruited, enrolled in PhD training and declarations of conformity signed

All ESRs recruited enrolled in PhD training and declarations of conformity signed

Start recruitment procedure

Start recruitment (advertisements, selection criteria). Positioned advertised and application platform in place

Websites, patent fillings, videos etc. (1)

Promotional materials such as a project website, flyer, semi-annual newsletters, social media posts, etc.

Promotional materials such as a project website, flyer, semi-annual newsletters, social media posts etc. Importantly, reaching this deliverable is just the start of the outreach campaign, afterwards outreach to the general public and the scientific community will be a continuous process; all communication activities will also be listed on the website.

Publications

Peer reviewed articles (7)

Measuring Locomotor Activity and Behavioral Aspects of Rodents Living in the Home-Cage

Author(s): Klein Christian J. M. I., Budiman Thomas, Homberg Judith R., Verma Dilip, Keijer Jaap, van Schothorst Evert M.
Published in: Frontiers in Behavioral Neuroscience, 16, 2022, ISSN 1662-5153
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnbeh.2022.877323

Monitoring haemodynamic changes in rodent models to better inform safety pharmacology: Novel insights from in vivo studies and waveform analysis

Author(s): Marieke Van Daele, Samantha L Cooper, Patrizia Pannucci, Edward S Wragg, Julie March, Iwan de Jong and Jeanette Woolard
Published in: JRSM Cardiovascular Disease, Vol. 11, 2022, Page(s) 1–9, ISSN 2048-0040
Publisher: SAGE Publications Ltd
DOI: 10.1177/20480040221092893

Artificial Neural Network Comparison on hERG Channel Blockade Detection

Author(s): Haibo Liu,Tessa De Korte,Sylvain Bernasconi,Christophe Bleunven,Damiano Lombardi,Muriel Boulakia
Published in: International Journal of Computer Applications, Volume 184 - No.14, 2022, Page(s) 0975 - 8887, ISSN 0975-8887
Publisher: Foundation of Computer Science
DOI: 10.5120/ijca2022922119

Involvement of β- adrenoceptors in the cardiovascular responses induced by selective adenosine A2A and A2B receptor agonists

Author(s): Edward S. Wragg, Patrizia Pannucci, Stephen J. Hill, Jeanette Woolard, Samantha L. Cooper.
Published in: Pharmacology Research & Perspectives, Vol. 10, Issue3, 2022, ISSN 2052-1707
Publisher: Wiley
DOI: 10.1002/prp2.975

Regionally selective cardiovascular responses to adenosine A2A and A2B receptor activation

Author(s): Samantha L. Cooper,Edward S. Wragg,Patrizia Pannucci,Mark Soave,Stephen J. Hill,Jeanette Woolard
Published in: FASEB Journal, Monthly, with an annual supplement, 2022, Page(s) NA, ISSN 0892-6638
Publisher: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202101945r

Doxorubicin induces arterial stiffness: A comprehensive in vivo and ex vivo evaluation of vascular toxicity in mice

Author(s): Matthias Bosman; Kasper Favere; Cédric H.G. Neutel; Griet Jacobs; Guido R.Y. De Meyer; Wim Martinet; Emeline M. Van Craenenbroeck; Pieter-Jan D.F. Guns
Published in: International Journal Molecular Science, 2 - 22(23), 2021, Page(s) 12812, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.1016/j.toxlet.2021.04.015

INSPIRE: A European training network to foster research and training in cardiovascular safety pharmacology

Author(s): Pieter-Jan D. Guns, Brian D. Guth, Stefan Braam, Georgios Kosmidis, Elena Matsa, Annie Delaunois, Vitalina Gryshkova, Sylvain Bernasconi, Harm J. Knot, Yair Shemesh, Alon Chen, Michael Markert, Miguel A. Fernández, Damiano Lombardi, Céline Grandmont, Berta Cillero-Pastor, Ron M.A. Heeren, Wim Martinet, Jeanette Woolard, Matt Skinner, Vincent F.M. Segers, Constantijn Franssen, Emeline M. Van Crae
Published in: Journal of Pharmacological and Toxicological Methods, 105, 2020, Page(s) 106889, ISSN 1056-8719
Publisher: Elsevier BV
DOI: 10.1016/j.vascn.2020.106889

Conference proceedings (1)

Comparison of statistical, machine learning, and mathematical modelling methods to investigate the effect of ageing on dog's cardiovascular system

Author(s): Elham Ataei, Sara Costa Faya, Haibo Liu, Damiano Lombardi, Sylvain Bernasconi, Pieter-Jan Guns, Michael Markert
Published in: ESAIM: PROCEEDINGS AND SURVEYS, Vol. ?, 2023,, 2023, Page(s) 1-10
Publisher: EDP Sciences, SMAI 2023