INnovation in Safety Pharmacology for Integrated cardiovascular safety assessment to REduce adverse events and late stage drug attrition.

Informazioni relative al progetto

INSPIRE

ID dell’accordo di sovvenzione: 858070

DOI

10.3030/858070

Progetto chiuso

Data della firma CE 19 Agosto 2019

Data di avvio 1 Gennaio 2020

Data di completamento 31 Maggio 2024

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 4 021 968,60

Contributo UE

€ 4 021 968,60

Coordinato da

UNIVERSITEIT ANTWERPEN
Belgium

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (9)

Publications and conference attendance by ESRs (1st report)

A detailed report on all publications and conference attendance by ESRsDuring all communications presentations publciations the EUlogo and the Grant Number will be acknowledgedFirst report M24

Final report on engagement of ESRs in outreach to the public

Final report on engagement of ESRs in outreach to the public.(final report on M48, interim report on M24)

Implementation of outreach strategy to the general public

Implementation of outreach strategy to the general publicContinuous effort1st report on M242nd report on M48

First report on (new) MoA of structural/functional cardiotoxicity

First report on new MoA of structuralfunctional cardiotoxicity

Interim Report on engagement of ESRs in outreach to the public

Report on engagement of ESRs in outreach to the publicinterim report on M24 final report on M48

Potential inputs for policy feedback

Consortium should include any relevant information, results, activities who could contribute to any policy development in their domain. This information could then be used for policy feedback purposes.

Publications and conference attendance by ESRs (2nd report)

A detailed report on all publications and conference attendance by ESRs.During all communications (presentations, publciations) the EU-logo and the Grant Number will be acknowledged.First report: M24

Final report on new MoA in cardio-oncology and possible risk mitigation by biomarkers or preventive strategies

Final report on new MoA in cardio-oncology and possible risk mitigation by biomarkers or preventive strategies.

Report on added value of arterial flow/stiffness measures for SP

Report on added value of arterial flow/stiffness measures for SP.

Other (4)

All ESRs recruited, enrolled in PhD training and declarations of conformity signed

All ESRs recruited enrolled in PhD training and declarations of conformity signed

Organisation of the Outreach Conference

Two outrach events will be organised in collaboration with the SPS, respectively at M21 and M45

Start recruitment procedure

Start recruitment (advertisements, selection criteria). Positioned advertised and application platform in place

Awarding PhD degrees to ESRs

Awarding PhD degrees to ESRs.

Websites, patent fillings, videos etc. (1)

Promotional materials such as a project website, flyer, semi-annual newsletters, social media posts, etc.

Promotional materials such as a project website, flyer, semi-annual newsletters, social media posts etc. Importantly, reaching this deliverable is just the start of the outreach campaign, afterwards outreach to the general public and the scientific community will be a continuous process; all communication activities will also be listed on the website.

Pubblicazioni

Peer reviewed articles (19)

Optimization of bioanalysis of dried blood samples

Autori: Elham Ataei Alizadeh, Georg Rast, Chris Cantow, Jessica Schiwon, Florian Krause, Guido R.Y. De Meyer, Pieter-Jan Guns, Brian D. Guth, Michael Markert
Pubblicato in: Journal of Pharmacological and Toxicological Methods, Numero 107296, 2023, ISSN 1056-8719
Editore: Elsevier BV
DOI: 10.1016/j.vascn.2023.107296

Empagliflozin decreases ageing-associated arterial stiffening and vascular fibrosis under normoglycemic conditions

Autori: Cédric H.G. Neutel, Callan D. Wesley, Melissa Van Praet, Celine Civati, Lynn Roth, Guido R.Y. De Meyer, Wim Martinet, Pieter-Jan Guns
Pubblicato in: Vascular Pharmacology, Numero Vol. 152, 107212, 2023, ISSN 1537-1891
Editore: Elsevier BV
DOI: 10.1016/j.vph.2023.107212

Improved on-tissue detection of the anti-cancer agent doxorubicin by quantitative matrix-assisted laser desorption/ionization mass spectrometry imaging

Autori: Charles Van Assche, Dustin Krüger, Bryn Flinders, Michiel Vandenbosch, Constantijn Franssen, Pieter-Jan Guns, Ron M A Heeren, Berta Cillero-Pastor
Pubblicato in: Talanta, Numero Vol. 271, 2024, Pagina/e PMID: 38245959, ISSN 0039-9140
Editore: Elsevier BV
DOI: 10.1016/j.talanta.2024.125667

Measuring Locomotor Activity and Behavioral Aspects of Rodents Living in the Home-Cage

Autori: Klein Christian J. M. I., Budiman Thomas, Homberg Judith R., Verma Dilip, Keijer Jaap, van Schothorst Evert M.
Pubblicato in: Frontiers in Behavioral Neuroscience, Numero 16, 2022, ISSN 1662-5153
Editore: Frontiers Research Foundation
DOI: 10.3389/fnbeh.2022.877323

The effect of cyclic stretch on aortic viscoelasticity and the putative role of smooth muscle focal adhesion

Autori: Cédric H. G. Neutel, Callan D. Wesley, Guido R. Y. De Meyer, Wim Martinet, and Pieter-Jan Guns
Pubblicato in: Frontiers in Physiology, Numero Volume 14 - 2023, 2023, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2023.1218924

Monitoring haemodynamic changes in rodent models to better inform safety pharmacology: Novel insights from in vivo studies and waveform analysis

Autori: Marieke Van Daele, Samantha L Cooper, Patrizia Pannucci, Edward S Wragg, Julie March, Iwan de Jong and Jeanette Woolard
Pubblicato in: JRSM Cardiovascular Disease, Numero Vol. 11, 2022, Pagina/e 1–9, ISSN 2048-0040
Editore: SAGE Publications Ltd
DOI: 10.1177/20480040221092893

Artificial Neural Network Comparison on hERG Channel Blockade Detection

Autori: Haibo Liu,Tessa De Korte,Sylvain Bernasconi,Christophe Bleunven,Damiano Lombardi,Muriel Boulakia
Pubblicato in: International Journal of Computer Applications, Numero Volume 184 - No.14, 2022, Pagina/e 0975 - 8887, ISSN 0975-8887
Editore: Foundation of Computer Science
DOI: 10.5120/ijca2022922119

Role of endothelin ETA receptors in the hypertension induced by the VEGFR-2 kinase inhibitors axitinib and lenvatinib in conscious freely-moving rats

Autori: Patrizia Pannucci, Marieke Van Daele, Samantha L. Cooper, Edward S. Wragg, Julie March, Marleen Groenen, Stephen J. Hill
Pubblicato in: Biochemical Pharmacology, Numero 116007, 2023, ISSN 0006-2952
Editore: Elsevier BV
DOI: 10.1016/j.bcp.2023.116007

Characterization of systolic and diastolic function, alongside proteomic profiling, in doxorubicin-induced cardiovascular toxicity in mice

Autori: Dustin N. Krüger, Matthias Bosman, Charles X.L. Van Assche, Callan D. Wesley, Berta Cillero-Pastor, Leen Delrue, Ward Heggermont, Jozef Bartunek, Guido R. Y. De Meyer, Emeline M. Van Craenenbroeck, Pieter-Jan Guns & Constantijn Franssen
Pubblicato in: Cardio-Oncology, Numero 10, 40 (2024), 2024, ISSN 2057-3804
Editore: BioMed Central Ltd unless otherwise stated. Part of Springer Nature.
DOI: 10.1186/s40959-024-00241-1

Involvement of β- adrenoceptors in the cardiovascular responses induced by selective adenosine A2A and A2B receptor agonists

Autori: Edward S. Wragg, Patrizia Pannucci, Stephen J. Hill, Jeanette Woolard, Samantha L. Cooper.
Pubblicato in: Pharmacology Research & Perspectives, Numero Vol. 10, Numero3, 2022, ISSN 2052-1707
Editore: Wiley
DOI: 10.1002/prp2.975

Doxorubicin impairs smooth muscle cell contraction : novel insights in vascular toxicity

Autori: Bosman Matthias, Kruger Dustin N., Favere Kasper, Wesley Callan D., Neutel Cédric, Van Asbroeck Birgit, Diebels Owen R., Faes Bart, Schenk Timen J., Martinet Wim, De Meyer Guido, van Craenenbroeck Emeline, Guns Pieter-Jan
Pubblicato in: International journal of molecular sciences, Numero 22:23(2021), 12812, 2021, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222312812

Circulating MicroRNA as Biomarkers of Anthracycline-Induced Cardiotoxicity: JACC: CardioOncology State-of-the-Art Review

Autori: Hanne M. Boen, Martina Cherubin, Constantijn Franssen, Andreas B. Gevaert, Isabel Witvrouwen, Matthias Bosman, Pieter-Jan Guns, Hein Heidbuchel, Bart Loeys, Maaike Alaerts, and Emeline M. Van Craenenbroeck
Pubblicato in: Journal of American College of Cardiology Foundation, Numero Vol. 6 No. 2, 2024, Pagina/e 183–199, ISSN 2666-0873
Editore: Published by Elsevier on Behalf of The American College of Cardiology Foundation
DOI: 10.1016/j.jaccao.2023.12.009

Characterisation of tyrosine kinase inhibitor-receptor interactions at VEGFR2 using sunitinib-red and nanoBRET

Autori: Marieke Van Daele, Laura E. Kilpatrick, Jeanette Woolard, Stephen J. Hill
Pubblicato in: Biochemical Pharmacology, Numero Vol. 214, 2023, ISSN 0006-2952
Editore: Elsevier BV
DOI: 10.1016/j.bcp.2023.115672

The impact of environmental and biological factors on the resting heart rate of dogs as assessed using 20 years of data from safety pharmacology studies

Autori: Elham Ataei Alizadeh, Thomas Trautmann, Florian Krause, Benjamin Knoeferl, Pieter-Jan Guns, Guido De Meyer, Brian D. Guth, Michael Markert
Pubblicato in: Journal of Pharmacological and Toxicological Methods, Numero Volume 121, May–June 2023, 107263, 2023, ISSN 1056-8719
Editore: Elsevier BV
DOI: 10.1016/j.vascn.2023.107263

Doxorubicin-induced cardiovascular toxicity: a longitudinal evaluation of functional and molecular markers

Autori: Matthias Bosman, Dustin Krüger, Charles Van Assche, Hanne Boen, Cédric Neutel, Kasper Favere, Constantijn Franssen, Wim Martinet, Lynn Roth, Guido R Y De Meyer, Berta Cillero-Pastor, Leen Delrue, Ward Heggermont, Emeline M Van Craenenbroeck, Pieter-Jan Guns
Pubblicato in: Cardiovascular Research, Numero cvad 136, 2023, Pagina/e 1-12, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvad136

COVID-19-Induced Myocarditis: Pathophysiological Roles of ACE2 and Toll-like Receptors

Autori: Patrizia Pannucci , Sophie R. Jefferson, Jonathan Hampshire, Samantha L. Cooper, Stephen J. Hill, and Jeanette Woolard
Pubblicato in: International Journal Molecular Science 2023, Numero 24(6), 5374, 2023, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24065374

Regionally selective cardiovascular responses to adenosine A2A and A2B receptor activation

Autori: Samantha L. Cooper,Edward S. Wragg,Patrizia Pannucci,Mark Soave,Stephen J. Hill,Jeanette Woolard
Pubblicato in: FASEB Journal, Numero Monthly, with an annual supplement, 2022, Pagina/e NA, ISSN 0892-6638
Editore: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202101945r

Dexrazoxane does not mitigate early vascular toxicity induced by doxorubicin in mice

Autori: Bosman Matthias, Krüger Dustin, Favere Kasper, De Meyer Guido, Franssen Constantijn, van Craenenbroeck Emeline, Guns Pieter-Jan
Pubblicato in: PLoS ONE, Numero 18:11(2023), e0294848, 2023, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0294848

Thirty years of telemetry-based data acquisition for cardiovascular drug safety evaluation: Applications and optimization

Autori: Elham Ataei Alizadeh, Karin Graf, Jessica Schiwon, Thomas Trautmann, Florian Krause, Werner Mayer, Katrin Christ, Eric Martel, Brian D. Guth, Michael Markert
Pubblicato in: Journal of Pharmacological and Toxicological Methods, Numero Vol. 122, July–August 2023, 107279, 2023, ISSN 1056-8719
Editore: Elsevier BV
DOI: 10.1016/j.vascn.2023.107279

Other (1)

Parameter identification through gradient flow on latent variables

Autori: Muriel Boulakia, Haibo Liu, Damiano Lombardi
Pubblicato in: Hal Open Science, 2023
Editore: Hal Open Science

Conference proceedings (1)

Comparison of statistical, machine learning, and mathematical modelling methods to investigate the effect of ageing on dog’s cardiovascular system

Autori: Elham Ataei Alizadeh, Sara Costa Faya, Haibo Liu, Damiano Lombardi, Sylvain Bernasconi, Pieter-Jan Guns and Michael Markert
Pubblicato in: ESAIM: Proceedings and Surveys, Numero Vol. 73, 2023, Pagina/e 2-27, ISSN 2267-3059
Editore: EDP Sciences
DOI: 10.1051/proc/202373002