Project description
Inhibiting cellular 'stickiness' could cure pancreatic and ovarian cancers
Cell adhesion molecules (CAMs) are a class of cell-membrane glycoproteins (proteins with sugar additions) that act like cellular glue. They are involved in functions ranging from maintenance of tissue architecture and cell motility to immunity, as well as signalling. Sometimes, these roles have detrimental effects. For instance, L1CAM is linked to proliferation and metastases in pancreatic and ovarian human cancers. The EU-funded Anti-L1CAM project plans to bring their antibody against L1CAM to market. It has proved efficacious as an anti-cancer therapy in mouse models. Now, with EU support, researchers are developing good manufacturing practices (GMP) to support rigorous testing and gain regulatory approval. Success has the potential to change the outcomes for patients with the poorest prognoses.
Field of science
- /medical and health sciences/clinical medicine/cancer/colorectal cancer
- /natural sciences/biological sciences/cell biology
- /medical and health sciences/clinical medicine/cancer/pancreatic cancer
- /medical and health sciences/basic medicine/immunology/immunotherapy
Programme(s)
Call for proposal
H2020-SMEInst-2018-2020-2
See other projects for this call
Funding Scheme
SME-2 - SME instrument phase 2Coordinator
8952 Schlieren
Switzerland
