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Early Stage Researchers EDUCational Program on Factor VIII Immunogenicity

Objective

The development of anti-drug antibodies is the major complication of treatment with biotherapeutics. This is particularly true
of patients with haemophilia A (HA) who develop neutralizing antibodies to therapeutic factor VIII (FVIII) following
replacement therapy with exogenous pro-coagulant FVIII. The onset of neutralizing antibodies to FVIII, referred to as FVIII
inhibitors, represents a major societal concern owing to the enormous cost associated to the clinical management of
inhibitor-positive patients, that exceeds 200,000€/patient/year. The EDUC8 program is a multidisciplinary training program
with exposure of the enrolled ESRs to a core common educational package and development of individual PhD research
projects dedicated to decreasing the societal burden associated with the development of anti-FVIII antibodies in Europe. The
core educational program includes exposure to basic science in the fields of immunology and hemostasis, to the most
advanced “omic” technologies in order to anticipate tomorrow’s scientific discoveries, and to the importance of ethical
considerations and public awareness in today’s research. A key component of the training program is provided by immersion
of the ESRs in a clinical center for HA, which will provide them with a unique experience and foster the conception of novel
and realistic therapeutic approaches. The ESRs will exploit the accumulated theoretic and practical experience in an
entrepreneurship training on key strategic, technical, financial and human resource issues required for the creation of startups.
In a tribute to the concept of the fully developed mind coined by the French philosopher Michel de Montaigne on
education, our ambition is to form a novel generation of scientists with deep scientific knowledge, multicultural exposure,
imagination, pragmatism and understanding of both the academic and private sectors. This will foster translational research in European on the immunogenicity of therapeutic proteins.

Fields of science (EuroSciVoc)

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Keywords

Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)

Programme(s)

Multi-annual funding programmes that define the EU’s priorities for research and innovation.

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) H2020-MSCA-ITN-2019

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Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 274 802,04
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 274 802,04

Participants (6)

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